A5101960702- Healthcare Systems and Public Health
- Nutrition and Health in Aging
- Body Composition Measurement Techniques
- Growth Hormone and Insulin-like Growth Factors
- Allergic Rhinitis and Sensitization
- Spaceflight effects on biology
- Nutrition, Genetics, and Disease
- Data-Driven Disease Surveillance
- Cardiovascular and exercise physiology
- Gut microbiota and health
- Neurogenetic and Muscular Disorders Research
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Genetics and Physical Performance
- Frailty in Older Adults
- Human Health and Disease
- Diet and metabolism studies
- Nuclear Structure and Function
- Technology and Human Factors in Education and Health
Federal Medical-Biological Agency
2017-2025
Center for Strategic Research
2025
North-Western State Medical University named after I.I. Mechnikov
2015-2016
We present a clinical case of familial LMNA-associated cardiomyopathy, confirmed by whole genome sequencing. The typical for lamin-associated cardiomyopathy indicates pathogenic nature the mutation in first exon LMNA gene, previously considered unknown significance. presented demonstrates radical change patient treatment strategies context widespread introduction molecular genetic research methods into practice.
BACKGROUND . More than one hundred candidate genes have been associated with longevity, including APOE, FOXO1A, GF1, IGF1, INCR, TP53, etc. Despite extensive research, the precise molecular and genetic underpinnings remain elusive due to low reproducibility of findings. Moreover, most studies focused on exomes neglected intergenic regulatory regions DNA. AIM To examine basis longevity create a prognostic model that assesses chance reaching age 90. MATERIALS AND METHODS study predictors...
BACKGROUND . A trend toward demographic aging of the population is currently observed in most countries worldwide. More and more people are achieving longevity, both due to environmental factors lifestyle, as well molecular genetic processes. Few large-scale studies have examined all contributing longevity Russia globally. Fewer them used a multi-omics approach, which could provide better insight into phenomenon by integrating genomic, epigenomic, transcriptomic metagenomic data. AIM. To...
Introduction: Morphofunctional changes of the circulatory system organs detected in athletes may remain without due attention, as clinical (phenotypic) signs pathological abnormalities are very similar to manifestations cardiovascular adaptation intensive physical loads. The aim study is propose a personalized algorithm for biomedical support professional with and diseases based on genomic data. Materials methods: results in-depth medical examination (2021-2023) 15,464 who members Russian...
Background: In recent years, an increase in the number of long-living adults has been a dominant demographic trend Russia. This population group is highly susceptible to cognitive dysfunctions. Cognitive impairment disrupts lives those affected and puts immense burden on their caregivers. Currently, there are no clinically applicable therapies or prevention strategies for impairment. Therefore, it critically important determine which lifestyle factors contribute decline develop well-informed...
RELEVANCE: Sarcopenia is one of the leading geriatric syndromes that increases risk disability, falls and injuries. This syndrome particular importance for centenarians aged 90 years older, whom a detailed analysis course sarcopenia has not previously been carried out hormonal metabolic characteristics this condition have described. AIM OF THE STUDY: To analyze features status in nonagenarians with to identify factors increase developing MATERIALS AND METHODS: The study included 2221 people...
BACKGROUND. The role of insulin-like growth factor-1 (IGF-1) and its levels in aging have been established clinical experimental studies. Aging-associated geriatric syndromes underlie functional adaptive decline older patients. However, there is insufficient evidence that aging-associated decrease circulating IGF-1 associated with syndromes, particularly long-living adults. This study aimed to examine the associations between METHODS. cross-sectional included nonagenarians recruited...
Abstract COVID-19 is caused by an airborne virus, SARS-CoV-2. The upper respiratory tract (URT) is, therefore, the first system to endure attack. Inhabited assemblage of microbial communities, a healthy URT wards off invasion. However, once invaded, it becomes destabilised, which could be crucial establishment and progression infection. We examined 696 samples collected from 285 patients at three time-points throughout their hospital stay 100 controls. used 16S ribosomal RNA sequencing...