A5100397159- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Immune Cell Function and Interaction
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Education
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Diet, Metabolism, and Disease
- MicroRNA in disease regulation
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Chronic Disease Management Strategies
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Fibroblast Growth Factor Research
- Mobile Health and mHealth Applications
- Reproductive tract infections research
- RNA modifications and cancer
Shanghai Ocean University
2025
Ministry of Agriculture and Rural Affairs
2025
Hunan University
2025
Chongqing Medical University
2012-2025
Central South University
2015-2024
Second Xiangya Hospital of Central South University
2015-2024
Integrated Chinese Medicine (China)
2024
Public Health Agency of Canada
2024
Tianjin Medical University
2023-2024
Creative Commons
2016-2024
Because of the rapid change in lifestyle China, there is concern that diabetes may become epidemic. We conducted a national study from June 2007 through May 2008 to estimate prevalence among Chinese adults.
OBJECTIVE— Fibroblast growth factor 21 (FGF21) is a metabolic regulator with multiple beneficial effects on glucose homeostasis and insulin sensitivity in animal models. This study aimed to investigate the relationship between its serum levels various cardiometabolic parameters humans. RESEARCH DESIGN AND METHODS— A newly developed immunoassay was used measure FGF21 232 Chinese subjects recruited from our previous cross-sectional studies. The mRNA expression of liver adipose tissues were...
Mitochondria play a crucial role in tubular injury diabetic kidney disease (DKD). MitoQ is mitochondria-targeted antioxidant that exerts protective effects mice, but the mechanism underlying these not clear. We demonstrated mitochondrial abnormalities, such as defective mitophagy, reactive oxygen species (ROS) overexpression and fragmentation, occurred cells of db/db accompanied by reduced PINK Parkin expression increased apoptosis. These changes were partially reversed following an...
The two major classes of antidiabetic drugs, sulfonylureas and metformin, may differentially affect macrovascular complications mortality in diabetic patients. We compared the long-term effects glipizide metformin on cardiovascular events type 2 patients who had a history coronary artery disease (CAD).This study is multicenter, randomized, double-blind, placebo-controlled clinical trial. A total 304 with CAD, mean age = 63.3 years (range, 36-80 years), were enrolled. Participants randomly...
The past 30 years have witnessed significant increases in the prevalence of type 2 diabetes mellitus (T2DM) China. A 1980 epidemiological survey that included 000 people from 14 provinces and cities nationwide indicated was 0.67% 1. 1994–1995 210 19 found 2.5% among individuals who were 25–64 old (with a population standardized rate 2.2%) impaired glucose tolerance 3.2% 2.1%) 2. national nutrition conducted 2002, showed prevalences 4.5% 1.8% over 18 urban rural areas, respectively 3. In...
<h3>Abstract</h3> <h3>Objective</h3> To estimate the incidence of type 1 diabetes in all age groups China during 2010-13. <h3>Design</h3> Population based, registry study using data from multiple independent sources. <h3>Setting</h3> National registration system 505 hospitals providing care, and communities patients with 13 areas across China, covering more than 133 million person years at risk, approximately 10% whole population. <h3>Participants</h3> 5018 people ages newly diagnosed...
Aims The present study aimed to assess the prevalence of hypertension among Chinese adults. Methods Data were obtained from sphygmomanometer measurements and a questionnaire administered 46239 adults ≥20 years age who participated in 2007–2008 China National Diabetes Metabolic Disorders Study. Hypertension was defined as blood pressure ≥140/90 mm Hg or use antihypertensive medication. Results A total 26.6% had hypertension, significantly greater number men hypertensive than women (29.2% vs...
Adult non-insulin requiring diabetes includes latent autoimmune of adults (LADA), distinguished from type 2 by the presence islet autoantibodies. LADA China determined characteristics Chinese LADA. This nationwide, multicenter, clinic-based cross-sectional study was conducted in 46 university-affiliated hospitals 25 cities. All 4,880 ketosis-free diabetic patients (<1 year postdiagnosis, without insulin therapy for >6 months, aged ≥30 years) had GAD antibody (GADA) and HLA-DQ genotype...
A substantial proportion of patients with adult-onset diabetes share features both type 1 (T1D) and 2 (T2D). These individuals, at diagnosis, clinically resemble T2D by not requiring insulin treatment, yet they have immunogenetic markers associated T1D. Such a slowly evolving form autoimmune diabetes, described as latent adults (LADA), accounts for 2–12% all though show considerable variability according to their demographics mode ascertainment. While therapeutic strategies aim metabolic...
Diabetes poses heavy social and economic burdens worldwide. management apps show great potential for diabetes self-management. However, the adoption of by patients is poor. The factors influencing patients' intention to use these are unclear. Understanding behavioral necessary support development promotion app use.This study aimed identify determinants based on an integrated theoretical model.The hypotheses our research model were developed extended Unified Theory Acceptance Use Technology...
The current epidemic status of diabetic retinopathy in China is unclear. A national prevalence survey complications was conducted. 50,564 participants with gradable non-mydriatic fundus photographs were enrolled. rates (95% confidence intervals) and vision-threatening 16.3% (15.3%-17.2%) 3.2% (2.9%-3.5%), significantly higher the northern than southern regions. differences between those who had not attained a given metabolic goal more pronounced for Hemoglobin A1c blood pressure low-density...
Because of rapid change in lifestyle risk factors, cardiovascular disease has become the leading cause death China. We sought to estimate national levels serum lipids and lipoproteins among Chinese adult population.We conducted a cross-sectional study nationally representative sample 46 239 adults aged ≥20 years. Fasting total, high-density lipoprotein, low-density lipoprotein cholesterol triglycerides were measured by standard methods. The age-standardized estimates 4.72 (95% confidence...
Adipocyte fatty acid-binding protein (A-FABP) has emerged as an important mediator of inflammation in macrophages. Macrophage-selective ablation A-FABP alone is sufficient to prevent the development high cholesterol diet-induced atherosclerosis apoE-deficient mice. However, precise mechanisms whereby modulates remain elusive. Here, we report that forms a finely tuned positive loop between JNK and activator protein-1 (AP-1) exacerbate lipopolysaccharide (LPS)-induced inflammatory responses...
Type 1 diabetes (T1D) is an autoimmune disease resulting from the self-destruction of insulin-producing β-cells. Reduced neutrophil counts have been observed in patients with T1D. However, pathological roles neutrophils development T1D remain unknown. Here we show that circulating protein levels and enzymatic activities elastase (NE) proteinase 3 (PR3), both which are serine proteases stored primary granules, were markedly elevated T1D, especially those duration less than year. Furthermore,...
Background We updated the prevalence of obesity and evaluated clinical utility separate combined waist circumference (WC) or body mass index (BMI) category increments in identifying cardiometabolic disorder (CMD) cardiovascular disease (CVD) risk Chinese adults. Methods Findings 46,024 participants aged ≥20 years, a nationally representative sample surveyed 2007–2008, were included this analysis. Taking cutoffs recommended by Joint Committee for Developing Guidelines (JCDCG) Working Group on...
The prevalence of type 2 diabetes mellitus (T2DM) is increasing rapidly among Chinese adults, and limited data are available on T2DM management the status glycemic control in China. We assessed efficacy oral antidiabetes drugs (OADs), glucagon-like peptide-1 (GLP-1) receptor agonists, insulin for treatment across multiple regions This was a multicenter, cross-sectional survey outpatients conducted 606 hospitals Data from all patients were collected between April June, 2011. A total 238,639...