A5086269732- Optical and Acousto-Optic Technologies
- Genomics and Rare Diseases
- Folate and B Vitamins Research
- Genetic Associations and Epidemiology
- Gut microbiota and health
- Photonic and Optical Devices
- Photorefractive and Nonlinear Optics
- Genomic variations and chromosomal abnormalities
- Image Processing Techniques and Applications
- Healthcare Systems and Public Health
- Plant tissue culture and regeneration
- Cardiac pacing and defibrillation studies
- Dementia and Cognitive Impairment Research
- Cardiovascular Effects of Exercise
- Child and Adolescent Psychosocial and Emotional Development
- Liver Disease Diagnosis and Treatment
- Advanced Vision and Imaging
- Photosynthetic Processes and Mechanisms
- Bipolar Disorder and Treatment
- Allergic Rhinitis and Sensitization
- Cardiomyopathy and Myosin Studies
- Alzheimer's disease research and treatments
- Optical measurement and interference techniques
- Cardiac Health and Mental Health
- Frailty in Older Adults
Federal Medical-Biological Agency
2017-2025
Ufa Institute of Chemistry
2024
ETH Zurich
2023
St Petersburg University
2020
Institute of Engineering Physics
2000
Moscow Engineering Physics Institute
2000
This paper introduces a novel agent-based approach for enhancing existing portfolio strategies using Proximal Policy Optimization (PPO). Rather than focusing solely on traditional construction, our aims to improve an already high-performing strategy through dynamic rebalancing driven by PPO and Oracle agents. Our target is enhance the 60/40 benchmark (60% stocks, 40% bonds) employing Regret-based Sharpe reward function. To address impact of transaction fee frictions prevent signal loss, we...
BACKGROUND . More than one hundred candidate genes have been associated with longevity, including APOE, FOXO1A, GF1, IGF1, INCR, TP53, etc. Despite extensive research, the precise molecular and genetic underpinnings remain elusive due to low reproducibility of findings. Moreover, most studies focused on exomes neglected intergenic regulatory regions DNA. AIM To examine basis longevity create a prognostic model that assesses chance reaching age 90. MATERIALS AND METHODS study predictors...
BACKGROUND . A trend toward demographic aging of the population is currently observed in most countries worldwide. More and more people are achieving longevity, both due to environmental factors lifestyle, as well molecular genetic processes. Few large-scale studies have examined all contributing longevity Russia globally. Fewer them used a multi-omics approach, which could provide better insight into phenomenon by integrating genomic, epigenomic, transcriptomic metagenomic data. AIM. To...
Aging puts the human body under an immense stress and makes it extremely susceptible to many diseases, often leading poor outcomes even death. Long-living individuals represent a unique group of people who withstood time offer abundance information on body's ability endure pressure aging. In this study, we sought identify predictors overall one-year mortality in 1641 long-living individuals. Additionally, analyzed risk factors for COVID-19-related morality, since statistics demonstrated...
Background Psycho-emotional well-being is essential for living a life of satisfaction and fulfillment. However, depression anxiety have become the leading mental health issues worldwide, according to World Health Organization. Both disorders been linked stress other psychological factors. Their genetic basis remains understudied. Methods In 2020–2021, psycho-emotional 30,063 Russians with no known psychiatric history was assessed using Hospital Anxiety Depression Scale (HADS) general HADS...
Previous studies examining the molecular and genetic basis of cognitive impairment, particularly in cohorts long-living adults, have mainly focused on associations at genome or transcriptome level. Dozens significant dementia-associated genes been identified, including APOE, APOC1, TOMM40. However, most these did not consider intergenic interactions functional gene modules involved function, nor they assess metabolic changes individual brain regions. By combining analysis with a...
BACKGROUND: Identification of target genes responsible for visible phenotypic effect may contribute to the development transgene-free bioengineering strategies and application crop varieties with edited genome. CAPRICE (CPC) is a single-repeat R3 MYB transcription factor, involved in anthocyanin biosynthesis trichome formation. It assumed that CPC controls expression Dihydroflavonol-4-reductase (DFR), key gene biosynthesis. AIM: The aim study was determine whether knockout using CRISPR/Cas9...
Introduction: Morphofunctional changes of the circulatory system organs detected in athletes may remain without due attention, as clinical (phenotypic) signs pathological abnormalities are very similar to manifestations cardiovascular adaptation intensive physical loads. The aim study is propose a personalized algorithm for biomedical support professional with and diseases based on genomic data. Materials methods: results in-depth medical examination (2021-2023) 15,464 who members Russian...
Background Cognitive impairment is an irreversible, aging-associated condition that robs people of their independence. The purpose this study was to investigate possible causes and propose preventive options. Methods We assessed cognitive status in long-living adults aged 90+ ( n = 2,559) performed a genome wide association using two sets variables: Mini-Mental State Examination scores as continuous variable (linear regression) binary (> 24, no impairment; <10, impairment)...
In this paper we introduce the Tangent Sampson error, which is a generalization of classical error in two-view geometry that allows for arbitrary central camera models. It only requires local gradients distortion map at original correspondences (allowing pre-computation) resulting negligible increase computational cost when used RANSAC or refinement. The effectively approximates true-reprojection large variety cameras, including extremely wide field-of-view lenses cannot be undistorted to...
Population studies are essential for gathering critical disease prevalence data. Automated pathogenicity assessment tools enhance the capacity to interpret and annotate large amounts of genetic In this study, we assessed cancer-associated germline variants in Russia using a semiautomated variant interpretation algorithm.
Sparse autoencoders (SAEs) have become a core ingredient in the reverse engineering of large-language models (LLMs). For LLMs, they been shown to decompose intermediate representations that often are not interpretable directly into sparse sums features, facilitating better control and subsequent analysis. However, similar analyses approaches lacking for text-to-image models. We investigated possibility using SAEs learn features few-step diffusion models, such as SDXL Turbo. To this end, we...
Dilated cardiomyopathy (DCM) is a leading cause of heart failure, sudden cardiac death, and transplantation in young patients. The causes DCM are varied include genetic factors metabolic, infectious, toxic others factors. Today it known that germline mutations more than 98 genes can be associated with the occurrence DCM. However, penetrance these often depends on combination factors, including modifiable ones, i.e. those change under influence environment. About 20-25% genetically determined...
This paper is devoted to the numericalinformation flows and adaptive decompositions of thegeneral Haar functions connected with them. The aim ofthis propose an wavelet decompositionusing compression algorithm for a flow ofnumerical information length M complexity𝑶(𝑴) given precision 𝜀> 0. numericalflows are associated irregular spline grids. paperdiscusses calibration relations, embedding spaces their decompositions.The structure decomposition/ reconstructionalgorithms done. cases finite...
Since the moment of laser appearance and till now attention concentrated on great potentiality realization coherent optical data processing systems. However, difficulties occurred in creating workable systems this type were reasons spreading field investigation diffraction which not only coherent, but partially non-coherent illumination is used. Spatial coherence light spectrum components as well amplitude, phase polarization passed through system can be modulated by information to...
Abstract COVID-19 is caused by an airborne virus, SARS-CoV-2. The upper respiratory tract (URT) is, therefore, the first system to endure attack. Inhabited assemblage of microbial communities, a healthy URT wards off invasion. However, once invaded, it becomes destabilised, which could be crucial establishment and progression infection. We examined 696 samples collected from 285 patients at three time-points throughout their hospital stay 100 controls. used 16S ribosomal RNA sequencing...
The scheme of the incoherent holographic correlator with two-coordinate acoustooptic deflector (AOD) for input recognized images is presented. Because AOD forms an image as a sequence dynamic diffraction gratings, it allows to put filter directly behind AOD. So, using this circumstance, conventional was significantly reduced. experimental setup memory and monochromatic illumination described. Experimental results on recognition test objects semiconductor laser source are correlation signals...
The compact scheme of the incoherent holographic correlator with two-coordinate acoustooptic deflector (AOD) for input recognized images is presented. Because AOD forms an image as a sequence dynamic diffraction gratings, it allows to put filter directly in place where situated. experimental setups memory and monochromatic illumination are described. Experimental results on recognition test objects two different sources correlation signals He-Ne laser semiconductor coincide within limits...