A5079464394- Biosensors and Analytical Detection
- Mycotoxins in Agriculture and Food
- Advanced Biosensing Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Characterization and Applications of Magnetic Nanoparticles
- Monoclonal and Polyclonal Antibodies Research
- Salivary Gland Tumors Diagnosis and Treatment
- Digital Imaging for Blood Diseases
- Cardiomyopathy and Myosin Studies
- RNA Research and Splicing
- Pharmacological Effects and Assays
- Dye analysis and toxicity
- Phytase and its Applications
- Nanofabrication and Lithography Techniques
- Advanced Nanomaterials in Catalysis
- Acute Myocardial Infarction Research
- Analytical chemistry methods development
- Advanced Proteomics Techniques and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Genomics and Chromatin Dynamics
- Wheat and Barley Genetics and Pathology
- Sulfur Compounds in Biology
- Bone Tissue Engineering Materials
- Machine Learning in Bioinformatics
- Cardiovascular Effects of Exercise
Prokhorov General Physics Institute
2022-2025
Moscow Engineering Physics Institute
2022-2024
The study discloses the application of transformer-based deep learning models for task super-enhancers prediction in human tumor cell lines with a specific focus on sequence-only features within studied entities super-enhancer and enhancer elements genome. proposed SE-prediction method included GENA-LM at handling long DNA sequences classification task, distinguishing from enhancers using H3K36me, H3K4me1, H3K4me3 H3K27ac landscape datasets HeLa, HEK293, H2171, Jurkat, K562, MM1S U87 lines....
Express and highly sensitive immunoassays for the quantitative registration of cardiac troponin I (cTnI) are in high demand early point-of-care differential diagnosis acute myocardial infarction. The selection antibodies that feature rapid tight binding with antigens is crucial immunoassay rate sensitivity. A method presented most promising clones advanced via simultaneous characterization interaction kinetics different monoclonal (mAb) using a direct label-free multiplex spectral...
In this study, we present a novel and ultrasensitive magnetic lateral flow immunoassay (LFIA) tailored for the precise detection of zearalenone, mycotoxin with significant implications human animal health. A versatile straightforward method creating non-covalent labels is proposed comprehensively compared covalent immobilization strategy. We employ particle quantification (MPQ) technique characterization their functionality, including measuring antibody sorption density on surface. Through...
A novel approach to developing lateral flow assays (LFAs) for the detection of CYFRA 21-1 (cytokeratin 19 fragment, a molecular biomarker epithelial-origin cancers) is proposed. Magnetic bioconjugates (MBCs) were employed in combination with advanced optical and magnetic tools optimize assay conditions. The integrates such techniques as label-free spectral-phase interferometry, colorimetric detection, ultrasensitive magnetometry using particle quantification (MPQ) technique. For first time...
Magnetic particles (MPs) based on superparamagnetic iron oxide nanocrystals are increasingly used in modern research for the development of express technologies high-precision determination concentration biomolecules. In this work, we developed a universal method using MPs as polyfunctional agents that perform several different functions one analysis topical issues biochemical and medical diagnostics, original technology ultrasensitive detection nonlinear magnetic nanomaterials. The was...
Currently, one of the most dangerous mycotoxin for humans and animals is ochratoxin A (OTA). Despite significant progress in modern approaches detection low molecular weight compounds, express methods on-site sensitive quantification OTA food are still to be developed. Conjugates with a carrier protein - bovine serum albumin were characterized terms kinetics their interaction monoclonal antibodies against OTA. Spectral interferometric used label-free characterization real-time mode. An...
The methods for fast selection of the antibodies that provide maximal performance assays are highly demanded. Here, a label-free optical method is presented screening against free thyroxine (fT4). features real-time monitoring changes in biolayer thickness on sensor chip caused by association and dissociation molecules. single-used commonly available microscope glass cover slip. Among others, benefits developed include controllable real time immobilization virtually any biotinylated...