A5069594189- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Reproductive Biology and Fertility
- Receptor Mechanisms and Signaling
- Protein Kinase Regulation and GTPase Signaling
- Immune cells in cancer
- Growth Hormone and Insulin-like Growth Factors
- Monoclonal and Polyclonal Antibodies Research
- NF-κB Signaling Pathways
- Reproductive System and Pregnancy
- Cancer Immunotherapy and Biomarkers
- Inflammasome and immune disorders
- Kruppel-like factors research
- PARP inhibition in cancer therapy
- Metabolism, Diabetes, and Cancer
- Liver physiology and pathology
- Signaling Pathways in Disease
- Cancer, Hypoxia, and Metabolism
- Liver Diseases and Immunity
- Osteoarthritis Treatment and Mechanisms
- Chemokine receptors and signaling
- Genetic Syndromes and Imprinting
- T-cell and B-cell Immunology
- RNA and protein synthesis mechanisms
Anhui Medical University
2016-2025
China Pharmaceutical University
2024
Ministry of Education of the People's Republic of China
2016-2024
Chinese PLA General Hospital
2022-2023
Nanjing Medical University
2017-2023
University of Tsukuba
2019-2023
Changzhou No.2 People's Hospital
2022-2023
Qilu Hospital of Shandong University
2016-2019
Guangdong Medical College
2018
University of Pittsburgh Medical Center
2012-2016
The complexity of the tumor immunoenvironment is underscored by emergence and discovery different subsets immune effectors regulatory cells. Tumor-induced polarization cell differentiation function makes this unique environment even more intricate variable. Dendritic cells (DCs) represent a special group that display phenotype activity at site exhibit differential pro-tumorigenic anti-tumorigenic functions. DCs play key role in inducing maintaining antitumor immunity, but their...
Rheumatoid arthritis (RA) is an autoimmune disease and mainly characterized by abnormal proliferation of fibroblast-like synoviocytes (FLS). The up-regulated cellular membrane expression G protein coupled receptor kinase 2 (GRK2) FLS plays a critical role in RA progression, the increase GRK2 translocation activity promotes dysfunctional prostaglandin E4 (EP4) signaling proliferation. Recently, although our group found that paeoniflorin-6ʹ-O-benzene sulfonate (CP-25), novel compound, could...
Protumorigenic activity of immune regulatory cells has been proven to play a major role in precluding immunosurveillance and limiting the efficacy anticancer therapies. Although several approaches have offered deplete myeloid‐derived suppressor (MDSC) T cells, there are no data on how control suppressive dendritic cell (DC) accumulation or function tumor environment. immunosuppressive DC cancer was implicated immature plasmacytoid DC, details conventional (cDC) develop properties remain less...
// Wei-dong Qin 1 , Guo-liang Liu 2 Juan Wang 3 Hao Jian-ning Zhang Fan Yang Ma Xin-ying Ji Chen Li and Ming-xiang 4 Department of Critical Care Medicine, Qilu Hospital Shandong University, Jinan, Shandong, China The Henan Provincial Key Engineering Laboratory Antibody Drugs, School Kaifeng, Henan, Cardiology, Second Cardiovascular Remodeling Function Research, Chinese Ministry Education Public Health, Correspondence to: Qin, email: Zhang, Keywords : diabetic cardiomyopathy, poly(ADP-ribose)...
Abstract Brown adipose tissue (BAT) is an attractive therapeutic target for treating obesity and metabolic diseases. Octacosanol the main component of policosanol, a mixture very long chain aliphatic alcohols obtained from plants. The current study aimed to investigate effect octacosanol policosanol on high-fat diet (HFD)-induced obesity. Mice were fed chow, or HFD, with without treatment four weeks. HFD-fed mice showed significantly higher body weight fat compared chow-fed mice. However,...
IL-8 produced by prostate cancer cells may be responsible for the androgen-independent growth of advanced cancers. Accumulating evidence from microarray analyses and animal genetic models highlights central involvement transcription factor early response-1 (EGR-1) in carcinoma progression. It is unknown, however, whether knockdown EGR-1 inhibits production IL-8-mediated tumor metastasis. Here we show that a specific shRNA-Egr1 inhibited gene human cell line DU145. Conversely, enforced...
Nerve endings are often identified within solid tumors, but their impact on the tumor growth and progression remains poorly understood. Emerging data suggests that central nervous system may affect cancer development spreading via hypothalamic-pituitary-adrenal axis autonomous system. However, role of afferent sensory neurons in is unclear, except some reports perineural invasion prostate pancreatic cancer-related pain syndrome. Here, we provide results primary testing concept interaction...
Articular cartilage (AC) regeneration has always been a difficult problem for clinicians. Anti-inflammatory (M2) macrophages have anti-inflammatory and tissue repair effects. Exosomes are reported to multiple complicated biological functions. It shown that M2 macrophages-derived exosomes (M2D-Exo) can influence the course of certain diseases, but their effect on defects not reported. The aim this study was verify whether M2D-Exo could enhance acellular extracellular matrix (ACECM) scaffolds....
Low shear stress (LSS) plays a critical role in the site predilection of atherosclerosis through activation cellular mechanosensors, such as platelet endothelial cell adhesion molecule 1 (PECAM-1). Poly(ADP-ribose) polymerase (PARP-1) is nuclear enzyme that regulates expression various inflammatory cytokines. The high mobility group box (HMGB1) can induce inflammation response by binding to toll-like receptor 4 (TLR4). In present study, we aimed investigate and mechanism HMGB1 LSS induced...
Abdominal aortic aneurysm (AAA) is a common vascular degenerative disease. PARP-1 (poly[ADP-ribose] polymerase 1) nuclear enzyme, which plays critical role in diseases. We hypothesized that inhibition might have protective effects on AAA. In vivo, Ang II (angiotensin II) was continuously infused by micropump for 28 days to induce AAA mice. vitro, endothelial cells and smooth muscle were stimulated 24 hours. infusion increased expression activity successfully induced formation partly with...
G protein-coupled receptor kinase 2 (GRK2), a type of cytosolic enzyme, transiently translocates to the plasma membrane upon receptors (GPCRs) activation, and it also binds extracellular signal-regulated (ERK) inhibit activation ERK. GRK2 deficiency in endothelial cells (ECs) leads increased pro-inflammatory signaling promotes recruitment leukocytes activated ECs. However, role regulating angiogenesis remains unclear. Here, we show that is novel regulatory molecule on migration tube...
Cervical cancer is the most common malignant disease responsible for deaths of a large number women in developing world. Although certain strains human papillomavirus (HPV) have been identified as cause this disease, events that lead to formation tumors are not fully clear. STAT3 major oncogenic transcription factor involved development and progression tumors. However, mechanisms result loss control over activity understood. Gene associated with Retinoid-Interferon-induced Mortality-19...