A5032664272- Geotechnical Engineering and Underground Structures
- Geotechnical Engineering and Soil Stabilization
- Geotechnical Engineering and Analysis
- Geotechnical Engineering and Soil Mechanics
- Landslides and related hazards
- Soil and Unsaturated Flow
- Grouting, Rheology, and Soil Mechanics
- Dam Engineering and Safety
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Extraction and Separation Processes
- Advanced NMR Techniques and Applications
- Recycling and Waste Management Techniques
- Glioma Diagnosis and Treatment
- Zeolite Catalysis and Synthesis
- Tunneling and Rock Mechanics
- Cancer, Lipids, and Metabolism
- Vitamin D Research Studies
- Microplastics and Plastic Pollution
- Immune cells in cancer
- Underground infrastructure and sustainability
- Genetically Modified Organisms Research
- ATP Synthase and ATPases Research
- Analytical chemistry methods development
- Nanoplatforms for cancer theranostics
Chinese Institute for Brain Research
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Southwest Jiaotong University
2017-2024
South China University of Technology
2022-2024
Ministry of Transportation of Ontario
2023
Soochow University
2023
Shandong Academy of Sciences
2021
Qilu University of Technology
2021
University of Shanghai for Science and Technology
2020
China University of Mining and Technology
2018
Brown adipose tissue (BAT) has attracted considerable research interest because of its therapeutic potential to treat obesity and associated metabolic diseases. Augmentation brown fat mass and/or function may represent an attractive strategy enhance energy expenditure. Using high-throughput phenotypic screening induce adipocyte reprogramming in committed myoblasts, we identified a retinoid X receptor (RXR) agonist, bexarotene (Bex), that efficiently converted myoblasts into adipocyte-like...
Soil is a complex material that exhibits both spatial variability and anisotropy. For simplicity, the traditional approach for analyzing slope stability often assumes soil homogeneous or isotropic, which can lead to an overestimation of reliability. To address this issue, novel proposed in study uses anisotropic yield criterion based on random finite-element method evaluate influence strength anisotropy stability, while accounting The applied typical case reliability analysis. It shown...
Both mammals and adult humans possess classic brown adipocytes beige adipocytes, the amount activity of these are considered key factors in combating obesity its associated metabolic diseases. Uncoupling protein 1 (Ucp1) is functional marker both adipocytes. To facilitate a reliable, easy, sensitive measurement Ucp1 expression vivo vitro, we generated Ucp1-2A-luciferase knock-in mouse by deleting stop codon for gene replacing it with 2A peptide. This peptide was followed luciferase coding...
This paper presents a unified critical state parameter model for evaluating sand and overconsolidated clay, which is named as CASM-S. The formulated in terms of the modification clay model, i.e., CASM, by incorporating subloading surface theory with an overconsolidation R. Although standard CASM proves to be useful modelling sand, (1) requires rate ratio constant contrast observed behaviour soils (2) only allows elastic deformation develop at that may underestimate corresponding peak stress...
Glioblastoma (GBM) is the most common brain tumor and remains incurable. Primary GBM cultures are widely used tools for drug screening, but there a lack of genomic pharmacological characterization these primary cultures. Here, we collect 50 patient-derived glioma cell (PDGC) lines characterize them by whole genome sequencing, RNA response screening. We identify three molecular subtypes among PDGCs: mesenchymal (MES), proneural (PN), oxidative phosphorylation (OXPHOS). Drug profiling reveals...
Appropriate constitutive models and reliable excavation support sequences are believed to be the major concern in using finite element (FE) analysis simulate shield tunnel excavation. This paper presents systematic two-dimensional (2D) three-dimensional (3D) FE analyses employing a number of accounting for initial soil anisotropy non-coaxial plasticity, as evidenced within site investigations from Tsinghuayuan Tunnel Jing-Zhang high-speed railway China. The aim is assess effects both...
In this paper, we analyse the mitigation effects of open trenches on vibrations induced by subway trains. The study is performed using both physical model tests and numerical simulations. effectiveness evaluated calculating frequency response function (FRF) vibration acceleration peak (VAP) in time domains. experimental results demonstrate that trench has clear dynamic soil response. Both domain suggest soils beyond could be significantly affected, due to existence trench. According...
This paper presents a comparison of the performance explicit algorithm and semi-complete in numerical implementations an unconventional plastic model for soils. The new model, named CASM-S, is developed by incorporating sub-loading surface theory into standard unified clay sand (i.e., CASM), to enhance prediction ability mechanical behavior over-consolidated complete CASM-S based on sub-stepping method with technique automatic error control (SUBM), while adopts cutting-plane integration...
The unique case of<bold>COK-14</bold>existing in a relaxed interrupted and rigid connected state provides insight into the stability feasibility of zeolite frameworks.
Abstract This paper presents a modified unified critical state model to predict the mechanical responses of both clays and sands under over-consolidation cyclic loading conditions on basis clay sand (CASM), which is named as CASM-kII. Through application subloading surface concept, CASM-kII able describe plastic deformation inside yield reverse flow, thus expected capture behaviours soils. numerical implemented by using forward Euler scheme with automatic substepping error control. Then,...
ABSTRACTThis study develops a methodology for conducting quantitative seismic risk assessment shallow-buried tunnels that are induced by active fault dislocations. A case tunnel crossing strike-slip zone is performed using this method. The fault-tunnel angle, the bedrock overburden thickness, burial depth, lining and soil properties parameters analysed in terms of their effects on responses, fragility curves, risks tunnels. This could quantify existing metro pass through zones, also assist...
In this paper, a noncoaxial plane strain soil model is developed in the framework of initial strength anisotropy that described by taking internal friction angle to be function principal stress orientations. The conventional Mohr-Coulomb (M-C) yield criterion generalized give an anisotropic criterion, with curve deviatoric space forming ellipse. Both rotational and eccentric ellipses are discussed. formulation constitutive equations general form terms plastic rate. form, rate divided into...