A5102899090- Multiple Myeloma Research and Treatments
- Viral-associated cancers and disorders
- Silymarin and Mushroom Poisoning
- Parvovirus B19 Infection Studies
- Lymphoma Diagnosis and Treatment
- Sepsis Diagnosis and Treatment
- Chemotherapy-induced cardiotoxicity and mitigation
- Histiocytic Disorders and Treatments
- Drug Transport and Resistance Mechanisms
- Glycosylation and Glycoproteins Research
- Dermatological and COVID-19 studies
- Antifungal resistance and susceptibility
- Medical and Biological Ozone Research
- Cell death mechanisms and regulation
- Fungal Infections and Studies
- Cytomegalovirus and herpesvirus research
- Bacterial Identification and Susceptibility Testing
- Electrolyte and hormonal disorders
- Multiple and Secondary Primary Cancers
Rostov Research Institute of Oncology
2014-2022
The prospects of using the selective plasma exchange in treatment first identified multiple myeloma (secretory) is substantiated (MM). Twenty-four patients (16 men and 8 women) were examined with stage II−III disease. Patients divided into two groups: main group (n = 13) inclusion therapy included a control 11) — treated according to standard protocol. received specific VCD scheme. concentrations paraprotein, free light chains Ig (FLC), glomerular filtration rate (GFR), blood toxicity...
e20027 Background: Our aim was a comparative analysis of the intensity lipid peroxidation, activity antioxidant enzymes, functional state albumin, and indices endogenous intoxication in blood patients with multiple myeloma (MM) during multi-course chemotherapy. Methods: Plasma content malondialdehyde (MDA), superoxide dismutase (SOD) catalase erythrocytes, total effective concentrations albumin (TCA ECA), level medium mass molecules (MMM), toxicity index (TI = TCA / ECA – 1) factor (IF...
e14018 Background: Apoptosis is important process in the tumor cell death and poorly studied L pts. Methods: An analysis ofapoptosis was made with an annexin test vitro bone marrow culture. The effect of pentoxyphyline low concentrations on cells 40 pts newly diagnosed relapses. Bone samples (2 ml) were placed into test-tubes heparinized medium treated diluted isotonic sodium chloride solution a concentration 10-6/ml. aspirate equivalent volume used as control. carried out dependence mts to...
e15009 Background: Multiple myeloma (MM) is a B-cell malignancy resulting from the abnormal proliferation of neoplastic plasma cells that produce monoclonal immunoglobulin (Ig). The high variability course this disease, its genetic clonal heterogeneity, due to chromosomal deletions, hyperploidy involving an odd number chromosomes, as well aberrations, such rearrangement Ig heavy chain gene loci. Since available biomarkers do not take into account feature MM, there need develop more advanced...
e19530 Background: Herpesvirus infections are still a serious problem for patients with immunosuppression. The purpose of the study was to assess frequency occurrence herpes group viruses in Hematology Department Rostov Scientific Research Institute Oncology. Methods: DNA simplex virus type 1 and 2, cytomegalovirus (CMV), Epstein-Barr (EBV) 6 were extracted from samples whole peripheral blood MagNa Pure Compact apparatus manually on silica gel particles. amplification detection performed by...
e19501 Background: Current protocols of therapy for multiple myeloma (MM) can lead to the complete elimination tumor cells, allowing ascertaining presence MRD-negative remission in patient. possibilities laboratory diagnostics allow assessment effectiveness according clinical, morphological and serological parameters, as well determination individual parameters antigen expression cells. The purpose study was analyze necessity some by immunophenotyping bone marrow patients with MM disease...
e14084 Background: The purpose of the study was to determine etiology invasive candidiasis (IC) and investigate in vitro activity caspofungin azoles for blood isolates Candida fungi. Methods: We performed a multidisciplinary prospective patients with clinical signs IC obtained intensive care units (ICU), oncohematology oncology departments hospitals Rostov-on-Don Rostov region 2012-2015. fungi were identified using MALDI-TOF MS; interpretation according CLSI 2012, M27-S4 criteria....
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e19022 Background: The purpose of the study was to reveal prevalence B19V in adult patients with lymphomas and influence on results chemotherapy (CT). Methods: included 41 aged 48.9±2.3 years: 12 Hodgkin’s lymphoma (HL), 29 Non-Hodgkin’s (NHL) (21 aggressive, 8 indolent). Patients received CT according tumor immunophenotype. DNA determined plasma bone marrow (BM) by qPCR, IgМ IgG serum ELISA. Results: 78.0% had IgG, mean concentration 158.1±12.9 U/mL. detected 7.3%, BM 48.8%. Viral load...
e19554 Background: The purpose of this study was to assess NT-proBNP as a marker renal dysfunction in patients with diffuse large B-cell lymphoma receiving immune polychemotherapy. Methods: involved 24 aged 23-69 years (median 57 years) primary diagnosis (DLBCL). status assessed by the blood serum levels creatinine, urea, (Vitros 5600, USA), sodium (Cobas b221, Switzerland) calculation glomerular filtration rate (GFR) according CKD-EPI formula, well urine albumin Integra 400 plus,...