A5065642819- Pulmonary Hypertension Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Ischemia and Reperfusion
- Mesenchymal stem cell research
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Neurological Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Cardiac Fibrosis and Remodeling
- Heart Rate Variability and Autonomic Control
- Mitochondrial Function and Pathology
- Colorectal Cancer Surgical Treatments
- Phytochemistry and Biological Activities
- Radiomics and Machine Learning in Medical Imaging
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Liver physiology and pathology
- Hemoglobin structure and function
- Vagus Nerve Stimulation Research
- Heart rate and cardiovascular health
- Erythrocyte Function and Pathophysiology
- Cardiac Structural Anomalies and Repair
Federal Almazov North-West Medical Research Centre
2016-2025
Pharmaceutical Formulations (United States)
2021-2025
Saint Petersburg State Electrotechnical University
2023-2025
Institute of Experimental Medicine
2013-2024
Saint - Petersburg State Chemical Pharmaceutical Academy
2022-2023
Ministry of Health of the Russian Federation
1992-2023
Kola Science Centre
2020-2022
Murmansk Marine Biological Institute
2021-2022
Development Agency of Serbia
2022
Division of Chemistry
2022
Abstract Pulmonary hypertension (PH) is a syndrome complex that accompanies number of diseases different etiologies, associated with basic mechanisms structural and functional changes the pulmonary circulation vessels revealed pressure increasing in artery. The are main limiting factor determining prognosis patients PH. Thickening irreversible deposition collagen artery branches walls leads to rapid disease progression therapy effectiveness decreasing. In this regard, histological...
Aim . To develop a model of chronic thromboembolic pulmonary hypertension (CTEPH) in rats by embolization the vascular bed with microencapsulated fibrin (MF). Materials and methods Microencapsulated (MF) was prepared encapsulating particles smaller than 71 μm sodium alginate. Non-encapsulated particle size 71–200 µm used as an alternative embolic particle. Modeling performed on male Wistar rats. The animals were divided into 4 groups. Intact (INT) ( n = 7) administered normal saline...
The task of statistical data processing and presentation is not difficult for specialists in the field statistics, but it can require quite a lot time effort from novice specialists. article presents database transformation involving transposition rows columns followed by visualization using R programming language.
Summary This study aimed to investigate the effect of bone marrow‐ and adipose tissue‐derived mesenchymal stem cell ( BM ‐ MSC AD respectively) transplantation on left ventricular function infarct area IA ) in rat model ischaemic heart failure. In anaesthetized Wistar rats, coronary artery LCA was occluded for 40 min with subsequent reperfusion 7 days. Seven days following surgery, animals occlusion/reperfusion were randomized into three groups: (i) Controls received intramyocardial...
Summary A major translational barrier to the use of stem cell ( SC )‐based therapy in patients with myocardial infarction MI ) is lack a clear understanding mechanism(s) underlying cardioprotective effect s. Numerous paracrine factors from s may account for reduction infarct size, but salvage associated transdifferentiation into vascular cells as well cardiomyocyte‐like be involved too. In this study, bone marrow‐derived rat mesenchymal MSC s) were microencapsulated alginate preventing...
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare and life-threatening complication of embolism. As existing animal models CTEPH do not fully recapitulate complex disease pathophysiology, we report new rat model for evoked by repetitive embolization the distal artery branches with partially biodegradable alginate microspheres (MSs). MSs (180 ± 28 μm) were intravenously administered eight times at 4-day intervals; control animals received saline. The validity was confirmed using...
Recovery of the contractile function heart and regeneration myocardium after ischemic injury are contemporary issues in regenerative medicine cell biology. This study aimed to analyze early transcriptional events cardiac tissue infarction explore population that can be isolated from myocardial tissue. We induced Wistar rats by permanent ligation left coronary artery showed a change expression pattern Notch-associated genes Bmp2/Runx2 post-MI tissues using RNA sequencing RT-PCR. obtained...
According to global health statistics, respiratory diseases, together with infectious complications and hereditary lung rank as the third leading cause of death. Today, transplantation (LTx) is a well-recognized modality treatment for end-stage chronic disease. However, number LTx surgeries performed much lower than other solid organs. This due high requirements potential donor characteristics graft, reflecting efficiency gas exchange function. Non-compliance selection criteria leads...
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of acute embolism with poor clinical outcomes. Therapeutic approaches to prevention fibrotic remodeling the vascular bed in CTEPH are limited. In this work, we tested hypothesis that Janus kinase 1/2 (JAK1/2) inhibition ruxolitinib might prevent and attenuate rat model. was induced by repeated embolization artery partially biodegradable 180 ± 30 μm alginate microspheres. Two weeks after last injection microspheres,...
Respiratory diseases, together with infectious complications and hereditary lung rank third in international mortality statistics. Today, transplantation is a recognized method of treating end-stage diseases. However, the number transplant surgeries performed not much. This down to high requirements on condition potential donor directly quality lung. has significantly limited optimal donors. Rehabilitation lungs gas exchange indicators can be achieved objectively assessed course ex vivo...
Introduction. With the emergence of empagliflozin in pharmaceutical market, there has been an increase publications on primary and secondary pharmacodynamics drug, list potential indications for use this sodium-glucose co-transporter inhibitor is increasing. Hypotheses about pharmacological effects mechanisms their implementation are tested both large-scale clinical studies animal experiments. Aim. The purpose work was to study effectiveness by echocardiographic, histological molecular...
We present the results of experimental studies into pharmacological safety a pharmaceutical substance 4-[(3-oxo-3-ethoxypropanoyl)amino]benzoic acid (Etmaben) under single intragastric administration at various doses (60–3000 mg/kg) to female laboratory outbred rats. A clinical examination animals was carried out in order identify signs intoxication. To that end, level food and water consumption assessed biochemical blood tests were performed. In addition, state central nervous...
An entire cycle of preclinical studies 4-[(3-ethoxy-3-oxopropanoyl)amino]benzoic acid (etmaben) exhibiting cardiotropic action was carried out. Its potential mechanism and pharmacological effects, general toxic effects in acute chronic experiments, specific types toxicity (allergenicity, immunotoxicity, reproductive toxicity, mutagenicity), pharmacokinetics were studied. The drug found to have a pronounced effect positive safety profile, which justifies the launch phase I clinical trials.
Introduction. Chronic thromboembolic pulmonary hypertension (CTEPH) is one of the most severe complications embolism (PE), characterized by poor prognosis and insuffcient effectiveness standard treatment approaches. A small number representative models CTEPH make it diffcult to conduct preclinical studies promising pharmacological substances. Objective – development validation experimental model in rats embolization distal branches artery with biodegradable microspheres. Material methods....