A5080784708- Telomeres, Telomerase, and Senescence
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Diet and metabolism studies
- Human Health and Disease
- Genetics, Aging, and Longevity in Model Organisms
- Healthcare Systems and Public Health
- Blood Pressure and Hypertension Studies
- Gut microbiota and health
- Nutritional Studies and Diet
- Cardiovascular Health and Risk Factors
- Long-Term Effects of COVID-19
- Nutrition and Health in Aging
- Biomarkers in Disease Mechanisms
- Frailty in Older Adults
- Cardiovascular Function and Risk Factors
- Birth, Development, and Health
- Cerebrovascular and Carotid Artery Diseases
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Growth Hormone and Insulin-like Growth Factors
- Muscle Physiology and Disorders
- Vitamin D Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
Pirogov Russian National Research Medical University
2019-2025
Ministry of Health of the Russian Federation
2015-2025
Lomonosov Moscow State University
2015-2024
Russian Scientific Center of Surgery
2021
National Medical and Surgical Center named after N.I. Pirogov
2020
Moscow State University
2015-2019
National Research Center for Preventive Medicine
2012-2018
Arterial ageing is characterized by increasing arterial stiffness as measured pulse wave velocity (PWV). This process enhanced in participants with early vascular (EVA), but slowed healthy (HVA). We aimed to describe characteristics of EVA and HVA a transcontinental study including 11 cohorts.In all, 18 490 from the global MARE Consortium, free cardiovascular disease, participated data on PWV cardiometabolic risk factors. defined lowest 10% highest standardized distribution, adjusted for age...
The aim of this paper was to study gut microbiota composition in patients with different metabolic statuses.92 participants aged 25⁻76 years (26 whom were men), confirmed absence cardiovascular and other chronic diseases (but the possible presence risk factors) included. Carotid ultrasound examinations, 16S rRNA sequencing stool samples diet assessments performed. Statistical analysis performed using R programming language, 3.1.0.Enterotyping yielded two clusters differentiated by...
BACKGROUND . More than one hundred candidate genes have been associated with longevity, including APOE, FOXO1A, GF1, IGF1, INCR, TP53, etc. Despite extensive research, the precise molecular and genetic underpinnings remain elusive due to low reproducibility of findings. Moreover, most studies focused on exomes neglected intergenic regulatory regions DNA. AIM To examine basis longevity create a prognostic model that assesses chance reaching age 90. MATERIALS AND METHODS study predictors...
BACKGROUND . A trend toward demographic aging of the population is currently observed in most countries worldwide. More and more people are achieving longevity, both due to environmental factors lifestyle, as well molecular genetic processes. Few large-scale studies have examined all contributing longevity Russia globally. Fewer them used a multi-omics approach, which could provide better insight into phenomenon by integrating genomic, epigenomic, transcriptomic metagenomic data. AIM. To...
Background Chronic inflammation and oxidative stress might be considered the key mechanisms of aging. Insulin resistance (IR) is a phenomenon related to inflammatory stress. We tested hypothesis that IR may associated with cellular senescence, as measured by leukocyte telomere length (LTL), arterial stiffness (core feature aging), carotid-femoral pulse wave velocity (c-f PWV). Methods The study group included 303 subjects, mean age 51.8 ±13.3 years, free known cardiovascular diseases regular...
Geriatric syndromes (GSs) and aging-associated diseases (AADs) are common side effects of aging. They affecting the lives millions older adults placing immense pressure on healthcare systems economies worldwide. It is imperative to study factors causing these conditions develop a holistic framework for their management. The so-called long-lived individuals-people over age 90 who managed retain much health functionality-could be holding key understanding implications. We analyzed status...
Aging is a natural process with varying effects. As we grow older, our bodies become more susceptible to aging-associated diseases. These diseases, individually or collectively, lead the formation of distinct aging phenotypes. Identifying these phenotypes and understanding complex interplay between coexistent diseases would facilitate personalized patient management, better prognosis, prolonged lifespan. Many studies distinguish successful frailty. However, this simple distinction fails...
Background . The trend towards aging of the population is global, which makes study etiology, prevention and treatment age-related disorders relevant. Increasing number studies highlights influence 25-hydroxyvitamin D deficiency on health state in older people, as well its correlation with geriatric syndromes prevalence. However, at moment it not known whether these patterns persist patients than 90 due to limited this population. Aim To assess prevalence vitamin a cohort centenarians...
Introduction With advancing age the left ventricle (LV) undergoes structural and functional changes, thereby creating substrate for development of diseases. One possible mechanism ageing heart is a cellular senescence. Leukocyte telomere length (LTL) marker replicative ageing. The purpose this study was to evaluate structure function LV in people different ages free cardiovascular diseases (CVD) regular drug medication assess their relationship with LTL. We hypothesized that age-related...
Background: Telomerase activity (TA) is considered as the biomarker for cardiovascular aging and diseases (CVDs). Recent studies suggest a link between statins telomere biology that may be explained by anti-inflammatory actions of their positive effect on TA. Until now, this has not been investigated in prospective randomized studies. We hypothesized 12 months atorvastatin therapy increased TA peripheral blood mononuclear cells. Methods: In randomized, placebo-controlled study 100...
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Objective The aim of the study was to assess inflammatory markers and clinical outcomes in adult patients admitted hospital with mild-to-moderate COVID-19 treated a combination standard-of-care (SOC) targeted immunosuppressive therapy including anti-IL-17A (netakimab), anti-IL-6R (tocilizumab), or JAK1/JAK2 inhibitor (baricitinib) alone. Methods observational cohort included 154 adults hospitalized between February August, 2020 RT-PCR-confirmed SARS-CoV-2 National Early Warning Score2...
The decline in functional capacity is unavoidable consequence of the process aging.While many anti-aging interventions have been proposed, clinical investigations into medicine are limited by lack reliable techniques for evaluating rate ageing.Here we present simple, accurate and cost-efficient estimation human biological age, Male Female Arterial Indices.We started with developing a model which accurately predicts chronological age.Using machine learning, arrived on set four predictors, all...
Biological age is a personalized measure of the health status an organism, organ, or system, as opposed to simply accounting for chronological age. To date, there have been known attempts create estimators biological based on various biomedical data. In this work, we focused developing approach assessing heart using echocardiographic The current study included data from more than 5,000 different cases. As result, created EchoAGE - neural network model determine age, that was tested patients...
It is known that glucose disturbances contribute to micro- and macrovascular complications vascular aging. Telomere length considered be a cellular aging biomarker. important determine the telomere role in structural functional changes patients with diabetes mellitus. We conducted cross-sectional observational study high-risk population from Moscow, Russia. The included 50 without clinical cardiovascular disease 49 control group participants. Glucose metabolism assessment tests, measuring...
Background: Increased arterial stiffness (AS), intima-media thickness (IMT), and the presence of atherosclerotic plaques (PP) have been considered as important aspects vascular aging. It is well documented that cardiovascular system an target organ for growth hormone (GH) insulin-like factor (IGF)-1 in humans, GH /IGF-1 deficiency significantly increases risk diseases (CVD). The telomere length peripheral blood leukocytes (LTL) a biomarker cellular senescence has proposed independent...
The authors discuss major structural and functional vascular changes accompanying ageing, the mechanisms of their development, potential methods correction.
A novel coronavirus infection SARS-CoV-2 (COVID19) is especially dangerous for elderly and senile patients. Preventive measures people should cover three areas: 1) direct prevention of the viral infection, 2) preservation functional status geriatric syndromes, including use social support measures, 3) control comorbidities. The clinical pattern COVID-19 in older patients may be atypical, while mildness symptoms (no fever, cough, shortness breath) not correspond to severity prognosis....
The aim was to assess the gut microbiota of long-livers from Moscow. This study included two groups patients who signed their consent participate. group (LL) 20 participants aged 97-100 years (4 men and 16 women). second 22 60-76 (6 men) without clinical manifestations chronic diseases (healthy elderly). Gut studied by 16S rRNA sequencing. Long-livers underwent a complex geriatric assessment as well expanded blood biochemistry. composition in cohorts also compared with microbiome Japan...
Aging puts the human body under an immense stress and makes it extremely susceptible to many diseases, often leading poor outcomes even death. Long-living individuals represent a unique group of people who withstood time offer abundance information on body's ability endure pressure aging. In this study, we sought identify predictors overall one-year mortality in 1641 long-living individuals. Additionally, analyzed risk factors for COVID-19-related morality, since statistics demonstrated...
Hyperferritinemia in patients with COVID-19 is associated liver dysfunction and an increased risk of the “cytokine storm”. The polypeptide preparation Laennec (6 ml per 350 0.9% NaCl solution, iv, cap. first 3 days, from 4 days — 6 250 solution) was used 14 (age 39–86 years old, men, 8 women) a long, stagnant course as hepatoprotector immunomodulator part complex therapy until stable remission achieved. Patients control group (n = 14) received only standard therapy. use led to positive...
Background . Life expectancy is increasing around the globe. However, chronological age not best indicator of health. For a more accurate assessment body condition throughout life, in general, and aging, particular, identify potential points geroprotective intervention, specialized tool needed. A that could prove beneficial biological calculator, utilizing range biomarkers to analyze degree functional preservation body. Many existing calculators are limited by small number parameters...