T. A. Shpakova

ORCID: 0000-0003-1450-929X
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About
Contact & Profiles
Research Areas
  • T-cell and B-cell Immunology
  • Molecular Biology Techniques and Applications
  • SARS-CoV-2 and COVID-19 Research
  • vaccines and immunoinformatics approaches
  • Immunotherapy and Immune Responses
  • Bacillus and Francisella bacterial research
  • SARS-CoV-2 detection and testing
  • RNA modifications and cancer
  • Genomic variations and chromosomal abnormalities
  • Gut microbiota and health
  • Biosensors and Analytical Detection
  • Forensic and Genetic Research
  • Nutrition, Genetics, and Disease
  • Human Health and Disease
  • RNA Research and Splicing
  • Gene expression and cancer classification
  • Diabetes and associated disorders
  • Marine and coastal plant biology
  • Chromosomal and Genetic Variations
  • Health, psychology, and well-being
  • Genomics and Phylogenetic Studies
  • Monoclonal and Polyclonal Antibodies Research
  • Genetic Associations and Epidemiology
  • Marine and coastal ecosystems
  • Dermatology and Skin Diseases

Federal Medical-Biological Agency
2022-2024

State Research Institute of Highly Pure Biopreparations
2023

Sakhalin State University
2001

Russian Academy of Sciences
2001

Background. Currently, it is known that the gut microbiota plays an important role in functioning of immune system, and a rebalancing bacterial community can arouse complex reactions lead to immune-mediated responses organism, particular, development atopic dermatitis (AD). Cytokines chemokines are regulators innate adaptive response represent most biomarkers system. It changes cytokine profiles hallmark many diseases, including atopy. However, remains unclear how imbalance disrupts function...

10.3390/biomedicines12102351 article EN cc-by Biomedicines 2024-10-15

Методика оценки уровняIgG-антител к различным белкам SARS-CoV-2 с помощью мультиплексного иммунофлуоресцентного анализа 1 Федеральное государственное бюджетное учреждение «Центр стратегического планирования и управления медико-биологическими рисками здоровью» Федерального медико-биологического агентства, 119121, г.Москва, Российская Федерация 2 медико-биологическое агентство, 123182, Резюме Введение.Определение сероло гического статуса пациентов в отношении необходимо для клинического...

10.33029/0206-4952-2023-44-1-109-119 article RU Immunologiya 2023-01-01

Bronchial asthma (BA) is a disease that still lacks an exhaustive treatment protocol. In this regard, the global medical community pays special attention to genetic prerequisites for occurrence of disease. Therefore, search polymorphisms underlying bronchial has expanded considerably. As present study progressed, significant amount scientific literature was analyzed and 167 genes reported be associated with development were identified. A group participants (n = 7,303) who had voluntarily...

10.32607/actanaturae.11853 article EN cc-by Acta Naturae 2023-05-03

The paper is concerned with the seasonal development of asexual conceptacles Bossiella compressa Kloczc. in Sea Japan near southwestern coast Sakhalin. Variations are revealed terms sporulation which took place since mid-1980's till late 1990's. An assumption about relation these variations to succession microphytes this region advanced.

10.1615/interjalgae.v3.i3.20 article EN International Journal on Algae 2001-01-01

An important role in the pathogenesis of autoimmune diseases is assigned to genetic factors, such as genes major histocompatibility complex, tumor necrosis factor, interleukin-2 receptor alpha, CD40 surface antigen gene, etc. To date, a large amount data has been accumulated that certain HLA alleles increase risk developing number (type I diabetes, primary adrenal insufficiency, idiopathic hypoparathyroidism, Graves' disease, rheumatoid arthritis, systemic lupus erythematosus, celiac...

10.2139/ssrn.4113797 article EN SSRN Electronic Journal 2022-01-01

Since the first news about detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appeared, a large amount data on variability virus genome have accumulated. Most mutations entrenched in viral are aimed at improving mechanisms host cell penetration, altering degree binding to protein receptors, evading immune system, and suppressing antiviral response. Knowledge functional role will allow diagnostic methods, treatment, vaccine prophylaxis regimens, as well predicting...

10.1089/regen.2022.0021 article EN cc-by Re GEN Open 2022-01-01
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