A5100654108- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- PI3K/AKT/mTOR signaling in cancer
- Cancer Mechanisms and Therapy
- Medical Research and Treatments
- Diabetes and associated disorders
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peptidase Inhibition and Analysis
- 14-3-3 protein interactions
- Cancer-related molecular mechanisms research
- Microbial Natural Products and Biosynthesis
- Colorectal Cancer Surgical Treatments
- Pancreatic function and diabetes
- Gastric Cancer Management and Outcomes
- Protein Tyrosine Phosphatases
- Salivary Gland Disorders and Functions
- Meromorphic and Entire Functions
- Phagocytosis and Immune Regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal and Anal Carcinomas
- Fibroblast Growth Factor Research
Shandong Provincial Hospital
2011-2024
Shandong First Medical University
2020-2024
University of South China
2011-2024
Huazhong University of Science and Technology
2016-2023
Anhui Polytechnic University
2023
Shaoxing People's Hospital
2023
Janssen (United States)
2018-2023
Lishui Central Hospital
2023
Qingdao University
2015-2022
Qingdao Municipal Hospital
2022
Total mesorectal excision with fluorouracil-based preoperative chemoradiotherapy and postoperative chemotherapy is a standard treatment of locally advanced rectal cancer. This study investigated the addition oxaliplatin without radiotherapy.In this multicenter, open-label, phase III trial, we randomly assigned (1:1:1) Chinese adults (age 18 to 75 years) stage II/III cancer three treatments: five 2-week cycles infusional fluorouracil (leucovorin 400 mg/m(2), 2.4 g/m(2) over 48 h) plus...
Daratumumab, a monoclonal antibody targeting CD38, has been approved for use with standard myeloma regimens. An evaluation of subcutaneous daratumumab combined bortezomib, lenalidomide, and dexamethasone (VRd) the treatment transplantation-eligible patients newly diagnosed multiple is needed. Download PDF Research Summary. In this phase 3 trial, we randomly assigned 709 to receive either VRd induction consolidation therapy lenalidomide maintenance (D-VRd group) or alone (VRd group). The...
Interleukin-8 (IL-8) plays a vital role in the invasion and metastasis of hepatocellular carcinoma (HCC), is closely associated with poor prognosis HCC patients. Integrin αvβ3, member integrin family, has been reported to be overexpressed cancer tissues mediate cells. However, relationship between IL-8 αvβ3 underlying mechanism remains unclear.The expression IL-8, αv β3 cells was detected by quantitative real-time PCR, Western blot immunohistochemistry. Transwell assay used detect...
Abstract Non-alcoholic fatty liver disease (NAFLD) leads to hepatocellular carcinoma (HCC). However, the underlying mechanism remains largely unclear. Here, we investigated role of tumor suppressor Zinc fingers and homeoboxes 2 (ZHX2) in progression NAFLD HCC. ZHX2 expression was significantly decreased tissues, especially with NAFLD–HCC. overexpression disturbed lipid homeostasis cultured HCC cells, inhibited deposition hepatocytes both vitro vivo. Moreover, uptake exogenous lipids through...
The role of cellular senescence induced by radiation in bone loss has attracted much attention. As one the common complications anticancer radiotherapy, irradiation-induced deterioration is and clinically significant, but pathological mechanism not been elucidated. This study was performed to explore senescence-associated secretory phenotype (SASP) induction marrow-derived mesenchymal stem cells (BMSCs) irradiation its osteogenic differentiation dysfunction. It observed that irradiated BMSCs...
Background: The pseudouridine synthases (PUSs) have been reported to be associated with cancers. However, their involvement in hepatocellular carcinoma (HCC) has not well documented. Here, we assess the roles of PUSs HCC. Methods: RNA sequencing data TCGA-LIHC and LIRI-JP were downloaded from Cancer Genome Atlas (TCGA) International Consortium (ICGC), respectively. GSE36376 gene expression microarray was Gene Expression Omnibus (GEO). Proteomics for an HBV-related HCC cohort obtained CPTAC...
Abstract Purpose To establish and validate radiomics models for predicting the early efficacy (less than 3 months) of microwave ablation (MWA) in malignant lung tumors. Methods The study enrolled 130 tumor patients (72 training cohort, 32 testing 26 validation cohort) treated with MWA. Post-operation CT images were analyzed. evaluate therapeutic effect ablation, three constructed by least absolute shrinkage selection operator logistic regression: tumoral (T-RO), peritumoral (P-RO),...
Beta-tropomyosin (β-tropomyosin, TPM2) has been found to be downregulated in colorectal cancer (CRC) previous studies. In this study, we aimed investigate the mechanisms and potential biological consequences of downregulation TPM2 cancer. expression was assessed by qRT-PCR immunostaining. The functions were cell lines either overexpressing or underexpressingTPM2. Aberrant DNA methylation promoter region is associated with suppression primary tissue samples. Treatment demethylation agent...
BACKGROUNDCarcinoembryonic antigen (CEA) is a commonly used biomarker in colorectal cancer.However, controversy exists regarding the insufficient prognostic value of preoperative serum CEA alone rectal cancer.Here, we combined and maximum tumor diameter to correct level, which may better reflect malignancy cancer. AIMTo assess impact CEA/tumor size METHODSWe retrospectively reviewed 696 stage I III cancer patients who underwent curative resection from 2007 2012.These were randomly divided...
Alterbrassinoids A-D (1-4), the first examples of fusicoccane-derived diterpenoid dimers furnished by forming an undescribed C-12-C-18' linkage, were isolated from modified cultures Alternaria brassicicola. Compounds 1 and 2 represent unprecedented heterodimers, whereas 3 4 homodimers, also features anhydride motif. Their structures assigned via spectroscopic methods, electronic circular dichroism calculations, single-crystal X-ray diffraction. Putative biosynthetic pathways a bioactivity...
BACKGROUND Hepatocellular carcinoma (HCC) is the sixth most common type of cancer and fourth leading cause cancer-related death worldwide. Sarcomatoid HCC, which contains poorly differentiated carcinomatous sarcomatous components, a rare histological subtype HCC that differs from conventional HCC. It highly aggressive has poor prognosis. Its clinicopathological characteristics, surgical outcomes underlying mechanisms its nature have not been fully elucidated. AIM To examine characteristics...
Five new diterpenoid glycosides, dongtingnoids A–E (1–5), two aglycones, F and G (6 7), known analogues, cotylenins E J (8 9), belonging to the fusicoccane family, were isolated from fungus Penicillium sp. DT10, which was derived wetland soil Dongting Lake. Their structures absolute configurations elucidated based on spectroscopic analyses, acid hydrolysis, ECD calculations, X-ray crystallography. Dongtingnoid C (3) is first 16-nor-fusicoccane glycoside reported proposed form by oxidative...
Although abnormal expression of eukaryotic initiation factor 6 (eIF6) has been found in several human solid tumors, the functions and underlying mechanisms eIF6 progression colorectal cancer (CRC) still needs further elucidation. In present study, large-scale gene analysis based on Oncomine The Cancer Genome Atlas (TCGA) database revealed significantly higher baseline than normal tissues. Furthermore, our Chinese cohort study that high was correlated with aggressive characteristics poor...
Five new drimane-type sesquiterpenoids, named proversilins A–E (1–5), were isolated from the endophytic fungus Aspergillus versicolor F210 bulbs of Lycoris radiata. Their structures and absolute configurations characterized by extensive spectroscopic analysis, including 1D 2D NMR HRESIMS data, comparison experimental calculated electronic circular dichroism X-ray crystallography. Proversilins B–E (2–5) represent first examples natural products featuring an N-acetyl-β-phenylalanine moiety....
We performed a two-stage molecular epidemiological study to explore DNA methylation profiles for potential biomarkers of esophageal squamous cell carcinoma (ESCC) in Chinese population. Infinium Methylation 450K BeadChip was used identify genes with differentially methylated CpG sites. Sixteen candidate were validated by sequencing 1160 sites their promoter regions using the Illumina MiSeq platform. When excluding negative changes, 10 (BNIP3, BRCA1, CCND1, CDKN2A, HTATIP2, ITGAV, NFKB1,...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and its prognosis still poor. Mesencephalic astrocyte-derived neurotrophic factor (MANF) plays a key role in endoplasmic reticulum stress. ER stress HCC carcinogenesis. To confirm clinical prognostic value MANF HCC, we investigated expression level as recorded databases, results were verified by experiment. Survival analysis was probed Kaplan–Meier method. Cox regression models used to ascertain tissue microarray. The...
The zinc-fingers and homeoboxes protein 1 (ZHX1) consists of 873 amino acid residues, is localized in the cell nucleus appears to act as a transcriptional repressor. Previous studies have shown that ZHX1 interacts with nuclear factor Y subunit α (NF-YA), DNA methyltransferases (DNMT) 3B ZHX2, all which are involved tumorigenesis. However, exact role tumorigenesis remains unknown. aim current study was construct recombinant eukaryotic expression plasmid containing human (hZHX1) gene...
The relationship between tumor size and survival in intrahepatic cholangiocarcinoma (ICC) is still controversial. This study aimed to evaluate the prognostic ability of for solitary ICC after resection explore optimal cut-off values different subgroups.Patients with who underwent liver from Surveillance, Epidemiology, End Results Program Shandong Provincial Hospital were retrospectively analyzed. Kaplan-Meier Cox regression analysis used assess size. log-rank test was determine values, a...
Cancer survivors after radiotherapy may suffer a variety of bone‑related adverse side effects, including radioactive osteoporosis and fractures. Localized irradiation is common treatment modality for malignancies. Recently, series reactions injuries called indirect effects (remote changes in bone when other parts the body are irradiated) have been reported on irradiated area tissue radiotherapy. To address this issue, we developed rat localized model. Rats were with single dose X-rays to...