A5056069818- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Sodium Intake and Health
- Lipoproteins and Cardiovascular Health
- Hormonal Regulation and Hypertension
- Cardiac, Anesthesia and Surgical Outcomes
- Nutritional Studies and Diet
- Hemodynamic Monitoring and Therapy
- Acute Myocardial Infarction Research
- Cardiovascular and exercise physiology
- Diet and metabolism studies
- Protease and Inhibitor Mechanisms
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Disease and Adiposity
- Diabetes Treatment and Management
- Cardiac Health and Mental Health
- Health Systems, Economic Evaluations, Quality of Life
University of Southern Denmark
2016-2025
Holbæk Sygehus
2016-2025
Steno Diabetes Centers
2004-2025
University of Copenhagen
2008-2025
Lurie Children's Hospital
2025
Odense University Hospital
2015-2024
Rigshospitalet
2002-2024
Copenhagen University Hospital
2002-2024
Forskning.no (Norway)
2024
Region of Southern Denmark
2022
The ESH/ESC Guidelines represent the views of ESH and ESC were arrived at after careful consideration available evidence time they written.Health professionals are encouraged to take them fully into account when exercising their clinical judgement.The guidelines do not, however, override individual responsibility health make appropriate decisions in circumstances patients, consultation with that patient, where necessary patient's guardian or carer.It is also professional's verify rules...
Abbreviations ACE: angiotensin-converting enzyme; BP: blood pressure; DBP: diastolic eGFR: estimated glomerular filtration rate; ESC: European Society of Cardiology; ESH: Hypertension; ET: endothelin; IMT: carotid intima-media thickness; JNC: Joint National Committee; LVH: left ventricular hypertrophy; LVM: mass; PDE-5: phosphodiesterase-5; PPAR-γ: peroxisome proliferators-activated receptor-γ; PWV: pulse wave velocity; SBP: systolic WHO: World Health Organization. Introduction In the 2...
ACEangiotensin-converting enzymeBPblood pressureDBPdiastolic blood pressureeGFRestimated glomerular filtration rateESCEuropean Society of CardiologyESHEuropean HypertensionETendothelinIM...
Few data are available to clarify whether changes in albuminuria over time translate cardiovascular risk. The aim of the present study was examine during 4.8 years antihypertensive treatment were related risk 8206 patients with hypertension and left ventricular hypertrophy Losartan Intervention For Endpoint reduction (LIFE) study. Urinary albumin/creatinine ratio (UACR) measured at baseline annually. Time-varying closely for primary composite end point (ie, when UACR decreased treatment,...
Background There has been uncertainty about the risk of new-onset diabetes in hypertensive individuals treated with different blood pressure-decreasing drugs. Objectives To study this who were at developing mellitus Losartan Intervention For Endpoint reduction hypertension (LIFE) study. Methods In LIFE study, a double-masked, randomized, parallel-group design, 9193 patients (46% men) (mean age 67 years, average pressure 174/98 mmHg after placebo run-in) and electrocardiogram-documented left...
Low-grade inflammation is thought to contribute the development of cardiovascular disease (CVD), type-2 diabetes mellitus (T2D), cancer and mortality. Biomarkers may aid in risk prediction enable early intervention prevention disease.The aim this study was investigate whether plasma levels inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) are predictive mortality general population.This an observational prospective cohort study. Cohort participants were included...
It is unclear whether subclinical vascular damage adds significantly to Systemic Coronary Risk Evaluation (SCORE) risk stratification in healthy subjects. In a population-based sample of 1968 subjects without cardiovascular disease or diabetes not receiving any cardiovascular, anti-diabetic, lipid-lowering treatment, aged 41, 51, 61, 71 years, we measured traditional factors, left ventricular (LV) mass index, atherosclerotic plaques the carotid arteries, carotid/femoral pulse wave velocity...
The aim of the present study was to extend our understanding international trends in stroke and major sequelae Europe countries peripheral by assessing: (1) current mortality rates, (2) most recent 15-year prevalence trends, (3) relationship between systolic blood pressure community surveys national mortality. Data were obtained from World Health Organization (WHO www.who.int/whosis/database/mort/table.cfm), represent vital statistics as reported 39 (European Central Asian countries) using a...
Elevated blood pressure greatly contributes to cardiovascular deaths in low-income and middle-income countries. We aimed investigate the effectiveness of a population-level intervention led by existing community health workers reducing burden hypertension population.We did community-based, open-label, two-group, cluster-randomised controlled trial Nepal. Using computer-generated codes, we randomly assigned (1:1) 14 clusters lifestyle female volunteers (FCHVs) or usual care (control group)....
Carotid-femoral pulse wave velocity (cfPWV) adds significantly to traditional cardiovascular risk prediction, but is not widely available. Therefore, it would be helpful if cfPWV could replaced by an estimated carotid-femoral (ePWV) using age and mean blood pressure, previously published equations. The aim of this study was investigate whether ePWV predict events independently factors and/or cfPWV.cfPWV measured calculated in 2366 patients from four groups the Danish MONICA10 cohort....
Identification of individuals at high risk for atherosclerotic cardiovascular disease within the population is important to inform primary prevention strategies.
Background— Sudden cardiac death (SCD) occurs more often in patients with ECG left ventricular (LV) hypertrophy. However, whether LV hypertrophy regression is associated a reduced risk of SCD remains unclear. Methods and Results— The Losartan Intervention for End Point Reduction Hypertension (LIFE) study included 9193 55 to 80 years age essential hypertension by gender-adjusted Cornell product (CP) (RaVL+SV 3 [+6 mm women]) · QRS duration>2440 ms) and/or Sokolow-Lyon voltage (SLV) (SV 1...
Objective To investigate the influence of age and gender on prevalence cardiovascular disease (CVD) risk in Europeans presenting with Metabolic Syndrome (MetS). Methods Using 36 cohorts from MORGAM-Project baseline between 1982–1997, 69094 men women aged 19–78 years, without known CVD, were included. During 12.2 years follow-up, 3.7%/2.1% men/women died due to CVD. The corresponding percentages for fatal nonfatal coronary heart (CHD) stroke 8.3/3.8 3.1/2.5. Results MetS, according modified...
This study investigates age-related shifts in the relative importance of systolic (SBP) and diastolic (DBP) blood pressures as predictors stroke whether these relations are influenced by other cardiovascular risk factors. Using 34 European cohorts from MOnica, Risk, Genetics, Archiving, Monograph (MORGAM) Project with baseline between 1982 1997, 68 551 subjects aged 19 to 78 years, without disease not receiving antihypertensive treatment, were included. During a mean 13.2 years follow-up,...
Arterial ageing is characterized by increasing arterial stiffness as measured pulse wave velocity (PWV). This process enhanced in participants with early vascular (EVA), but slowed healthy (HVA). We aimed to describe characteristics of EVA and HVA a transcontinental study including 11 cohorts.In all, 18 490 from the global MARE Consortium, free cardiovascular disease, participated data on PWV cardiometabolic risk factors. defined lowest 10% highest standardized distribution, adjusted for age...
Arterial inflammation and vascular calcification are regarded as early prognostic markers of cardiovascular disease (CVD). In this study we investigated the relationship between CVD risk arterial (18F-FDG PET/CT imaging), metabolism (Na18F calcium burden (CT imaging) thoracic aorta in a population at low risk. Study participants underwent blood pressure measurements, analyses, 18F-FDG Na18F imaging. addition, 10-year for development CVD, based on Framingham score (FRS), was estimated....
To examine whether the 1-h blood glucose measurement would be a more suitable screening tool for assessing risk of diabetes and its complications than 2-h measurement.We conducted prospective population-based cohort study 4,867 men, randomly selected from prespecified birth cohorts between 1921 1949, who underwent an oral tolerance test with measurements at 0, 1, 2 h. Subjects were followed up to 39 years, registry-based recording events. Discriminative abilities elevated (≥8.6 mmol/L)...