A5082585847- Cervical Cancer and HPV Research
- Mycobacterium research and diagnosis
- Viral-associated cancers and disorders
- Cancer Diagnosis and Treatment
- Synthesis and Biological Evaluation
- Historical Gender and Feminism Studies
- S100 Proteins and Annexins
- Cardiovascular Disease and Adiposity
- Neutropenia and Cancer Infections
- Diphtheria, Corynebacterium, and Tetanus
- Cancer-related molecular mechanisms research
- Microbial Metabolism and Applications
- Epigenetics and DNA Methylation
- Polyomavirus and related diseases
- Inflammation biomarkers and pathways
- Oral microbiology and periodontitis research
- Animal Virus Infections Studies
- Syphilis Diagnosis and Treatment
- Synthetic Organic Chemistry Methods
- Synthesis and Catalytic Reactions
- Transplantation: Methods and Outcomes
- T-cell and Retrovirus Studies
- Virus-based gene therapy research
- Heart Rate Variability and Autonomic Control
- Antimicrobial Resistance in Staphylococcus
D. Mendeleyev University of Chemical Technology of Russia
2025
Rostov Research Institute of Oncology
2014-2019
Federal Almazov North-West Medical Research Centre
2008
Background. The personalized approach implies an individual choice of medicines and their doses for the patient, providing most effective safe pharmacotherapy. Objective: analysis frequencies UGT1A1 DPYD polymorphisms comparison genotyping data with irinotecan 5-fluorouracil-induced toxicity, respectively. Materials Methods . Venous blood 94 Caucasian patients (46 men 48 women, median age 61 years). *6 *28 alleles were identified by pyrosequencing, *2А allele was Real-time PCR. Results....
Objective: analysis of the type-specific prevalence high-risk HPV in dependence on gender, age, presence cancer. Material and methods: 424 patients RRIO were examined. Urogenital smears women men, urine men tested for DNA using PCR. Results: The relative share HPV-positive was 34.4% 39.9% men. percentage decreased older increased registered more oft en younger than 25 45 years old aged 26-45 years. Multiple-type infection young patients. 16 most prevalent women; next types 31, 52, 18 56 56,...
The purpose of the study was to assess infection tumor tissues with herpesviruses and human papillomavirus (HPV) in patients squamous cell carcinoma larynx (SCCL) reveal impact viral infections on effectiveness neoadjuvant therapy. DNAs HSV1,2, CMV, EBV HPV were studied by PCR 26 samples tissues. We revealed a high level herpesvirus SCCL (up 92.3 %), while less frequent – 19.2 %, including low-risk (LR HPV, 11.5 %) high-risk (HR 7.7 %). Significant differences detection rates pathogens found...
e18098 Background: The impact of viral infections tumor tissues on the effectiveness antitumor treatment in patients with laryngeal cancer is poorly studied. Methods: Tumor 26 histologically confirmed squamous cell carcinoma larynx (SCCL) were All received neoadjuvant chemotherapy (CT) prior to laryngectomy: 12 pts - cetuximab+cisplatin+5-fluorouracil, 14 same regimen without cetuximab. Fibrolaringoscopy was used assess CT results. DNAs herpes simplex virus type 1,2 (HSV1,2), cytomegalovirus...
The aim of the present study was to investigate evolution autonomic function during normal pregnancy without history hypertension. 23 women mean age 27,4±4,4 yrs on 12-14 weeks gestation were examined. Spontaneous baroreflex (BRS) analyzed by Finometer device with beat-to-beat blood pressure registration. All measurements performed at supine rest and 5 minute passive tilt (70). Baroreflex calculated sequence technique. 12 studies second time 26-30 week pregnancy. A or increases values...
e19530 Background: Herpesvirus infections are still a serious problem for patients with immunosuppression. The purpose of the study was to assess frequency occurrence herpes group viruses in Hematology Department Rostov Scientific Research Institute Oncology. Methods: DNA simplex virus type 1 and 2, cytomegalovirus (CMV), Epstein-Barr (EBV) 6 were extracted from samples whole peripheral blood MagNa Pure Compact apparatus manually on silica gel particles. amplification detection performed by...
e14017 Background: The purpose of the study was to analyze role EAA -test in diagnostics and evaluation effectiveness intensive treatment septic complications cancer patients. Methods: We examined 45 patients with postoperative period affected by development process. Clinical laboratory signs sepsis were identified all cases. severity condition measured on APACHE-II scale over 16, SAPS II - 20, SOFA 7, MODS 6 points. level activity endotoxin from 0,46 up 1.37. On 3-5th day start standard...
e15086 Background: Methicillin-resistant staphylococcus aureus (MRSA) is one of the most frequent multi-drug resistant pathogens nosocomial infections. Examination all coming patients for MRSA carriage state not obligatory in Russia, though it necessary part prevention programs. The purpose study was to assess level methicillin-resistant a cancer hospital. Methods: Nasal and throat washings, secretions from surgical wound drainage were used as material study. Presence content DNA fragments...
e17036 Background: The purpose of the study was to detect HPV in tumor tissue, perifocal area and healthy tissue patients with vulvar cancer. Methods: Tissue samples from tumor, 69 cancer aged 60-83 years were studied. DNAs high-risk low-risk determined by Real-Time PCR. Results: 11 found 8.6% patients, – 30.4%. 16 18 most frequent (28.5% each), 31 association 14.2%. High-risk 25% area: 50%, associations genotypes 25%. 21.05%: 25%, 53 Thus, 25.8% samples, including - 33.3%, 13.3% each, 52...
e17027 Background: The purpose of the study was to analyze detection rate and viral load HPV16 HPV18 in tissues cervical tumors lymph nodes depending on disease stage presence metastases. Methods: FPPE (histologically verified squamous cell carcinoma) regional 146 patients were studied; 68% under 50 years age. DNA extraction performed by sorbent method after tissue dewaxing. detected PCR FISH with calibrators. Results: Stage I observed 49% patients, II 29%, III 22%. Metastases found 30...
e15066 Background: Aberrant methylation of CpG sites within promoter regions cancer-related genes is an important epigenetic event in carcinogenesis. The frequency changes different sporadic colorectal cancer (CRC), according to various estimates, varies from 15 80% which allows the use this indicator for development new prognostic biomarkers CRC. Methods: Methylation was quantified at 47 CpG-sites four (MGMT, APC, CDH13 and MLH1) tumors normal tissue using bisulfite pyrosequencing. 25...
e17026 Background: The purpose of the study was to identify rate Bacteroides spp. infection in vulvar cancer tissues. Methods: FFPE samples tumor and peritumoral area healthy tissues 44 patients with cancer, as well frozen 34 cervical 29 uterine were studied. DNAs detected by real-time PCR. Results: 18.75% had stage I disease, 75.0% - II, 6.25% III. analysis histological type showed squamous cell carcinoma: G1 31.25%, G2 68.75%. B. fragilis found all tissues: tissue – 87.5%, perifocal 76.9%...
e15516 Background: The purpose of the study was to compare rates bacterial and fungal colonization mucosa in stomach cancer gastritis. Methods: 59 tumor healthy tissue samples 33 bioptates gastritis were studied. DNAs extracted by adsorption method. Enterobacteriaceae, Staphylococcus spp., Streptococcus Candida Bacteroides spp. determined real-time PCR. Results: 40.0% 30 patients with had adenocarcinoma, 13.3% – signet ring cell carcinoma, 6.7% undifferentiated cancer, NHL, 3.3% squamous...
e17001 Background: The purpose of the study was to determine rate various HPV genotypes detection in tissues tumors female reproductive organs. Methods: FFPE and frozen tissue samples cervical cancer (n=126), vulvar (n=113) uterine (n=29) were studied. DNAs 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58 59 determined by Real-Time PCR. Results: found 94.4% tissue, 65.5% - 28.3% tissue. 16 18 most frequent (78.8%). detected 60.9%, – 59.0% 54.5%. On contrary, more (40.9%) less (18.4%) (2.7%)....
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Objective. To study level and structure of microbial colonization in cancer patients before admission to a surgery department using molecular methods. Materials Methods. The presence DNA methicillin-resistant Staphylococcus aureus, methicillinresistant coagulase-negative staphylococci, Candida albicans/C. glabrata/C. krusei, Acinetobacter baumannii the clinical specimens antimicrobial resistance genes cultures were detected by multiplex real-time PCR. A total 741 samples 313 studied....