A5020079804- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Cardiac Imaging and Diagnostics
- Peptidase Inhibition and Analysis
- Renal Diseases and Glomerulopathies
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- T-cell and B-cell Immunology
- Cardiovascular Function and Risk Factors
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Wnt/β-catenin signaling in development and cancer
- Ovarian cancer diagnosis and treatment
- RNA Research and Splicing
- Neuroendocrine Tumor Research Advances
- Cancer Mechanisms and Therapy
Ningxia Medical University
2009-2025
Lanzhou University
2019-2024
Shandong Provincial Hospital
2015-2024
Shandong First Medical University
2019-2024
Sun Yat-sen University
2021-2024
Sun Yat-sen University Cancer Center
2021-2024
First Hospital of Lanzhou University
2024
Nanjing Medical University
2023-2024
Jiangsu Province Hospital
2023-2024
First Affiliated Hospital of Jiangxi Medical College
2024
Due to its molecular heterogeneity and infiltrative nature, glioblastoma multiforme (GBM) is notoriously resistant traditional experimental therapeutics. To overcome these hurdles, targeted agents have been combined with conventional therapy. We evaluated the preclinical potential of a novel, orally bioavailable PI3K/mTOR dual inhibitor (XL765) in vitro vivo studies. In serially passaged human GBM xenografts that are more genetically stable than cell lines culture were used for all...
Ligation of GITR (glucocorticoid-induced tumor necrosis factor (TNF) receptor-related gene, or TNFRSF18) by agonist antibody has recently entered into early phase clinical trials for the treatment advanced malignancies. Although ability modulation to induce regression is well-documented in preclinical studies, underlying mechanisms action, particularly its effects on CD4(+)foxp3(+) regulatory T cells (Treg), have not been fully elucidated. We previously demonstrated that ligation vivo DTA-1...
To retrospectively evaluate safety and effectiveness of CT-guided percutaneous microwave ablation (MWA) in 47 patients with medically inoperable stage I peripheral non-small cell lung cancer (NSCLC).From February 2008 to October 2012, NSCLC were treated MWA sessions. The clinical outcomes evaluated. Complications after also summarized.At a median follow-up period 30 months, the time first recurrence was 45.5 months. local control rates at 1, 3, 5 years 96%, 64%, 48%, respectively....
The purpose of the study is to retrospectively evaluate safety and efficacy microwave ablation (MWA) for treatment ground-glass opacity (GGO)-lung adenocarcinoma.From December 2013 June 2017, a total 51 patients (22 males 29 females, mean age 69.4 ± 10.1 years) were included in this study, with lung adenocarcinoma lesions showing GGO (mean long-axis diameter 18.7 6.05 mm). They received 52 sessions percutaneous computed tomography-guided (CT-guided) MWA. First, was histologically defined by...
Abstract Background Recent studies have shown that according to the expression levels of achaete-scute homolog 1 (ASCL1), neurogenic differentiation factor (NEUROD1), and POU class 2 homeobox 3 (POU2F3), small cell lung cancer (SCLC) can be divided into four subtypes: SCLC-A (ASCL1-dominant), SCLC-N (NEUROD1-dominant), SCLC-P (POU2F3-dominant), SCLC-I (triple negative or SCLC-inflamed). However, there are limited data on clinical characteristics prognosis molecular subtypes SCLC. Methods...
Abstract Thyroid cancer (TC) is the most frequent malignancy of endocrine system. Apatinib, as an anti-angiogenic agent, has been applied in therapy several cancers. However, function and mechanism Apatinib TC have not clearly elucidated. After processing with alone or combined PKM2 overexpression plasmids, cell proliferation, migration, invasion were analyzed by EdU staining, CCK-8, wound healing, Transwell. Meanwhile. HUVECs incubated conditioned medium prepared from culture medium, tube...
Caspase-3 is a vital executioner molecule during the apoptotic process. Numerous studies have revealed close association of caspase-3 expression and breast cancer. Nevertheless, prognostic value for patients with cancer remains uncertain. To thoroughly analyze effect on clinicopathological features survival cancer, we conducted this meta-analysis. With various search strategies, electronic databases were comprehensively searched. A total 3091 from 21 ultimately obtained. The analysis results...
The safety and effectiveness of repeated computed tomography-guided percutaneous microwave ablation (MWA) in the management local recurrence (LR) patients with medically inoperable Stage I nonsmall cell lung cancer (NSCLC) were retrospectively evaluated.From February 2008 to August 2014, 104 NSCLC received MWA. Patients LR given repeat clinical outcomes complications MWA for evaluated.At a median follow-up 47 months, occurred 24/104 (23.1%) within 12 ± 8 months after rates higher tumors> 3.5...
Abstract Purpose To establish and validate radiomics models for predicting the early efficacy (less than 3 months) of microwave ablation (MWA) in malignant lung tumors. Methods The study enrolled 130 tumor patients (72 training cohort, 32 testing 26 validation cohort) treated with MWA. Post-operation CT images were analyzed. evaluate therapeutic effect ablation, three constructed by least absolute shrinkage selection operator logistic regression: tumoral (T-RO), peritumoral (P-RO),...
The occurrence and development of colorectal cancer (CRC) is an incredibly long process that involves continuous changes in the tumor microenvironment. These constant may ultimately result genetic alterations metabolic processes some symbiotic bacteria as a way to adapt changing environment. Patients with CRC exhibit altered abundance Bacteroides fragilis (B. fragilis) indicated by several studies. To better understand genomic characteristics virulence spectrum B. strains tissues, were...
Abstract Inactivating mutations in Neurofibromin 1 (NF1), a RAS-GTPase, have been identified significant subset of melanomas, both concurrent with and exclusive oncogenic BRAF RAS mutations. However, FDA-approved therapies targeting the MAPK pathway largely inactive this molecular cohort. To address underlying biology, we first leveraged sequencing data from 1, 912 melanoma tumor/normal pairs generated as part MSK-IMPACT initiative TP53 most event common to NF1-inactivated melanoma,...