A5089413821- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- RNA modifications and cancer
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- interferon and immune responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Urinary Bladder and Prostate Research
- RNA Interference and Gene Delivery
- Signaling Pathways in Disease
- DNA Repair Mechanisms
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Entomopathogenic Microorganisms in Pest Control
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
China Medical University
2016-2025
Second Military Medical University
2011-2024
Changhai Hospital
2024
Wuyi University
2024
First Hospital of China Medical University
2015-2023
Nanjing University
2007-2023
Nanjing General Hospital of Nanjing Military Command
2007-2023
Henan University
2023
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2022-2023
Lanzhou University
2023
Abstract Purpose: Glioma tissues consist of not only glioma cells but also glioma-associated nontumor cells, such as stromal and immune cells. These dilute the purity play important roles in biology. Currently, implications variation are sufficiently clarified. Experimental Design: Here, tumor was inferred for 2,249 gliomas 29 normal brain from 5 cohorts. Based on transcriptomic profiling method, we classified CGGA TCGA-RNAseq cohorts RNAseq set discovery. Cases TCGA-microarray, REMBRANDT,...
Abstract Micro/nanorobots with active movement capabilities provide a new option for the treatment of glioblastoma (GBM). However, long working distance intravenous injection and protection blood‐brain barrier can prevent micro/nanorobots from reaching target location. Photodynamic therapy (PDT) has gradually appeared in GBM research. The limitation penetrating strength light source will nevertheless hinder application range PDT. Herein, magnetic continuum robot (MCR) to deliver optical...
Urothelial bladder cancer (UBC) is one of the most common lethal worldwide and 5-year survival rate has not improved significantly with current treatment protocols during last decade. Intravesical immunotherapy Bacillus Calmette-Guérin currently standard care for non-muscle invasive UBC. Recently, a subset patients locally advanced or metastatic UBC have responded to checkpoint blockade against programmed cell death 1 protein (PD-1) its ligand (PD-L1) cytotoxic T-lymphocyte antigen 4 that...
Transgenic technology has become an important technique for crop genetic improvement. The application of well-characterized promoters is essential developing a vector system efficient transformation. Therefore, isolation and functional validation more alternative constitutive to the CaMV35S promoter highly desirable.In this study, 2093-bp sequence upstream translation initiation codon ATG AtSCPL30 was isolated as full-length (PD1). To characterize (PD1) eight 5' deleted fragments (PD2-PD9)...
Abstract Endoplasmic reticulum (ER) stress has considerable impact on cell growth, proliferation, metastasis, invasion, angiogenesis and chemoradiotherapy resistance in various cancers. However, the effect of ER outcomes glioma patients remains unclear. In this study, we established an risk model based The Cancer Genome Atlas (TCGA) data set to reflect immune characteristics predict prognosis patients. Survival analysis indicated that there were significant differences overall survival (OS)...
Glioblastoma (GBM) is identified to share common signal pathways between glioma and immune cells. Here, we find that T cell immunoglobulin domain mucin protein 3 (TIM-3) one of the most co-inhibitory checkpoints in GBM shared by tumor non-tumor Glioma cell-intrinsic TIM-3 involved not only regulating malignant behaviors cells but also inducing macrophage migration transition anti-inflammatory/pro-tumorigenic phenotype a TIM-3/interleukin 6 (IL6) signal. In mechanism, as major regulators IL6,...
We previously demonstrated that the local immune status correlated with glioma prognosis. Interleukin-6 (IL6) was identified as an important immune-related risk marker related to unfavourable In this study, we further investigated role and regulation of IL6 signalling in glioma.The expression prognostic value receptor (IL6R) were explored The Cancer Genome Atlas (TCGA) REMBRANDT databases clinical samples. Functional effects genetic knockdown overexpression IL6R or stimulation examined vitro...
Abstract Soybean [Glycine max (L.) Merrill] is an important crop worldwide. In this study, a Chinese local soybean cultivar, Hedou 12, was resequenced by next generation sequencing technology to develop INsertion/DELetion (INDEL) markers for genetic mapping. 49,276 INDEL polymorphisms and 242,059 single nucleotide were detected between 12 the Williams 82 reference sequence. Of these, 243 candidate ranging from 5–50 bp in length chosen validation, 165 (68%) of them revealed 82. The validated...
Abstract The autosomal recessive genome instability disorder Ataxia–telangiectasia, caused by mutations in ATM kinase, is characterized the progressive loss of cerebellar neurons. We find that DNA damage associated with results dysfunctional behaviour human microglia, immune cells central nervous system. Microglial dysfunction mediated pro-inflammatory RELB/p52 non-canonical NF-κB transcriptional pathway and leads to excessive phagocytic clearance neuronal material. Activation ATM-deficient...
Background Previous epidemiological observational studies have reported an association between inflammatory bowel disease (IBD) and prostate cancer (PCa), but the causality is inconclusive. The purpose of this study was to evaluate IBD on PCa using mendelian randomization (MR) analysis. Methods We performed a two-sample MR analysis with public genome-wide (GWAS) data. Eligible instrumental variables (IVs) were selected according three assumptions inverse-variance weighted (IVW) method main...
Abstract Background Pituitary adenoma is one of the most common brain tumors. Most pituitary adenomas are benign and can be cured by surgery and/or medication. However, some show aggressive growth with a fast rate resistant to conventional treatments such as surgery, drug therapy, radiation therapy. These tumors, referred refractory adenomas, often relapse or regrow in early postoperative period. The tumor microenvironment (TME) has recently been identified an important factor affecting...
// Wen Cheng 1 , Xiufang Ren 2 Jinquan Cai 3 Chuanbao Zhang 4,5 Mingyang Li Kuanyu Wang 6 Yang Liu Sheng Han and Anhua Wu Department of Neurosurgery, The First Hospital China Medical University, Shenyang, Pathology, Shengjing Second Affiliated Harbin Harbin, 4 Beijing Neurosurgical Institute, Beijing, 5 Tiantan Hospital, Capital Dalian Dalian, Correspondence to: Wu, email: Keywords : glioblastoma, MGMT promoter methylation, miRNA, prognosis, predictive model Received May 02, 2015 Accepted...
Significance Genomic instability fuels tumor progression and treatment resistance in cancer. Causative factors means for clinical detection of genomic the bulk gliomas have been inadequately explored. We identify a conserved gene coexpression module centered on CDC20 (CDC20-M) glioma transcriptomes that encompasses broad activities cell proliferation genome maintenance. show high CDC20-M expression robustly predicts poor prognosis severe chromosomal mutation burden glioma. Core members...
Background: Glioblastoma (GBM) is the most lethal cancer of central nervous system. Integrin beta 5 (ITGB5) thought to be involved in intercellular signal transduction and regulation tumor initiation progression. However, function ITGB5 GBM not known. Methods: To address this question, we evaluated expression level clinical specimens by immunohistochemistry western blotting, as well association between patient survival using data from Chinese Glioma Genome Atlas The Cancer Atlas. biological...
Long non-coding RNAs play critical roles in tumorigenesis and the immune process. In this study, RNA sequencing data for 946 glioma samples from The Cancer Genome Atlas Chinese Glioma databases were analyzed to evaluate prognostic value function of homeobox A transcript antisense myeloid-specific (HOTAIRM)1. HOTAIRM1 expression was associated with clinical molecular features glioma: patients high more likely be classified as malignant cases, elevated level shorter survival time subgroups...
Background: Interferon treatment, as an important approach of anti-tumor immunotherapy, has been implemented in multiple clinical trials glioma. However, only a small number gliomas benefit from it. Therefore, it is necessary to investigate the role interferons and establish robust biomarkers facilitate its application.Materials methods: This study reviewed 1,241 glioblastoma (GBM) 1,068 lower grade glioma (LGG) patients six cohorts. The transcription matrix information were analyzed using R...
The tumor microenvironment (TME) plays a critical role in promoting the growth and metastasis of glioblastoma (GBM). Tumor-associated macrophages (TAMs), most abundant myeloid cells infiltrating TME, produce proinflammatory cytokines, regulate glioma cell pools, lead to GBM progression. Understanding mechanism GBM-TAMs regulation can help find new targeted therapeutic strategies against GBM. Based on CGGA TCGA cohorts, ARPC1B was defined as key macrophage-associated gene with prognostic...
Glioblastoma multiforme (GBM) with mesenchymal features exhibits enhanced chemotherapeutic resistance and results in reduced overall survival. Recent studies have suggested that there is a positive correlation between the GBM status immune cell infiltration. However, mechanisms by which acquires its tumor microenvironment-dependent manner remains unknown. Here, we uncovered chemerin-mediated autocrine paracrine network phenotype of cells strengthened. We identified chemerin as prognostic...
Glioblastoma (GBM) is the most common brain tumor and remains incurable. Primary GBM cultures are widely used tools for drug screening, but there a lack of genomic pharmacological characterization these primary cultures. Here, we collect 50 patient-derived glioma cell (PDGC) lines characterize them by whole genome sequencing, RNA response screening. We identify three molecular subtypes among PDGCs: mesenchymal (MES), proneural (PN), oxidative phosphorylation (OXPHOS). Drug profiling reveals...