Medical students experience depression and anxiety at a higher rate than the general population or from other specialties. While there is growing literature on high prevalence of symptoms about potential risk factors to among medical students, paucity evidence focused associations with family function, social support coping styles in Chinese vocational medicine students. This study aims investigate assess correlation between depression/anxiety styles.A sample 2057 Chongqing Pharmaceutical...

Natural killer (NK) cells accumulate at the maternal–fetal interface in large numbers, but their exact roles successful pregnancy remain poorly defined. Here, we provide evidence that T H 17 and local inflammation can occur during natural allogenic pregnancies. We found decidual NK promote immune tolerance by dampening inflammatory via IFN-γ secreted CD56 bright CD27 + subset. This NK-cell–mediated regulatory response is lost patients who experience recurrent spontaneous abortions, which...

Summary The identification of developmental stages in natural killer (NK) cells, especially human NK has lagged for decades. We characterize four novel populations defined by CD11b and CD27, which can represent the distinct cells from different tissues. Nearly all peripheral blood are + CD27 − whereas cord have populations. Interestingly, we found large deciduas. also demonstrate that each population could be characterized unique functional phenotypic attributes. display an immature...

Abstract Background Hepatic fibrosis is a common pathologic stage in chronic liver disease development, which might ultimately lead to cirrhosis. Accumulating evidence suggests that adipose-derived stromal cells (ADSCs)-based therapies show excellent therapeutic potential injury owing its superior properties, including tissue repair ability and immunomodulation effect. However, cell-based therapy still limits several problems, such as engraftment efficiency immunoreaction, impede the...

Abstract Osteoarthritis (OA) is a degenerative joint disease involving cartilage. Exosomes derived from Mesenchymal stem cells (MSCs) therapy improves articular cartilage repair, but subcutaneous fat (SC) stromal exosomes (MSCs SC -Exos), especially engineering MSCs -Exos for drug delivery have been rarely reported in OA therapy. This objective of this study was to clarify the underlying mechanism on repair and OA. could ameliorate pathological severity degree via miR-199a-3p, novel...

Stem cell-based therapies have the potential to heal burn wounds, but thus far had limited success in clinical practice. This study aimed test and improve therapeutic effects of adipose-derived stem cells (ASCs) on wound healing a rat model. We also explored role ASCs first isolated autologous each Sprague-Dawley used this experiment expanded them vitro. Then, 2-cm2 was made dorsal skin using specialized heating iron. The treated rats received either one or three injections 2 × 106 green...

Endometrial cancer (EC), the second most common malignancy in female reproductive system, has garnered increasing attention for its genomic heterogeneity, but understanding of metabolic characteristics is still poor. We explored dysfunctions EC through a comprehensive multi-omics analysis (RNA-seq datasets from The Cancer Genome Atlas [TCGA], Cell Line Encyclopedia [CCLE], and GEO datasets; Clinical Proteomic Tumor Analysis Consortium [CPTAC] proteomics; CCLE metabolomics) to develop useful...

Abstract The objective of this study is to compare the efficacy and safety Brucea javanica (Yadanzi) oil soft capsules (YDZ capsules) with or without Capecitabine/S‐1 in maintenance therapy for advanced gastric cancer (GC). From January 2019 December 2021, 105 patients treated at Jiangsu Cancer Hospital were enrolled categorized into 3 treatment groups: Group A received YDZ capsules, B Capecitabine S‐1, C a combination S‐1. compared across these groups using Objective Response Rate (ORR)...

The present study describes a rare case of hyalinizing clear cell carcinoma (HCCC) the tongue root and provides an analysis review relevant literature to improve understanding its diagnosis treatment. Clinical imaging pathological data from patient with primary HCCC were summarized, previously published studies reviewed through search. common symptoms, treatment strategies prognoses reported in compared. A total 16 cases retrieved. Histologically, these had tumors characterized by cells...

Highlights•ERK phosphorylates ESRRB on Ser42 and Ser43•Unphosphorylated facilitates pluripotency maintenance•ESRRB phosphorylation promotes extraembryonic endoderm differentiation from ESCsSummaryMEK (mitogen-activated protein kinase) inhibitor is widely used for culturing pluripotent stem cells, while prolonged MEK inhibition compromises the developmental potential of mouse embryonic cells (ESCs), implying a dual role MEK/ERK (extracellular signal-regulated signaling in maintenance. To...

The Hippo pathway modulates the transcriptional activity of Yap to regulate differentiation inner cell mass (ICM) and trophectoderm (TE) in blastocysts. Yet how signaling is differentially regulated ICM TE cells poorly understood. Through an inhibitor/activator screen, we have identified Rho as a negative regulator cells, PKA positive cells. We further elucidated novel mechanism by which suppresses Hippo, distinct from prevailing view that inhibits through modulating cytoskeleton remodeling...

The human papillomavirus (HPV) oncoproteins E6 and E7 are risk factors that primarily responsible for the initiation progression of cervical cancer, they play a key role in immortalization transformation by reprogramming differentiating host epithelial cells. It is unclear how cells transform into tumor-initiating (TICs). Here, we observed germ stem cell protein Piwil2 expressed pre-cancerous malignant lesions cervix cancer lines with exception non-HPV-infected C33a line. Knockdown shRNA led...

Abstract There is accumulating evidence that astrocytes play an important role in synaptic formation, plasticity, and pruning. Dicer the fine-tuning of microRNA (miRNA) network are for maintaining normal functions central nervous system dysregulation miRNAs implicated neurological disorders. However, little known about homeostasis synapse as well its plasticity. By selectively deleting postnatal astrocytes, Dicer-deficient mice exhibited reactive astrogliosis deficits dendritic spine...

Natural killer (NK) cells play important roles in adoptive cellular immunotherapy against certain human cancers. This study aims to establish a new NK cell line and its role for cancer immunotherapy. Peripheral blood samples were collected from 54 patients the line. A line, termed as NKG, was established Chinese male patient with rapidly progressive non-Hodgkin's lymphoma. NKG showed LGL morphology phenotypically identified CD56(bright) CD16(-), CD27(-), CD3(-), αβTCR(-), γδTCR(-), CD4(-),...

Aberrant histone acetylation plays an essential role in the neoplastic process via epigenetic silencing of tumour suppressor genes (TSGs); therefore, inhibition deacetylases (HDAC) has become a promising target cancer therapeutics. To investigate correlation with clinicopathological features and TSG expression, we examined expression acetylated H3 (AcH3), RARβ2, E-cadherin, β-catenin by immunohistochemistry 65 cervical squamous cell carcinoma patients. The results revealed that absence AcH3...

Venous thromboembolism (VTE) is closely relevant to head and neck cancer (HNC) prognosis, but little data exist on the risk prediction of VTE in patients with HNC.To study factors regarding HNC construct a nomogram model for its prediction.A cross-sectional retrospective was implemented comparatively analyze 220 from January 2018 December 2021. The Lasso algorithm used optimize selection variables. A predicting HNC-associated established using multivariate logistic regression analysis....

Cervical cancer is the most common malignant disease responsible for deaths of a large number women in developing world. Although certain strains human papillomavirus (HPV) have been identified as cause this disease, events that lead to formation tumors are not fully clear. STAT3 major oncogenic transcription factor involved development and progression tumors. However, mechanisms result loss control over activity understood. Gene associated with Retinoid-Interferon-induced Mortality-19...

Radical surgery of primary vaginal carcinoma typically involves partial or complete resection the vagina, and young patients in particular can experience sexual dysfunction after surgery. Vaginoplasty is mandatory for this population, multiple reconstructive techniques have been reported. Here we attempted to determine whether peritoneum a feasible alternative sigmoid colon vaginoplasty performed during radical Between February 2005 July 2009, 12 underwent Federation International Gynecology...

Mesenchymal stem cells (MSCs) secrete a variety of cytokines and growth factors in addition to self-renewal multiple forms differentiation. Some these secreted bioactive could improve meiotic maturation vitro subsequent embryo developmental potential. The aim the present study was determine whether (IVM) mouse oocyte with or without cumulus be improved by contact conditioned medium (CM) MSCs as well efficiency CM support follicular ovarian organ mice cultured on soft agar. potential matured...

Mesenchymal stem cells (MSCs) are thought to have great potential in the therapy of acute liver injury. It is possible that these may be regulated by stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) signaling axis, which has been shown promote migration inflammation-associated diseases. However, effects SDF-1/CXCR4 axis on MSCs-transplantation-based treatment for injury and underlying mechanisms largely unknown. In this study, we sought determine whether would augment...