A5102995530- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Multiple Myeloma Research and Treatments
- Lung Cancer Treatments and Mutations
- Viral-associated cancers and disorders
- Colorectal Cancer Treatments and Studies
- Apelin-related biomedical research
- Inflammatory Biomarkers in Disease Prognosis
- Infrared Thermography in Medicine
- Immune Cell Function and Interaction
- Hematological disorders and diagnostics
- Parvovirus B19 Infection Studies
- Chemical Reactions and Isotopes
- Mosquito-borne diseases and control
- Cancer Research and Treatments
- Acute Myeloid Leukemia Research
- Sarcoma Diagnosis and Treatment
- Human Health and Disease
- Healthcare Systems and Public Health
- Advanced Scientific Research Methods
- Silymarin and Mushroom Poisoning
- Cardiovascular Disease and Adiposity
- Clinical Laboratory Practices and Quality Control
- Chemotherapy-induced organ toxicity mitigation
Ministry of Health of the Russian Federation
2020-2024
Rostov Research Institute of Oncology
2014-2022
Perm State Medical Academy
2020
Institute of Oil and Gas Problems of the Siberian Branch of the RAS
2006
Russian Academy of Sciences
2006
Institute of Plant and Animal Ecology
1996
Purpose : to study the level of LAG-3 expression on B-lymphocytes and feasibility using it as a marker for predicting response therapy in patients with chronic lymphocytic leukemia (CLL). Material Methods . The included 40 newly diagnosed CLL. All were divided into two groups: group I: Binet stage A, who did not receive II: C, received immunochemotherapy RB FCR regimes. According treatment regimen hematological therapy, 4 subgroups distinguished: IIA-RB, IIA-FCR, IIB-RB, IIB-FCR. control...
The prospects of using the selective plasma exchange in treatment first identified multiple myeloma (secretory) is substantiated (MM). Twenty-four patients (16 men and 8 women) were examined with stage II−III disease. Patients divided into two groups: main group (n = 13) inclusion therapy included a control 11) — treated according to standard protocol. received specific VCD scheme. concentrations paraprotein, free light chains Ig (FLC), glomerular filtration rate (GFR), blood toxicity...
Despite the long history of study, laboratory diagnosis gonococcal infection remains a complex task that does not have clearly regulated effective solution. Aim investigation was to assess species diversity microbiota genital tract men and women with suspected acute (AGGI) using test systems Russian manufacturers. A study samples contents urethra 69 posterior vaginal fornix fluids 33 reproductive age characteristic clinical manifestations presumptive AGGI made. Cultivation carried out...
Aim. To study the glomerular filtration rate (GFR) dynamics calculated by creatinine and cystatin C during induction immunochemotherapy in patients with newly diagnosed diffuse large B-cell lymphoma order to objectify method for estimation. Materials methods. The open longitudinal included 39 who received specialized treatment at Oncohematology Department of National Medical Research Centre Oncology (Rostov-on-Don) 2021. Patients according R-CHOP regimen (rituximab, doxorubicin,...
Background. Recently, studies have been conducted all over the world to study role of immune checkpoints in pathogenesis chronic lymphocytic leukemia (CLL) and possibility their use as prognostic markers. Of greatest interest are PD-1 (programmed cell death-1) LAG-3 protein (lymphocyte-activation gene 3). Aim. To features (CD279) (CD223) expression on blood B-cells CLL patients early markers for predicting hematological response therapy. Materials methods. The 30 with stage C according Binet...
With a frequency of 2.2 cases per 100,000 population in Russia, Hodgkin's lymphoma (HL) is one the most common malignant neoplasms young people. In connection with predominant spread HL among people, issue effective treatment various forms remains relevant. Currently, 70-90 % patients who have received standard chemotherapy or chemoradiotherapy long period remission. However, 10 progressive course, can`t achieve response, and 30 subsequently recur. The approach treating recurrent and/or...
This study included 45 children at the age from 5 to 17 years with type I diabetes mellitus complicated by diabetic retinopathy. All patients showed retinal thickening macula and reduced amplitude of local electroretinogram suggesting compromised capillary circulation. The blood flow was corrected transcranial magnetotherapy use an AMO-ATOS Ogolovie unit. results treatment were evaluated characteristics laser Doppler flometry. A course comprising 10 daily seances resulted in a significant...
e20027 Background: Our aim was a comparative analysis of the intensity lipid peroxidation, activity antioxidant enzymes, functional state albumin, and indices endogenous intoxication in blood patients with multiple myeloma (MM) during multi-course chemotherapy. Methods: Plasma content malondialdehyde (MDA), superoxide dismutase (SOD) catalase erythrocytes, total effective concentrations albumin (TCA ECA), level medium mass molecules (MMM), toxicity index (TI = TCA / ECA – 1) factor (IF...
e14018 Background: Apoptosis is important process in the tumor cell death and poorly studied L pts. Methods: An analysis ofapoptosis was made with an annexin test vitro bone marrow culture. The effect of pentoxyphyline low concentrations on cells 40 pts newly diagnosed relapses. Bone samples (2 ml) were placed into test-tubes heparinized medium treated diluted isotonic sodium chloride solution a concentration 10-6/ml. aspirate equivalent volume used as control. carried out dependence mts to...
Risk factors, p53, bcl-2, Topo2α, E-cadgerin, androgen receptor's expression, estrodiol, estron, testosterone, progesterone, prolactin, estrogen methabolitis, sex-steroid connecting globulin, growth factors: VEGF, EGF, TGFß1, IGF1, IGF2, plasmin, plasminogen, u-PA, t-PA, PAI-1 levels in the tumor and perifocal tissue, population subpopulation structure of lymphocytes peripheral blood, ploidy cell cycle estimating among 850 patients with different biologic breast cancer subtypes were tested....
e19580 Background: Many studies have been devoted to the molecular profile of diffuse large B-cell lymphoma; however, a clear and genetic picture primary mediastinal lymphoma (PMBLC) has not yet described. Studies reported various signaling pathways involved in PMBCL pathogenesis, with best known JAK-STAT NF-kB. This study was aimed at detection previously undescribed mutations, as well identification that may be interest search for new therapeutic targets PMBCL. Methods: Tumor biopsy...
e15009 Background: Multiple myeloma (MM) is a B-cell malignancy resulting from the abnormal proliferation of neoplastic plasma cells that produce monoclonal immunoglobulin (Ig). The high variability course this disease, its genetic clonal heterogeneity, due to chromosomal deletions, hyperploidy involving an odd number chromosomes, as well aberrations, such rearrangement Ig heavy chain gene loci. Since available biomarkers do not take into account feature MM, there need develop more advanced...
Introduction. Primary mediastinal large B-cell lymphoma is an aggressive variant of characterized by genetic heterogeneity. First-time therapy for primary usually includes immunochemotherapy. However, a substantial proportion patients do not respond to this therapy. Objective – analyze clinical characteristics refractory taking into account the results targeted next-generation sequencing (NGS). Materials and methods. A 22‑year-old patient with who had responded immunochemotherapy was tested...
ВОЗМОЖНОСТЬ ПРОГНОЗИРОВАНИЯ РАЗВИТИЯ РЕЦИДИВА ПРИ ДИФФУЗНОЙ В-КРУПНОКЛЕТОЧНОЙ ЛИМФОМЕ С ИСПОЛЬЗОВАНИЕМ ПОКАЗАТЕЛЕЙ ОБЩЕГО АНАЛИЗА КРОВИФранциянц Е.М. 1 , Бандовкина В.А. Куштова Л
e19530 Background: Herpesvirus infections are still a serious problem for patients with immunosuppression. The purpose of the study was to assess frequency occurrence herpes group viruses in Hematology Department Rostov Scientific Research Institute Oncology. Methods: DNA simplex virus type 1 and 2, cytomegalovirus (CMV), Epstein-Barr (EBV) 6 were extracted from samples whole peripheral blood MagNa Pure Compact apparatus manually on silica gel particles. amplification detection performed by...