A5110810128- RNA modifications and cancer
- RNA regulation and disease
- Maternal and fetal healthcare
- Cancer-related gene regulation
- Galectins and Cancer Biology
- ATP Synthase and ATPases Research
- Maternal and Perinatal Health Interventions
- Cancer Cells and Metastasis
- Signaling Pathways in Disease
- Cancer, Hypoxia, and Metabolism
- CRISPR and Genetic Engineering
- Peptidase Inhibition and Analysis
- PI3K/AKT/mTOR signaling in cancer
- Wnt/β-catenin signaling in development and cancer
- RNA Research and Splicing
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Pregnancy-related medical research
- Pluripotent Stem Cells Research
- Ectopic Pregnancy Diagnosis and Management
- Cancer-related Molecular Pathways
- Reproductive Biology and Fertility
- Helicobacter pylori-related gastroenterology studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
Traditional Chinese Medicine Hospital of Kunshan
2024
China Medical University
2013-2024
Huazhong University of Science and Technology
2017-2024
Tongji Hospital
2017-2024
Northwest Women's and Children's Hospital
2024
Wannan Medical College
2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2024
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
First People's Hospital of Yunnan Province
2024
Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform comprehensive molecular characterization of 19 core genes in 9,125 samples across 33 cancer types using multidimensional "omic" data from The Cancer Genome Atlas. We identify somatic drivers among and the related microRNA (miRNA) regulators, functional genomic approaches, experimentally characterize YAP TAZ mutation effects miR-590 miR-200a regulation for TAZ. pathway activity is best characterized by...
RNA editing, a widespread post-transcriptional mechanism, has emerged as new player in cancer biology. Recent studies have reported key roles for individual miRNA editing events, but comprehensive picture of human cancers remains largely unexplored. Here, we systematically characterized the profiles 8595 samples across 20 types from sequencing data The Cancer Genome Atlas and identified 19 adenosine-to-inosine (A-to-I) hotspots. We independently validated 15 them by perturbation experiments...
In addition to genomic mutations, RNA editing is another major mechanism creating sequence variations in proteins by introducing nucleotide changes mRNA sequences. Deregulated contributes different types of human diseases, including cancers. Here we report that peptides generated as a consequence are indeed naturally presented leukocyte antigen (HLA) molecules. We provide evidence effector CD8+ T cells specific for edited derived from cyclin I present tumours and attack tumour presenting...
Both miRNAs and A-to-I RNA editing, a widespread nucleotide modification mechanism, have recently emerged as key players in cancer pathophysiology. However, the functional impact of editing remains largely unexplored. Here, we focused on an ADAR2-catalyzed site within miR-379-5p seed region. This was under-edited tumors relative to normal tissues, with high level being correlated better patient survival times across types. We demonstrated that contrast wild-type miRNA, edited inhibited cell...
Glioblastoma (GBM) is identified to share common signal pathways between glioma and immune cells. Here, we find that T cell immunoglobulin domain mucin protein 3 (TIM-3) one of the most co-inhibitory checkpoints in GBM shared by tumor non-tumor Glioma cell-intrinsic TIM-3 involved not only regulating malignant behaviors cells but also inducing macrophage migration transition anti-inflammatory/pro-tumorigenic phenotype a TIM-3/interleukin 6 (IL6) signal. In mechanism, as major regulators IL6,...
Homo sapiens longevity assurance homolog 2 of yeast LAG1 (LASS2), also known as tumor metastasis suppressor gene 1 (TMSG1), was firstly cloned by our laboratory in 1999. However, its antitumor molecular mechanisms are still unclear. LASS2/TMSG-1 could directly interact with the C subunit Vacuolar H(+) ATPase (V-ATPase), which suggested that LASS2/TMSG1 might inhibit invasion and through regulating function V-ATPase. In this study, we explored effect small hairpin RNA (shRNA) targeting on...
// Pu Xia 1 , Xiao-Yan Xu 2 Department of Cell Biology, College Basic Medical Science, Liaoning University, Jinzhou, Liaoning, P.R. China Pathophysiology, Shenyang, Correspondence to: Xia, email: nn001007@163.com Keywords: CD44, The Cancer Genome Atlas, gastric cancer, colon bioinformatic analyses Received: May 06, 2016 Accepted: 29, Published: June 14, 2016 ABSTRACT CD44 is a well-recognized stem cell biomarker expressed in and cancer. In order to identify...
Long non-coding RNAs play critical roles in tumorigenesis and the immune process. In this study, RNA sequencing data for 946 glioma samples from The Cancer Genome Atlas Chinese Glioma databases were analyzed to evaluate prognostic value function of homeobox A transcript antisense myeloid-specific (HOTAIRM)1. HOTAIRM1 expression was associated with clinical molecular features glioma: patients high more likely be classified as malignant cases, elevated level shorter survival time subgroups...
Background: Interferon treatment, as an important approach of anti-tumor immunotherapy, has been implemented in multiple clinical trials glioma. However, only a small number gliomas benefit from it. Therefore, it is necessary to investigate the role interferons and establish robust biomarkers facilitate its application.Materials methods: This study reviewed 1,241 glioblastoma (GBM) 1,068 lower grade glioma (LGG) patients six cohorts. The transcription matrix information were analyzed using R...
Abstract Alteration in lipid composition is an important metabolic adaptation by cancer cells to support tumorigenesis and metastasis. Fatty acid 2-hydroxylase (FA2H) introduces a chiral hydroxyl group at the second carbon of fatty (FA) backbones influences structures signaling. However, underlying mechanisms through which FA 2-hydroxylation coupled tumor growth remain elusive. Here, we show that FA2H regulates specific reprogramming oncogenic signaling development colorectal cancer. highly...
Background ADAR1, the major enzyme for RNA editing, has emerged as a tumor-intrinsic key determinant cancer immunotherapy efficacy through modulating interferon-mediated innate immunity. However, role of ADAR1 in immune cells such macrophages remains unknown. Methods We first analyzed publicly accessible patient-derived single-cell RNA-sequencing and perturbed sequencing data to elucidate expression function macrophages. Subsequently, we evaluated combined effects conditional knockout...
Homo sapiens longevity assurance homologue 2 of yeast LAG1 (LASS2), also known as tumor metastasis suppressor gene 1 (TMSG1), is a newly found in 1999. Preliminary studies showed that it not only suppressed growth but closely related to metastasis, however, its molecular mechanisms still unclear. There have been reported protein encoded by LASS2/TMSG-1 could directly interact with the C subunit Vacuolar ATPase (V-ATPase), which suggested LASS2/TMSG1 might inhibit invasion and through...
Gastric cancer is one of the most common cancers in world. MAC30/Transmembrane protein 97 (TMEM97) aberrantly up-regulated many human carcinoma cells. However, function MAC30 gastric cells not studied.To investigate carcinoma, we used RNA silencing technology to knock down expression BGC-823 and AGS. Real-time quantitative PCR Western blot were analyze mRNA level related expression. The localization lamellipodia was observed by immunofluorescence. biological phenotypes examined cell...
Abstract Metabolism of polyamines is critical importance to physiological processes. Ornithine decarboxylase (ODC) antizyme inhibitors (AZINs) are capable interacting with antizymes (AZs), thereby releasing ODC from ODC-AZs complex, and promote polyamine biosynthesis. AZINs regulate reproduction, embryonic development, fibrogenesis tumorigenesis through other signaling pathways. Dysregulation has involved in multiple human diseases, especially malignant tumors. Adenosine-to-inosine (A-to-I)...