A5100455748- Diabetes Treatment and Management
- Thyroid Cancer Diagnosis and Treatment
- Diabetes Management and Research
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Pancreatic function and diabetes
- Thyroid Disorders and Treatments
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adrenal and Paraganglionic Tumors
- Liver Disease Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- BRCA gene mutations in cancer
- Regulation of Appetite and Obesity
- Diet, Metabolism, and Disease
- Diabetic Foot Ulcer Assessment and Management
- Hormonal Regulation and Hypertension
- Bone health and treatments
- Radiomics and Machine Learning in Medical Imaging
- S100 Proteins and Annexins
- Diabetes Management and Education
- Meningioma and schwannoma management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Chronic Kidney Disease and Diabetes
Sun Yat-sen University
2025
The Seventh Affiliated Hospital of Sun Yat-sen University
2025
Breakthrough
2024
First Affiliated Hospital of Xinjiang Medical University
2023
Xinjiang Medical University
2023
Tianjin Medical University
2023
Guangxi Medical University
2012-2023
Shandong First Medical University
2023
Shandong Provincial QianFoShan Hospital
2023
University of Science and Technology of China
2020-2022
Emerging evidence indicates that patients with mental health conditions (MHCs) may receive less intensive medical care. Diabetes serves as a useful condition in which to test for MHC-related disparities We examined whether quality measures diabetes care are worse or without MHCs.This national, cross-sectional study included 313 586 noninstitutionalized Veterans Health Administration (identified from diagnostic codes and prescriptions) whose facility transmitted laboratory data central...
Objective To investigate the effects of endoscopic endonasal transphenoidal approach in treatment pituitary adenomas invading cavernous sinus (CS).Methods A retrospective analysis was performed 135 extending to CS treated via between April 2008 and 2013.The most common adenoma type non-functioning (NFPAs) (86 cases,63.7％),followed by PRL-secreting (28 cases,20.7％),growth hormone (GH)-secreting (18 cases,13.3％),ACTH-secreting (2 cases,1.5％),and TSH-secreting adenomas(1 cases,0.7％).The average...
Multifocality is often treated as a risk factor for papillary thyroid cancer (PTC), prompting aggressive treatments, but its prognostic value remains unestablished. To investigate the role of tumor multifocality in clinical outcomes PTC. Multicenter study relationship between and PTC 2638 patients (623 men 2015 women) with median [interquartile range (IQR)] age 46 (35 to 58) years (IQR) follow-up time 58 (26 107) months at 11 medical centers six countries. Surveillance, Epidemiology End...
Precise risk stratification-based treatment of solitary intrathyroidal papillary thyroid cancer (SI-PTC) that is larger than 1.0 cm and 4.0 or less undefined.
Abstract The genetic basis and corresponding clinical relevance of prolactinomas remain poorly understood. Here, we perform whole genome sequencing (WGS) on 21 patients with to detect somatic mutations then validate the digital polymerase chain reaction (PCR) analysis tissue samples from 227 prolactinomas. We identify same hotspot mutation in splicing factor 3 subunit B1 ( SF3B1 R625H ) 19.8% These mutant display higher prolactin (PRL) levels p = 0.02) shorter progression-free survival (PFS)...
How lymph node metastasis (LNM)-associated mortality risk is affected by BRAF V600E in papillary thyroid cancer (PTC) remains undefined.To study whether LNM-associated PTC.We retrospectively analyzed the effect of LNM on PTC-specific with respect to status 2638 patients (2015 females and 623 males) from 11 centers 6 countries, median age 46 [interquartile range (IQR) 35-58] years follow-up time 58 (IQR 26-107) months.Overall, showed a modest wild-type but strong one patients. In conventional...
Purpose To test whether the prognostic risk of male sex in papillary thyroid cancer (PTC) is determined by BRAF V600E and can thus be stratified status. Patients Methods We retrospectively investigated relationship between clinicopathologic outcomes PTC, particularly mortality, with respect to status 2,638 patients (male, n = 623; female, 2,015) from 11 centers six countries, median age 46 years (interquartile range, 35-58 years) at diagnosis follow-up time 58 months 26-107 months). Results...
Abstract Context Various risk factors have been associated with the of thyroid cancer in observational studies. However, causality is not clear given susceptibility confounding and reverse causation. Objective A 2-sample Mendelian randomization approach was used to estimate effect potential on risk. Methods Genetic instruments proxy 55 were identified by genome-wide association studies (GWAS). Associations these genetic variants estimated GWAS FinnGen Study (989 cases 217 803 controls)....
Mild subclinical hypothyroidism (SCH) affects a large number of people and is known to be risk factor for dyslipidemia. However, whether mild SCH patients should treated with L-thyroxine improve lipid profiles remains controversial. In addition, it also unclear all can benefit from treatment, regardless basal thyrotropin or levels. This study aimed assess the effects replacement therapy on patients.This open-label randomized controlled trial was performed in Ningyang County, Shandong...
Dopamine agonists (DAs) are the first-line treatment for prolactinomas, which account 25–30% of functioning pituitary adenomas, and bromocriptine (BRC) is only commercially available DAs in China. However, tumors resistant to therapy 5–18% patients. The exomes six responsive prolactinomas were analyzed by whole-exome sequencing. Using stringent variant calling filtering parameters, ten somatic variants that mainly associated with DNA repair or protein metabolic processes identified. New...
This study aims to investigate the association of body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) with chronic kidney disease (CKD). A cross-sectional survey was conducted in a nationally representative sample 123,629 Chinese urban adults who participated health examinations between 2008 2009. BMI, WC, WHtR were measured, as well serum urine biochemical tests. CKD defined an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 or protein positivity...
Importance Genetic and lifestyle factors are related to thyroid cancer (TC). Whether a healthy is associated with TC could attenuate the influence of genetic variants in remains equivocal. Objectives To examine associations between genetics incident whether adherence modifies association TC. Design, Setting, Participants A prospective cohort study using UK Biobank data recruited 502 505 participants aged 40 69 years March 13, 2006, October 1, 2010. total 307 803 European descent were at...
Pituitary adenomas exhibit a wide range of behaviors. The prediction invasion or malignant behavior in pituitary remains challenging. objective the present study was to identify genetic abnormalities associated with sporadic adenomas. In study, exomes six invasive (IPA) and non‑invasive (nIPA) were sequenced by whole‑exome sequencing. Variants confirmed dideoxynucleotide sequencing, candidate driver genes assessed an additional 28 A total 15 identified variants mainly angiogenesis,...
Lateral lymph node metastasis (LLNM) is a risk factor of poor prognosis in papillary thyroid cancer (PTC). We aimed to determine predictive factors and develop the nomograms for LLNM patients with microcarcinoma (PTMC) macro-PTC.We reviewed medical records 1,106 who underwent surgery between January 2019 2022. Patients were divided into PTMC macro-PTC group. developed preoperative postoperative predicting based on results multivariate analysis. Internal calibration was performed these...
Abstract Background Taq IB polymorphism in the cholesteryl ester transfer protein (CETP) gene has been reported to be associated with serum high-density lipoprotein cholesterol (HDL-C) levels and longevity several populations, but controversial results also arose probably due racial/ethnic diversity. Bama is a remote mountainous county located northwest of Guangxi, People's Republic China, which well known for its centuries. The current study was investigate possible association CETP lipid...