A5046052575- Cancer Cells and Metastasis
- Cancer Research and Treatments
- 3D Printing in Biomedical Research
- Material Properties and Applications
- Berberine and alkaloids research
- Cancer Genomics and Diagnostics
- Material Properties and Failure Mechanisms
- Cancer Treatment and Pharmacology
- Animal Nutrition and Health
- Cancer, Lipids, and Metabolism
- Food Industry and Aquatic Biology
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Chemical Reactions and Isotopes
- Human Health and Disease
- Engineering Diagnostics and Reliability
- Indigenous Studies and Ecology
- Advanced materials and composites
- Plant-based Medicinal Research
- Porphyrin and Phthalocyanine Chemistry
- Multiple Myeloma Research and Treatments
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Machine Learning in Bioinformatics
- Virus-based gene therapy research
Rostov Research Institute of Oncology
2020-2023
Southern Federal University
2017-2022
Ministry of Health of the Russian Federation
2020-2021
Government of Russia
2020
Ministry of Emergency Situations
2016
Chelyabinsk Regional Clinical Oncology Center
2012
Ivanovo State Agricultural Academy named after D.K. Belyaev
1995
Importance: Cutaneous melanoma is regarded as the most lethal form of skin cancer. According to literature, issues associated with accurate prognosis and early detection relapses hinder effective treatment melanomas. Over past 20 years, microRNAs have been shown modulate various biological processes. Disruption microRNA expression activity can contribute risk cancer development, including cutaneous melanoma. Therefore, we decided study some biomarkers for future use in diagnosis. Objective:...
Malignant neoplasms remain one of the leading causes mortality worldwide, underscoring need for development novel and effective therapeutic strategies their treatment. In recent years, scientific community has actively pursued search pharmaceutical preparations with minimal adverse effects high efficacy, capable achieving complete remission in patients. this context, berberine, a natural phytochemical compound derived from various species Berberis, garnered increasing attention due to its...
Abstract Lung cancer is referred to as the second most common worldwide and mainly associated with complex diagnostics absence of personalized therapy. Metabolomics may provide significant insights into improvement lung through identification specific biomarkers or biomarker panels that characterize pathological state patient. We performed targeted metabolomic profiling plasma samples from individuals non-small cell (NSLC, n = 100) without any chronic pathologies (n identify relationship...
Summary We have characterized the HLA‐A, ‐B, ‐DRB1, ‐DQA1 and ‐DQB1 profiles of three major ethnic groups living in Chelyabinsk Region Russian South Urals, viz., Russians ( n = 207), Bashkirs 146) Tatars 135). First field level typing was performed by PCR using sequence‐specific primers. Estimates included carriage gene frequencies, linkage disequilibrium its significance related values. Population comparisons were made between allele family frequencies populations these 20 others a...
The Biobank of the National Medical Research Center Oncology is a multi-layered infrastructure with large collections biological samples, complemented by extensive and well-annotated clinical pathological patient data, including medical images, histology, molecular analysis biosamples. To date, biobank contains primary immortalized cancer cell lines human origin. collection was formed from samples postoperative material taken during removal tumors various localizations (breast cancer,...
Aim. To create a collection of samples blood components patients with multiple myeloma for potential fundamental and applied biomedical research. Material methods . The material was collected according to the developed algorithm, including clinical information, biological material, sample preparation, quality control storage in biobank National Medical Research Center Oncology. Results. As August 2021, cryostorage Oncology contains 175 serum, plasma mononuclear cell fraction myeloma. Samples...
3D печать - это новый многообещающий метод создания трехмерных клеточных конструкций для всевозможных биомедицинских исследований. К преимуществам использования 3D-биопечати в биомедицинской сфере относятся разработка персонализированного дизайна каждого пациента, высокая точность и создание сложных структур. Основным компонентом являются биочернила, обеспечивающие биосовместимость, механическую стабильность, высокое разрешение вовремя после печати.
 Цель. Изучить влияние способа...
Abstract Lung cancer is referred to as the second most common worldwide and mainly associated with poor diagnostics absence of personalized therapy. Metabolomics may provide significant insights into improvement lung treatment through identification specific biomarkers or biomarker panels that characterize pathological state patient. We performed targeted metabolomic profiling plasma samples from individuals non-small cell (NSLC, n = 100) without any chronic pathologies (n identify...
Purpose of the study. Testing protocol obtaining cell spheroids breast cancer cultures for bioprinting by growing in alginate drops. Materials and methods. Cells lines BT-20 MDA-MB-453 were cultured DMEM medium supplemented with 10 % FBS. Next, cells removed from plastic using a trypsin-V ersene solution resuspended sterile 2 DPBS to concentration 5 cells/ml. Then was slowly dripped through 30G needle into cooled calcium chloride (100 mM) height cm. After polymerization, drops washed two...
Background. Alkylresorcinols (ARs) are polyphenolic compounds of microbial origin with a wide spectrum biological activities and potentially involved in host immune functioning. The present study is aimed at evaluating alterations AR content blood serum faeces from healthy donors patients lung cancer connection response to checkpoint inhibitor (ICI) therapy estimate the regulatory potential AR. Methods. Quantitative analysis levels, as well other metabolites faeces, was performed using gas...
Цель исследования: оценить уровень кисспептина у девочек с нарушением менструальной функции учетом массы тела и эффективность аппаратных методов коррекции клинико-гормональных изменений
e15045 Background: Berberine is an alkaloid compound with a structure that highly similar to of intercalating agents. It affects numerous cell signaling pathways and widely studied as potential anticancer drug. known berberine cancer cells migration through metalloproteinase-2 inhibition, but this effect was never on glioma cells. Anti-migratory drugs are special interest in brain therapy since glioma's invasive nature makes total surgical removal tumor practically impossible. The aim the...
Glioblastoma remains the most common and aggressive primary brain tumor today. Because of neuroanatomical location glioblastoma, conventional chemotherapy radiation therapy have limited efficacy in patients with these tumors. Over past decade, antitumor immunotherapy has become widespread among modern therapeutic approaches. The importance immunotherapeutic methods lies their ability to increase effectiveness cancer treatment prevent relapses by enhancing systemic local immune response...
Purpose of the study. Evaluation cytotoxic effect strains RVK100 and RVK228 a new unclassified group human rotaviruses on peripheral blood mononuclear cells in vitro. Materials methods. As material for study, we used healthy donor. The were exposed to two 24 48 hours. cytotoxicity tested viruses was assessed using Colorimetric Cell Viability Kit I (WST-8) (PromoCell, Germany). Analysis lymphocytes subpopulation composition FACSCantoII flow cytometer (BD, USA) monoclonal antibodies antigens:...
e15077 Background: Plant metabolites are traditionally a valuable source of anticancer drugs. The huge variety molecular structures found in plants makes it possible to isolate substances that possess not only antimitotic, but also anti-migratory properties on cancer cells. objective this study was evaluate the activity selected from Petasítes sp. plants. Methods: Cells cell cultures PC3 (prostate cancer), A431 (skin CaCo-2 (colorectal HeLa (cervical cancer) and T98G (glioma) were seeded an...
e15079 Background: Initially, berberine was used as an antimicrobial agent in traditional medicine, but its anticancer properties were later discovered. In addition to cytotoxic effect, also has the ability inhibit cell motility, which been demonstrated some permanent cancer lines. The objective of this study assess anti-migratory activity cultures compared primary are generally thought better reflect tumor characteristics. Methods: H1299 lung cancer, PC3 prostate and T98G glioma cells, well...
e15009 Background: Multiple myeloma (MM) is a B-cell malignancy resulting from the abnormal proliferation of neoplastic plasma cells that produce monoclonal immunoglobulin (Ig). The high variability course this disease, its genetic clonal heterogeneity, due to chromosomal deletions, hyperploidy involving an odd number chromosomes, as well aberrations, such rearrangement Ig heavy chain gene loci. Since available biomarkers do not take into account feature MM, there need develop more advanced...