A5102998358- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- CRISPR and Genetic Engineering
- Tissue Engineering and Regenerative Medicine
- RNA Research and Splicing
- Neurological Disease Mechanisms and Treatments
- Animal Genetics and Reproduction
- RNA and protein synthesis mechanisms
- Ethics in Clinical Research
- Congenital heart defects research
- Nerve injury and regeneration
- Epigenetics and DNA Methylation
- TGF-β signaling in diseases
- Telomeres, Telomerase, and Senescence
- Treatment of Major Depression
- Neurological Disorders and Treatments
- Circadian rhythm and melatonin
- Light effects on plants
- Wound Healing and Treatments
- Angiogenesis and VEGF in Cancer
- Electrospun Nanofibers in Biomedical Applications
- Traumatic Brain Injury and Neurovascular Disturbances
Institute of Cytology
2009-2016
Federal Almazov North-West Medical Research Centre
2009-2015
Ministry of Health of the Russian Federation
2013-2014
Lund University
2004-2012
Russian Academy of Sciences
2010
National Institutes of Health
2001-2008
National Institute on Aging
2001-2008
Wallenberg Wood Science Center
2004-2007
St. Petersburg Institute of Bioregulation and Gerontology
2002-2004
Shanghai Institutes for Biological Sciences
2002
Abstract Human embryonic stem cells (hESCs) have been proposed as a source of dopamine (DA) neurons for transplantation in Parkinson's disease (PD). We investigated the effect vitro predifferentiation on vivo survival and differentiation hESCs implanted into 6-OHDA (6-hydroxydopamine)-lesion rat model PD. The were cocultured with PA6 16, 20, or 23 days, leading to DA neurons. Grafted hESC-derived survived well expressed neuronal markers. However, very few exhibited neuron phenotype. Reversal...
Blood vessels and adjacent cells form perivascular stem cell niches in adult tissues. In this niche, a with mesenchymal characteristics was recently identified some somatic These are pericytes that line the microvasculature, express markers differentiate into mesodermal lineages but might even have capacity to generate tissue-specific types. Here, we isolated, purified characterized previously unrecognized progenitor population from two different regions human brain, ventricular wall...
Bone marrow (BM) and subcutaneous adipose tissue (Ad) are both considered being prospective sources of MSC for therapeutic applications. However, functional properties efficacy derived from different tissues the same patient still poorly investigated. In our study, BM-MSC F-MSC cultures 43 adult donors were evaluated in successive passages immunophenotype, secretion VEGF, SDF1, MCP1, IL6 TGFβ1, frequency colony-forming units (CFU-F), adipo- osteo-progenitors (CFU-Ad, CFU-Ost), onset vitro...
The research biobanking field is developing rapidly in Russia. Over the course of last decade, numerous biobanks were created or formed from existing collections human and environmental biospecimens. Russian National Association Biobanks Biobanking Specialists (NASBIO) was established December 2018, aiming to: (1) unite professionals centers to create develop a network Russia; (2) provide services expertise biobanking; (3) execute various projects utilizing biobanks' infrastructure; (4)...
Summary This study aimed to investigate the effect of bone marrow‐ and adipose tissue‐derived mesenchymal stem cell ( BM ‐ MSC AD respectively) transplantation on left ventricular function infarct area IA ) in rat model ischaemic heart failure. In anaesthetized Wistar rats, coronary artery LCA was occluded for 40 min with subsequent reperfusion 7 days. Seven days following surgery, animals occlusion/reperfusion were randomized into three groups: (i) Controls received intramyocardial...
ORIGINAL RESEARCH article Front. Neuroanat., 30 December 2007 | https://doi.org/10.3389/neuro.05.004.2007
We investigated the Gln --> Arg 191 polymorphism in paraoxonase (PON1) St. Petersburg population, three clinically differentiated groups of patients with Parkinson's disease (PD) and symptomatic tremor group. A new approach for PON1 genotyping is suggested. No significant differences studies as compared to controls was observed.
The era of COVID-19 has brought about a number novel challenges for the global biobanking community. To better position community to cope with current and future challenges, International Society Biological Environmental Repositories (ISBER) Response Task Force was convened identify needs gaps in tools (existing resources that support good practice), example, standards, best practices, business, etc. make recommendations benefit Toward these goals, assembled set questions explore individual...
Human stem cells are viewed as a possible source of neurons for cell-based therapy neurodegenerative disorders, such Parkinson's disease. Several protocols that generate different types from human (hSCs) have been developed. Nevertheless, the cellular mechanisms underlie development in vitro they subjected to specific differentiation often poorly understood. We designed focused DNA (oligonucleotide-based) large-scale microarray platform (named "NeuroStem Chip") and used it study gene...
Early initiation of enteral feeding is recognized to play a crucial role in improving the outcomes treatment acute pancreatitis. However, method administration nutrition remains debatable. We present experience treating patient with moderate-severe pancreatitis, at high risk progressing severe or fatal condition, using novel selective duodenal isolation.