A5046588257- Gut microbiota and health
- Probiotics and Fermented Foods
- RNA and protein synthesis mechanisms
- Bacterial Genetics and Biotechnology
- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- Diet and metabolism studies
- DNA Repair Mechanisms
- Endoplasmic Reticulum Stress and Disease
- RNA Research and Splicing
- Dermatology and Skin Diseases
- Skin and Cellular Biology Research
- Clostridium difficile and Clostridium perfringens research
- Biochemical and Molecular Research
- Microtubule and mitosis dynamics
- Indigenous Studies and Ecology
- Toxin Mechanisms and Immunotoxins
- Plant Molecular Biology Research
- Protein Degradation and Inhibitors
- Liver Disease Diagnosis and Treatment
- Cardiac Health and Mental Health
- Metabolism and Genetic Disorders
- RNA Interference and Gene Delivery
- Health, psychology, and well-being
- Machine Learning in Bioinformatics
Prokhorov General Physics Institute
2023-2025
Lomonosov Moscow State University
2023-2025
Institute for Information Transmission Problems
2018-2025
Engelhardt Institute of Molecular Biology
2024
Federal Medical-Biological Agency
2022-2024
Center for Strategic Research
2024
Moscow State University
2023
Russian Academy of Sciences
2022
The gut microbiota plays an important role in maintaining human health, as well the development of various pathologies, indicated by a large amount research. One manifestations imbalance microbiome composition is appearance diseases or immune reactions, particular, atopic dermatitis (AD) and/or food allergies (FA). In this research, using 16S NGS sequencing, it was found that children with and can be characterized having higher inflammatory potential. Both groups exhibited abundance...
Super-enhancers (SEs) are regions of the genome that play a crucial regulatory role in gene expression by promoting large-scale transcriptional responses various cell types and tissues. Recent research suggests alterations super-enhancer activity can contribute to development progression disorders. The aim this is explore multifaceted roles super-enhancers regulation their significant implications for understanding treating complex diseases. Here, we study summarise classification...
The human gut microbiota (HGM) have an impact on host health and disease. Amino acids are building blocks of proteins peptides, also serving as precursors many essential metabolites including nucleotides, cofactors, etc. Many HGM community members unable to synthesize some amino (auxotrophs), while other possess complete biosynthetic pathways for these nutrients (prototrophs). Metabolite exchange between auxotrophs prototrophs affects microbial structure. Previous studies acid phenotypes...
The study discloses the application of transformer-based deep learning models for task super-enhancers prediction in human tumor cell lines with a specific focus on sequence-only features within studied entities super-enhancer and enhancer elements genome. proposed SE-prediction method included GENA-LM at handling long DNA sequences classification task, distinguishing from enhancers using H3K36me, H3K4me1, H3K4me3 H3K27ac landscape datasets HeLa, HEK293, H2171, Jurkat, K562, MM1S U87 lines....
Non-alcoholic fatty liver disease (NAFLD) is considered the most common chronic worldwide, affecting nearly 25% of global adult population. Increasing evidence suggests that functional and compositional changes in gut microbiota may contribute to development promote progression NAFLD. 16S rRNA gene next-generation sequencing widely used determine specific features NAFLD microbiome, but a complex system such as requires comprehensive approach. We three different approaches: MALDI-TOF-MS...
To continue progress in the treatment of cardiovascular disease, there is a need to improve overall understanding processes that contribute pathogenesis disease (CVD). Exploring role gut microbiota various heart diseases topic great interest since it not so easy find such reliable connections despite fact undoubtedly affect all body systems. The present study was conducted investigate composition patients with atherosclerotic (ASCVD) and failure syndromes reduced ejection fraction (HFrEF) HF...
Aim. To study the relationship of gut microbiota (GM) composition with clinical and paraclinical characteristics patients coronary artery disease (CAD) heart failure reduced ejection fraction (HFrEF). Material methods . The included 64 (men, 71,9%) CAD, 33 87,9%) HFrEF 38 63,2%) various cardiovascular risk factors (control group). GM was assessed using real-time polymerase chain reaction next- generation sequencing. identify correlations characteristics, Spearman rank correlation coefficient...
Background. Currently, it is known that the gut microbiota plays an important role in functioning of immune system, and a rebalancing bacterial community can arouse complex reactions lead to immune-mediated responses organism, particular, development atopic dermatitis (AD). Cytokines chemokines are regulators innate adaptive response represent most biomarkers system. It changes cytokine profiles hallmark many diseases, including atopy. However, remains unclear how imbalance disrupts function...
Background. In many studies over the past decade, scientists have made a connection between composition of gut microbiota and human health. A number publications shown that bacteria are involved in metabolic physiological processes organism. The microbiome is unique for each person formed under influence various factors associated with both individual characteristics body environment. Different regional make it necessary to adapt certain conditions, including temperature fluctuations. Living...