A5060060724- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Cardiovascular Disease and Adiposity
- Blood Coagulation and Thrombosis Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Atherosclerosis and Cardiovascular Diseases
- Cholesterol and Lipid Metabolism
- Oral microbiology and periodontitis research
- Infective Endocarditis Diagnosis and Management
- Nutritional Studies and Diet
- Diabetes and associated disorders
- Genetic Associations and Epidemiology
- Pharmaceutical Economics and Policy
- Platelet Disorders and Treatments
- Healthcare Systems and Public Health
- Genetic factors in colorectal cancer
- Cardiovascular Health and Risk Factors
- Advanced X-ray and CT Imaging
- Salivary Gland Disorders and Functions
- Nuclear Structure and Function
- Acute Myocardial Infarction Research
- Medical Imaging Techniques and Applications
- Biomarkers in Disease Mechanisms
St Petersburg University
2014-2023
Institute for Atherosclerosis Research
2011-2023
Federal Medical-Biological Agency
2011-2017
Aim. Russian multicenter register of familial hypercholesterolemia (FH) was transformed into Register patients with FH and very high cardiovascular risk insufficient effect hypolipidemic therapy (RENESSANS Registry) in 2017 The aim RENESSANS maximal inclusion not only FH, but also those atherosclerotic diseases (CVD), who did achieve targeted level low density lipoprotein cholesterol (LDL-C) using drug therapy. Material methods. Registry is an open, national, observing study that includes...
Familial hypercholesterolemia (FH) is caused by mutations in various genes, including the LDLR, APOB and PSCK9 genes; however, spectrum of these Russian individuals has not been fully investigated. In present study, mutation screening was performed on LDLR gene other FH-associated genes patients with definite or possible FH, using next-generation sequencing. total, 59 unrelated were recruited sorted into two separate groups depending their age: Adult (n=31; median age, 49; age range, 23-70)...
Цель работы. Изучить, как повлияет применение шкалы SCORE2 на оценку риска сердечно-сосудистых осложнений (ССО) у жителей Российской Федерации. Материал и методы: В исследование были включены 100 пациентов в возрасте от 40 до 65 лет (48 мужчин, средний возраст 55,2+7,1 года). Для каждого из включенных определены показатель фатального ССО по шкале SCORE (с последующим расчётом суммарного фатальных нефатальных соответствии с действующими рекомендациями) риск SCORE2. статистического анализа...
Цель. Целью исследования явилась оценка эффективности и приверженности гиполипидемической терапии, частоты развития сердечно-сосудистых осложнений у пациентов с гомо- гетерозиготной семейной гиперхолестеринемией (СГХС) в течение пятилетнего периода наблюдения регистре РЕНЕССАНС (Регистр СГХС очень высокого сЕрдечно-Сосудистого риска недоСтАточной эффективНоСтью, проводимой терапии). Материал методы. является открытым, национальным, наблюдательным исследованием включает больных СГХС....
In opinion the Expert council provides management tactics for patients with hypertriglyceridemia (HTG). It is demonstrated that HTG a common condition in overweight and an important component of residual risk. creates additional conditions progression atherosclerosis, so level triglycerides (TG) recommended to be measured high, very high extremely risk level. An indication appointment drugs reduce concentration TG its more than 2,3 mmol/L. Statins are agents choice cardiovascular disease...
Обзор посвящен особенностям диагностики и лечения дислипидемии у больных сахарным диабетом 2-го типа с целью предотвращения серьезных сердечно-сосудистых осложнений.
Aim . To analyze the results of measurements blood lipid spectrum urban residents European part Russian Federation. Material and methods The single assessment profiles in 22,436 males 35,100 females at age from 13 to 94 years 347 cities towns Federation were analyzed. Lipid assays performed by Laboratory Service «HELIX» 28 Jan 2015 19 Mar 2016. Statistical included descriptive statistics, analysis distributions sample comparisons search dependencies. Results. Results 56,235 total cholesterol...
The review considers changes in the structure and function of high-density lipoproteins (HDL), which play an important role pathogenesis a number chronic diseases that somehow stimulate development atherosclerosis. HDL has been shown to be impaired genetic acquired leading dyslipidemia associated with increased cardiovascular risk such as familial hypercholesterolemia, obesity, metabolic syndrome, kidney disease, diabetes mellitus, inflammatory autoimmune diseases.
Background. One of the urgent problem modern cardiology is search for markers to assess risk CV (cardiovascular) events in patients with CAD. Objective. To evaluate level von Willebrand factor (vWF) blood plasma early onset CAD and study relationship between vWF hyperproduction recurrent events. Design methods. We examined 80 who underwent acute myocardial infarction and/or surgical treatment amount percutaneous coronary intervention or artery bypass surgery at age up 55 years (men) 60...
High levels of high-density lipoproteins (HDL) in blood plasma have traditionally been considered an anti-atherogenic factor, but this opinion is not always supported by epidemiological and genetic studies. The functions are much greater importance, the main which implementation reverse cholesterol transport (RCT) from cells to liver. part 1 review presents sequence passage HDL, shows importance each link chain for development atherosclerosis; methods determining RCT given. Changes structure...