A5065408495- Ethics in Clinical Research
- Healthcare Systems and Public Health
- Health and Medical Research Impacts
- Human Health and Disease
- Law, AI, and Intellectual Property
- Biomedical and Engineering Education
- Digital Transformation in Law
- Cardiovascular Health and Risk Factors
- Science, Research, and Medicine
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Genomics and Rare Diseases
- Forensic and Genetic Research
- Artificial Intelligence in Healthcare and Education
- Complementary and Alternative Medicine Studies
- Gut microbiota and health
- Blood Pressure and Hypertension Studies
- Genetics, Bioinformatics, and Biomedical Research
- Biomedical Ethics and Regulation
- Environmental DNA in Biodiversity Studies
- Animal testing and alternatives
- Atrial Fibrillation Management and Outcomes
- Technology Assessment and Management
- Dementia and Cognitive Impairment Research
- Climate Change and Health Impacts
National Research Center for Preventive Medicine
2019-2020
Ministry of Health of the Russian Federation
2019-2020
Previous studies have shown significant differences in the health status of population depending on place residence. Despite ongoing preventive measures, there is no improvement epidemiological situation relation to noncommunicable diseases, including due unfavorable living conditions. This study a continuation following earlier studies: Epidemiology Cardiovascular Diseases Regions Russian Federation (ESSE-RF) and ESSE-RF-2. Aim. To assess prevalence cardiovascular various risk factors (RFs)...
Aim. To study the epidemiological characteristics and changes of hypertension (HTN), as well factors associated with HTN in Russian population aged 35-74 years. Material methods. The Epidemiology Cardiovascular Diseases their Risk Factors Regions Federation-3 (ESSE-RF3) examined a representative sample years 15 regions response >70% (n=28611). Modular design questionnaire was used. Blood pressure (BP) measured twice after 5-minute rest sitting position on right arm an Omron blood monitor....
Aim. To study the prevalence of non-alcoholic fatty liver disease (NAFLD) and its association with cardiovascular risk factors (RFs). Material methods. The database from ESSE-RF2 ESSE-RF3 epidemiological studies was used, including data surveys population aged 35-64 years in 18 Russian regions (n=21204). assess NAFLD, index (FLI) used. Statistical analysis performed using statistical programming language R environment (version 3.6.1) open-source code. significance level for all tested...
The research biobanking field is developing rapidly in Russia. Over the course of last decade, numerous biobanks were created or formed from existing collections human and environmental biospecimens. Russian National Association Biobanks Biobanking Specialists (NASBIO) was established December 2018, aiming to: (1) unite professionals centers to create develop a network Russia; (2) provide services expertise biobanking; (3) execute various projects utilizing biobanks' infrastructure; (4)...
Aim. To study the prevalence of dyslipidemias and their association with various risk factors in Russian population men women aged 35-74 years 2020-2022. Material methods. This work was carried out as part Epidemiology Cardiovascular Diseases Risk Factors Regions Federation-3 (ESSE-RF3) study. The sample included 28731 living 15 regions. Hypercholesterolemia (HC) diagnosed total cholesterol (TC) ≥5,0 mmol/l, while elevated low-density lipoprotein (LDL-C) considered ≥3,0 hypertriglyceridemia...
Aim. To study the problem of obesity at national level. Material and methods. The ESSE-RF3 examined a representative sample population 15 Russian regions aged 35-74 years with response >70% (n=28731). Modular design questionnaire was used. received approval from Independent Ethics Committee National Medical Research Center for Therapy Preventive Medicine. Signed informed consent obtained each participant. Body mass (BM) measured once an accuracy 100 g. height 0,5 cm in standing position...
Aim. To analyze the structure of clinical data, as well principles collecting and storing related data biobank National Medical Research Center for Therapy Preventive Medicine (hereinafter Biobank). Material methods . The analysis was carried out using documentation available in Biobank, databases used its work. paper presents on biosamples Biobank August 18, 2021. Results. At time analysis, had 373547 samples collected from 54192 patients within 37 research projects. article representation...
The success and quality of large-scale epidemiological studies depends entirely on biomaterial quality. Therefore, when arranging the third Epidemiology Cardiovascular Diseases their Risk Factors in Regions Russian Federation (ESSE-RF-3) study, increased attention was paid to specifics collection, processing further transportation biological samples related clinical anthropometric data participants from regional collection centers Biobank. Aim . To develop a methodology for high-quality...
Aim. To analyze the prevalence of anxiety and depression in Russians using Hospital Anxiety Depression Scale (HADS) during Epidemiology Cardiovascular Diseases their Risk Factors Regions Russian Federation (ESSE-RF) study. study associations increased levels (HADS-A/ HADS-D ≥8+) with demographic socio-economic characteristics according to ESSE-RF3 Material methods. In study, a representative sample population 15 regions aged 35-74 years was examined response >70%. After removing...
Aim. To assess the prevalence of psychological stress (PS) using Perceived Stress Scale-10 (PSS-10) in various Russian regions and to analyze PS associations with socio-demographic characteristics behavioral risk factors some non-communicable diseases (NCDs). Material methods. We studied representative samples population aged 35-74 years regions, examined as part Epidemiology Cardiovascular Diseases Regions Federation-3 (ESSE-RF3) study. The subjects were interviewed a questionnaire...
The biobank is a structure established with the goal of long-term responsible storage biological samples and associated data for their further use in scientific clinical research. objectives biobanking are creation unified recommendations on: planning premises selection equipment storage; development management methods staff training; standardization collection, shipping, processing biomaterial various origins, as well quality control validation applied methods; databases information...
Currently one of the most important problems facing biobanking specialists is standardization biobanks operation. Close attention paid to this issue by international organizations, such as ISBER and BBMRI-ERIC, which develop regulatory documentation in area. The article provides examples tools - implementation ISO 9001 quality standard Best Practices. General information about development, scope, structure 20387 provided. does not provide ready-made solutions contain specific requirements...
Aim . To create the concept of national information platform biobanks Russian Federation (NIPB RF). Material and methods In April 2022, an expert group consisting 17 representatives was formed in National Association Biobanks Biobanking Specialists to NIPB RF. An analysis international practices this area carried out. assess infrastructure terms support for stored biomaterial, experts a questionnaire several blocks questions. The survey conducted from June 2022 among biobanks. Descriptive...
This paper provides several definitions of the term "biobank"; a list standards developed by International Organization for Standardization (ISO) applicable to activities biobanks; analyzes legal and ethical requirements; Russian framework in field biobanking, best international practices recommendations; describes experience development implementation quality management systems according ISO 9001 Biobanks established different countries, Bank Biological Material National Medical Research...
The search for early disease markers and the development of diagnostic systems has recently been expanding within genomics. Genomic deoxyribonucleic acid (DNA), cell-free DNA (cfDNA) microbiome obtained from different types samples (tissues, blood its derivatives, feces, etc.) are used as objects genetic research. It shown that cfDNA enters bloodstream, in particular, a result apoptosis, necrosis, active tumor secretion metastasis, is great importance studying molecular mechanisms...
Aim. To develop an algorithm and manage total biobanking of samples whole blood, serum plasma patients in the hospital National Medical Research Center for Therapy Preventive Medicine order to create a detailed biosample collection through integration electronic medical records biobank database. Material methods. The study includes all admitted various departments who signed informed consent biobanking. Clinical information is collected as part patient examination stored Medialog system....
One technology that helps overcome the problem of low research reproducibility is biobanking, which involves maintaining strict quality standards at all stages. In addition to data on biosample (detailed documentation sampling, transportation, preparation and subsequent storage), one key points availability information about donor (patient). The aim this article was analyze creating clinical abstract biospecimens, combining from various biobanks assessing possibilities electronic medical...
The advances of biomedicine include the new technologies, diagnosis and treatment techniques, as well practical use types biological targets, in particular, nucleic acids. Genomic deoxyribonucleic acid (DNA), extracellular DNA (exDNA) microbiome obtained from different samples (tissues, blood its derivatives, feces, etc.) are used objects genetic research. technologies for analysis required development standardized methods processing order to obtain high-quality samples. research uses...
Biosample preservation for future research is a fundamental component of translational medicine. At the same time, value stored biosamples largely determined by presence related clinical data and other information. Electronic medical records are unique source large amount information received over long period time. In this regard, genetic types obtained from biosample analysis can be associated with phenotypic in electronic records, which pushes boundaries large-scale improves healthcare....
Aim. To present an approach to collection of biosamples patients with rare and scientifically interesting clinical situations for solving the problems personalized medicine, as well analyze related 8-year experience. Material methods . The a blood its derivatives is developed at National Medical Research Center Therapy Preventive Medicine within project "Interesting Cases Medicine". biomaterial from was carried out on planned basis inpatient department, upon referral outpatient doctors. All...
Information on morbidity is presented in statistical reports for the entire population of multinational subjects Russia, but Biobanks contain information individual peoples. Aim. To develop a technology assessing frequency deoxyribonucleic acid (DNA) markers administrative units based indigenous data, which will make it possible to assess relationship between DNA and morbidity. Material methods . The Biobank Northern Eurasia frequencies 24 associated with cardiovascular disease (CVD) 86...
To implement a modern personalized approach in practical healthcare, the latest biomedical technologies should be developed and genetic research performed. The analysis of substantial quantity data is essential for investigation prevalence risk factors various diseases, drug resistance genes, development panels to determine individual pathologies, as well creation scores. review demonstrates through use illustrative examples that contemporary biobanks have become vital component field...
In connection with the development of genetic and other types research in translational medicine, collections containing a significant number biospecimens large data sets are required. Since in-depth examination patients is most often carried out during hospitalization, creation based on electronic medical records (EMR) promising. this regard, project "Total biobanking hospital National Medical Research Center for Therapy Preventive Medicine" was initiated, aimed at total blood related...
Aim . To create and validate an algorithm for automatic aliquoting of serum plasma samples biobanking as part a large-scale study. Material methods Biobank the National Medical Research Center Therapy Preventive Medicine is equipped with Tecan automated system. When compiling program (script), following parameters were selected: time spent on spotting one complete cryobox, capacity 96 cryotubes, optimal number vacutainers tips single loading device. The was created to receive 12 aliquots 0,5...