А. G. Soplenkova
A5023559865- Human Health and Disease
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Liver Disease Diagnosis and Treatment
- Healthcare Systems and Public Health
- Glycosylation and Glycoproteins Research
- Liver Disease and Transplantation
- Cardiac Health and Mental Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Risk Factors
- Smoking Behavior and Cessation
- Health Systems, Economic Evaluations, Quality of Life
- Lipid metabolism and disorders
- COVID-19 Clinical Research Studies
- Blood Coagulation and Thrombosis Mechanisms
- Health, psychology, and well-being
- Coronary Interventions and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Enzyme Structure and Function
- Blood Pressure and Hypertension Studies
- Diabetes and associated disorders
- Child and Adolescent Psychosocial and Emotional Development
- Extracellular vesicles in disease
- Cystic Fibrosis Research Advances
Lomonosov Moscow State University
2024-2025
Moscow State University
2024-2025
Aim. To evaluate the outcomes of 10-year follow-up patients with atrial fibrillation (AF) after hospitalization in various departments a multidisciplinary hospital and to determine most significant prognostic factors associated high death risk. Material methods . In outpatient registry RECVAZA-AF Tula discharge from hospital, for period 2013-2024 (follow-up, 7,9±3,7 years) were assessed 1159 AF (age, 69,2±9,8 years; men, 48,0%). Information on fatal was obtained Regional System Oblast....
Aim. To evaluate the efficacy and safety of single bolus administration non-immunogenic staphylokinase in comparison with placebo patients intermediatehigh risk pulmonary embolism (PE) within FORPE-2 clinical trial. Material methods . Non-immunogenic has high thrombolytic activity fibrin selectivity. The trial a multicenter, doubleblind, randomized, placebo-controlled design. In sites, (486 total, possible 10% dropout rate) confirmed PE evidence right ventricular dysfunction based on...
Aim. To study the prevalence of non-alcoholic fatty liver disease (NAFLD) and its association with cardiovascular risk factors (RFs). Material methods. The database from ESSE-RF2 ESSE-RF3 epidemiological studies was used, including data surveys population aged 35-64 years in 18 Russian regions (n=21204). assess NAFLD, index (FLI) used. Statistical analysis performed using statistical programming language R environment (version 3.6.1) open-source code. significance level for all tested...
Aim. To assess the prevalence of non-alcoholic fatty liver disease (NAFLD) using obesity index — FLI (Fatty Liver Index), and to study its associations with socio-demographic indicators behavioral risk factors for NAFLD. Material methods . The data from multicenter ESSE-RF (Epidemiology cardiovascular diseases in regions Russian Federation) samples unorganized male female population aged 25-64 years were used. 5,161 respondents included, which 2,275 (44,1%) men. NAFLD, was used, calculated...
Aim. To investigate the association of 10 circulating plasma microRNAs with collateral flow degree in chronic total occlusion (CTO) patients coronary artery disease (CAD). Materials and methods. Plasma expression levels miRNAs were measured by real-time PCR using Taqman technology a sample 43 subjects. The study included CAD CTO good (n=13) or poor (n=10) circulation (CCC) based on Rentrop classification control group without significant stenosis (n=20). Results. Significant differences...
Aim. To analyze the prevalence of anxiety and depression in Russians using Hospital Anxiety Depression Scale (HADS) during Epidemiology Cardiovascular Diseases their Risk Factors Regions Russian Federation (ESSE-RF) study. study associations increased levels (HADS-A/ HADS-D ≥8+) with demographic socio-economic characteristics according to ESSE-RF3 Material methods. In study, a representative sample population 15 regions aged 35-74 years was examined response >70%. After removing...
Aim. To assess the prevalence of psychological stress (PS) using Perceived Stress Scale-10 (PSS-10) in various Russian regions and to analyze PS associations with socio-demographic characteristics behavioral risk factors some non-communicable diseases (NCDs). Material methods. We studied representative samples population aged 35-74 years regions, examined as part Epidemiology Cardiovascular Diseases Regions Federation-3 (ESSE-RF3) study. The subjects were interviewed a questionnaire...
Aim . To assess the safety and efficacy of a single intravenous bolus non-immunogenic staphylokinase compared with alteplase in patients massive pulmonary embolism hemodynamic instability. Non-immunogenic is modified recombinant low immunogenicity, high thrombolytic activity fibrin selectivity. Material methods This multicenter, open-label, randomized, comparative clinical trial FORPE two parallel groups was conducted 23 centers Russia. A total 310 aged 18 years older instability computed...
Aim. To validate and evaluate the accuracy of 15 genetic risk scores (GRSs) for obesity, created in populations European origin sample two Russia regions. Material methods. Genetic testing has been performed using next generation sequencing on a from Russian population (n=1179). The study included GRS associated with body mass index (BMI) or waist-to-hip ratio adjusted BMI (WHRadjBMI). Results. predictive power 8 out 9 GRSs obesity based remains same population. 6 WHRadjBMI is lower than...
Abstract More than a half of plasma proteins are N-glycosylated. Most them synthesized, glycosylated, and secreted to the bloodstream by liver lymphoid tissues. While associations with N-glycosylation implicated in rising number liver, cardiometabolic, immune diseases, little is known about genetic regulation this process. Here, we performed largest genome-wide association study blood proteome 10,000 individuals. We doubled loci be associated identifying 16 novel prioritizing 13 genes...
Aim . To study genetic causes of decreased low-density lipoprotein cholesterol (LDL-C) in Russian patients. Material and methods The included the following Epidemiology Cardiovascular Diseases their Risk Factors Regions Federation (ESSE-RF) participants: individuals with LDL-C<5th percentile, taking into account sex age (n=52), who underwent targeted sequencing protein-coding regions 6 genes (APOB, PCSK9, MTTP, ANGPTL3, SAR1B, APOC3) determination risk score (GRS) for...
N-glycome analysis of individual proteins and tissues is crucial for fundamental applied biomedical research medical diagnosis plays an important role in the evaluation quality biopharmaceutical biotechnological products. The interest this area continues to grow annually, thereby increasing demand high-throughput profiling human blood plasma N-glycome. In response need, we have developed optimized, simple, rapid protocol proteins. This encompasses entire cycle, from isolation N-glycan...
Aim. To evaluate the quality of drug treatment patients with cardiovascular diseases (CVD) at remote stage follow-up after hospitalization for new coronavirus infection (COronaVIrus Disease 2019, COVID-19) within framework prospective TARGET-VIP registry. Material and methods. 1,130 people were included in The 473 (54.8%) CVD selected 863 discharged from hospital a diagnosis COVID-19. Results. frequency proper prescriptions medicines upon discharge was 60%, 3 years this indicator decreased...
Aim. To validate and evaluate the accuracy of 14 genetic risk scores (GRSs) for type 2 diabetes (T2D), created earlier in other countries, using a Russian population sample from biobank National Medical Research Center Therapy Preventive Medicine. Material methods. For analysis, next generation sequencing data was used on (n=1165) based collection. The study included GRSs associated with T2D. Results. demonstrated that predictive power 12 out T2D replicated population. As quality metrics, we...