Anton А. Keskinov
A5047300855- Immunotherapy and Immune Responses
- Healthcare Systems and Public Health
- Cancer Immunotherapy and Biomarkers
- Human Health and Disease
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- CAR-T cell therapy research
- Radiation Therapy and Dosimetry
- Cancer, Stress, Anesthesia, and Immune Response
- RNA modifications and cancer
- vaccines and immunoinformatics approaches
- T-cell and B-cell Immunology
- Nutrition and Health in Aging
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Probiotics and Fermented Foods
- Frailty in Older Adults
- Nanoparticle-Based Drug Delivery
- Genetic Associations and Epidemiology
- Vagus Nerve Stimulation Research
- Diet and metabolism studies
Federal Medical-Biological Agency
2022-2025
Center for Strategic Research
2023-2025
St. Petersburg Research Institute of Radiation Hygiene
2020
University of Pittsburgh Medical Center
2014-2019
Ministry of Health of the Russian Federation
2017-2019
Russian Cancer Research Center NN Blokhin
2017
University of Pittsburgh
2013-2016
Pittsburg State University
2016
UPMC Hillman Cancer Center
2014
Abstract The tumor microenvironment has been compared with a nonhealing wound involving complex interaction between multiple cell types. Schwann cells, the key regulators of peripheral nerve repair, have recently shown to directly affect nonneural healing. Their role in cancer progression, however, largely limited neuropathic pain and perineural invasion. In this study, we showed that melanoma activated otherwise dormant functions cells aimed at regeneration Such reprogramming into...
Aim. To study the epidemiological characteristics and changes of hypertension (HTN), as well factors associated with HTN in Russian population aged 35-74 years. Material methods. The Epidemiology Cardiovascular Diseases their Risk Factors Regions Federation-3 (ESSE-RF3) examined a representative sample years 15 regions response >70% (n=28611). Modular design questionnaire was used. Blood pressure (BP) measured twice after 5-minute rest sitting position on right arm an Omron blood monitor....
The gut microbiota plays an important role in maintaining human health, as well the development of various pathologies, indicated by a large amount research. One manifestations imbalance microbiome composition is appearance diseases or immune reactions, particular, atopic dermatitis (AD) and/or food allergies (FA). In this research, using 16S NGS sequencing, it was found that children with and can be characterized having higher inflammatory potential. Both groups exhibited abundance...
Protumorigenic activity of immune regulatory cells has been proven to play a major role in precluding immunosurveillance and limiting the efficacy anticancer therapies. Although several approaches have offered deplete myeloid‐derived suppressor (MDSC) T cells, there are no data on how control suppressive dendritic cell (DC) accumulation or function tumor environment. immunosuppressive DC cancer was implicated immature plasmacytoid DC, details conventional (cDC) develop properties remain less...
Medicine of the 21st century has an extensive arsenal means for diagnosing diseases. High-tech equipment is able to detect pathologies without clinical manifestations during latent stage disease development. Actigraphy portable device based on accelerometer, used tracking sleep parameters, and also, well established as a tool circadian rhythms person. not alternative use polysomnography, however, it advantages in ease use, cost, size device, addition allowing long-term continuous recording...
It is known that the gut microbiota plays an important role in many biological processes of human body. However, all factors and mechanisms influencing changes composition microbiome are not fully understood. As results previous studies show, long-term food preferences play a significant modulating intestinal microbiota. At same time, reflecting peculiarities relationship vitamins, trace elements adequately characterized. Vitamins have bidirectional effect on On one hand, they influence...
Introduction Minimally invasive diagnostics based on liquid biopsy makes it possible early detection of lung cancer (LC). The blood plasma circulating cell-free DNA (cfDNA) fragments reflect the genome and chromatin status are considered as integral biomarkers biological entities for ‘cancer-of-origin’ prediction. aim this work is to create a method processing next-generation sequencing (NGS) data an interpretable binary classification model (CM), which analyzed cfDNA fragmentation features...
Aim. To analyze the association of neighborhood infrastructure with cardiovascular diseases (CVDs) and their risk factors (RFs) in a representative all-Russian adult population sample. Material methods . Data from ESSE-RF3 study conducted 2020-2022 15 Russia regions were used. The total sample included 28731 men women aged 35-74 years. was assessed using Russian version (Neighborhood Environmental Walkability Scale (NEWS). following CVDs assessed: hypertension, obesity, hypercholesterolemia,...
We present a clinical case of familial LMNA-associated cardiomyopathy, confirmed by whole genome sequencing. The typical for lamin-associated cardiomyopathy indicates pathogenic nature the mutation in first exon LMNA gene, previously considered unknown significance. presented demonstrates radical change patient treatment strategies context widespread introduction molecular genetic research methods into practice.
BACKGROUND . More than one hundred candidate genes have been associated with longevity, including APOE, FOXO1A, GF1, IGF1, INCR, TP53, etc. Despite extensive research, the precise molecular and genetic underpinnings remain elusive due to low reproducibility of findings. Moreover, most studies focused on exomes neglected intergenic regulatory regions DNA. AIM To examine basis longevity create a prognostic model that assesses chance reaching age 90. MATERIALS AND METHODS study predictors...
BACKGROUND . A trend toward demographic aging of the population is currently observed in most countries worldwide. More and more people are achieving longevity, both due to environmental factors lifestyle, as well molecular genetic processes. Few large-scale studies have examined all contributing longevity Russia globally. Fewer them used a multi-omics approach, which could provide better insight into phenomenon by integrating genomic, epigenomic, transcriptomic metagenomic data. AIM. To...
This research aimed to evaluate the potency of preparation based on heparinized iron oxide nanoparticles (hIONPs) in combination with radiation therapy, including magnetic delivery via applied field (AMF), sarcoma and cervical cancer models. For vitro studies, cells rhabdomyosarcoma (RD), fibrosarcoma (HT1080), (HeLa S3) were treated hIONPs analyzed for survival rate hIONP uptake. Then, cell morphology, cycle, increase reactive oxygen species, mitochondria depolarization, ability form...
Aim. To study the prevalence of non-alcoholic fatty liver disease (NAFLD) and its association with cardiovascular risk factors (RFs). Material methods. The database from ESSE-RF2 ESSE-RF3 epidemiological studies was used, including data surveys population aged 35-64 years in 18 Russian regions (n=21204). assess NAFLD, index (FLI) used. Statistical analysis performed using statistical programming language R environment (version 3.6.1) open-source code. significance level for all tested...
Nerve endings are often identified within solid tumors, but their impact on the tumor growth and progression remains poorly understood. Emerging data suggests that central nervous system may affect cancer development spreading via hypothalamic-pituitary-adrenal axis autonomous system. However, role of afferent sensory neurons in is unclear, except some reports perineural invasion prostate pancreatic cancer-related pain syndrome. Here, we provide results primary testing concept interaction...
Non-alcoholic fatty liver disease (NAFLD) is considered the most common chronic worldwide, affecting nearly 25% of global adult population. Increasing evidence suggests that functional and compositional changes in gut microbiota may contribute to development promote progression NAFLD. 16S rRNA gene next-generation sequencing widely used determine specific features NAFLD microbiome, but a complex system such as requires comprehensive approach. We three different approaches: MALDI-TOF-MS...
Aim. To study the prevalence of dyslipidemias and their association with various risk factors in Russian population men women aged 35-74 years 2020-2022. Material methods. This work was carried out as part Epidemiology Cardiovascular Diseases Risk Factors Regions Federation-3 (ESSE-RF3) study. The sample included 28731 living 15 regions. Hypercholesterolemia (HC) diagnosed total cholesterol (TC) ≥5,0 mmol/l, while elevated low-density lipoprotein (LDL-C) considered ≥3,0 hypertriglyceridemia...
Aim. To analyze the prevalence of smoking according to Epidemiology Cardiovascular Diseases and their Risk Factors in Regions Russian Federation-3 (ESSE-RF3) study, compare these data with previous two stages. Material methods. Data from following three cross sections ESSE-RF study were used: 2013-2014, 2017, 2020-2022. At first stage, probability was assessed ESSE-RF3 2020-2022 (n=28628, 35-74 years). second an analysis carried out over time using all (n=43804, 35-64 Results. In overall...