A5091777618- Lipoproteins and Cardiovascular Health
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- Cardiac Health and Mental Health
- Pancreatic function and diabetes
- Circular RNAs in diseases
- Genetic Associations and Epidemiology
- Cardiovascular Disease and Adiposity
- Lipid metabolism and disorders
- Genomics and Rare Diseases
- MicroRNA in disease regulation
- Pharmaceutical Economics and Policy
- Health and Medical Research Impacts
- Health Systems, Economic Evaluations, Quality of Life
The literature review is devoted to circulating microRNA (small noncoding ribonucleic acid molecules) of blood plasma and serum, potential their use as new biomarkers coronary artery disease (CAD) at various stages. study results demonstrate different levels serum expression in patients with without CAD. In this regard, determination level for minimally invasive diagnosis CAD seems promising, well further prognosis progression. A list microRNAs has been compiled.
Aim . To characterize patients accessing lipid clinic and assess the efficiency of treatment in a specialized medical center. Material methods A retrospective analysis surviving records outpatients who visited National Research Center for Therapy Preventive Medicine (Moscow, Russia) 2011-2019 (n=675) was carried out. Cardiovascular risk (CVR) target lipoproteins levels were evaluated accordance with actual guidelines diagnostics correction dyslipidemias. Results The mediana age 57 [46;65]...
Aim . To study genetic causes of decreased low-density lipoprotein cholesterol (LDL-C) in Russian patients. Material and methods The included the following Epidemiology Cardiovascular Diseases their Risk Factors Regions Federation (ESSE-RF) participants: individuals with LDL-C<5th percentile, taking into account sex age (n=52), who underwent targeted sequencing protein-coding regions 6 genes (APOB, PCSK9, MTTP, ANGPTL3, SAR1B, APOC3) determination risk score (GRS) for...
Aim. To present an approach to collection of biosamples patients with rare and scientifically interesting clinical situations for solving the problems personalized medicine, as well analyze related 8-year experience. Material methods . The a blood its derivatives is developed at National Medical Research Center Therapy Preventive Medicine within project "Interesting Cases Medicine". biomaterial from was carried out on planned basis inpatient department, upon referral outpatient doctors. All...
Aim. Maturity- onset diabetes of the young (MODY) is a group monogenic diseases with an autosomal dominant inheritance. This rarely diagnosed disease, occurring in 1 10 thousand adults and 23 children. Brief description. We present case report patient HNF4A-MODY, severe hypertriglyceridemia, progressive premature coronary artery disease HNF4A gene pathogenic variant (ENST00000316099.8:c.1145dup). Discussion. demonstrates effectiveness triple hypoglycemic therapy, including empagliflozin for...