A5060148780- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
- Diet and metabolism studies
- Gut microbiota and health
- Liver Disease and Transplantation
- Body Composition Measurement Techniques
- Bariatric Surgery and Outcomes
- Neuropeptides and Animal Physiology
- Apelin-related biomedical research
- Clostridium difficile and Clostridium perfringens research
- Cardiac Health and Mental Health
- Bone health and osteoporosis research
- Alcohol Consumption and Health Effects
- Chronic Disease Management Strategies
- Respiratory and Cough-Related Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Folate and B Vitamins Research
- Adipose Tissue and Metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Bone Metabolism and Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hemodynamic Monitoring and Therapy
- Pediatric health and respiratory diseases
- Bone health and treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
National Research Center for Preventive Medicine
2022-2024
City Clinical Hospital
2017
Objective. To characterize and compare myokine profiles in patients with obesity depending on the presence of sarcopenia. Materials Methods. The study included 77 examined at National Medical Research Center for Therapy Preventive Medicine Ministry Health Russia from January 2023 to April 2024. Sarcopenia was diagnosed using criteria including handgrip strength, skeletal muscle mass, physical function assessment. Serum erythroferrone, irisin, myostatin, interleukin (IL)-6 were assessed...
Non-alcoholic fatty liver disease (NAFLD) is considered the most common chronic worldwide, affecting nearly 25% of global adult population. Increasing evidence suggests that functional and compositional changes in gut microbiota may contribute to development promote progression NAFLD. 16S rRNA gene next-generation sequencing widely used determine specific features NAFLD microbiome, but a complex system such as requires comprehensive approach. We three different approaches: MALDI-TOF-MS...
Non-alcoholic fatty liver disease (NAFLD) is often thought of as clinically asymptomatic. However, many NAFLD patients complain fatigue and low mood, which may affect their quality life (QoL). This create a barrier to weight loss hinder the achievement therapy goals. Our study aimed evaluate QoL in vs. healthy volunteers, analyze likely influencing factors. From March 2021 through December 2021, we enrolled 140 consecutive adult subjects (100 40 controls). Overall, 95 with 37 controls were...
Sarcopenia is thought to be related an increased risk of non-alcoholic steatohepatitis and advanced liver fibrosis. Our cross-sectional single-center study was designed analyze the prevalence sarcopenia in patients with NAFLD possible influencing factors.A survey on presence sarcopenia, fatigue, anxiety, depression, along a quality-of-life (QoL) assessment, forwarded by email 189 outpatients. Demographics, anthropometric clinical data (laboratory test results abdomen complete ultrasound...
This study investigates the role of gut microbiota in cardiovascular diseases, with an additional focus on pro-atherogenic metabolites. We use advanced network analysis and machine learning techniques to identify key microbial features linked coronary artery disease (CAD) heart failure reduced ejection fraction (HFrEF). cross-sectional included 189 participants divided into three groups: (
Aim. To study the relationship of gut microbiota (GM) composition with clinical and paraclinical characteristics patients coronary artery disease (CAD) heart failure reduced ejection fraction (HFrEF). Material methods . The included 64 (men, 71,9%) CAD, 33 87,9%) HFrEF 38 63,2%) various cardiovascular risk factors (control group). GM was assessed using real-time polymerase chain reaction next- generation sequencing. identify correlations characteristics, Spearman rank correlation coefficient...
Despite advances in diagnosis and treatment, heart failure (HF) still remains one of the unsolved problems modern cardiology. The appearance progression HF is preceded by development maladaptive myocardial remodeling. In this regard, search for new molecules therapeutic action aimed at preventing remodeling undoubted interest. context, galaninergic system seems to be a promising target. To date, evidence has been accumulated that activation leads an increase cardiomyocyte protection early...
Aim . To study the level of neuro-regulatory peptide galanin in patients with coronary artery disease (CAD) and without heart failure reduced ejection fraction (HFrEF) comparison individuals cardiovascular (CVD) included control group. Material methods The 80 male patients as follows: 30 CAD HFrEF; 20 CVD (control group). groups were comparable age body mass index (BMI). Results median (Me) HFrEF was 67,5 years, while — 56,5 years. In group, 73,4% had New York Heart Association (NYHA)...
Hypertension (HTN) and osteoporosis are major age-related conditions, each of which causes significant morbidity mortality. To date, data have been accumulated on the relationship between hypertension, markers bone matrix formation resorption. This review article discusses hypertension reduced mineral density, as well previously unknown pathogenetic mechanisms underlying it.
This study aimed to describe sonographic features of rectus femoris muscle (RFM) in patients with metabolic dysfunction-associated fatty liver disease (MASLD) and their correlation body composition parameters strength. A total 67 MASLD underwent dual-energy X-ray absorptiometry (DEXA), bioimpedance analysis (BIA), strength measurement (grip [GS] chair stand test [CST]), ultrasound (US) investigation the RFM dominant thigh using a 4 18 MHz linear probe. exhibited increased echogenicity,...
Body composition (BC) affects the risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD) and hypertension (HTN). Currently, dual-energy X-ray absorptiometry (DEXA) is considered gold standard for assessing BC, even though it has some limitations, including immobility, ionizing radiation, patient weight restrictions. The aim study was to evaluate correlations BC parameters measured by bioelectrical impedance analysis (BIA) with those DEXA in patients MASLD HTN.
The steady increase in the prevalence of carbohydrate metabolism disorders worldwide, with vast majority type 2 diabetes (T2D), specifies need to improve disease prevention measures. A special niche preventive continuum is occupied by early disorders, treatment which makes a significant contribution T2D prevention. absence characteristic clinical performance, inadequate apprehensive attitude healthcare professionals contributes unnoticed development while progressive lead micro-,...
Aim . To study the relationship between abundance of genera in gut microbiota (GM) and levels serum biomarkers chronic systemic inflammation endotoxemia patients with HFpEF. Material methods. The composition GM among 42 HFpEF (men, 57,1%) was assessed by 16S rRNA sequencing. median age 67,0 years, interquartile range [64,0; 71,5] years. Correlation multivariate regression analysis (with adjustments for sex age) relationships relative intestinal bacteria concentrations including...