A5100758515- Gout, Hyperuricemia, Uric Acid
- Thyroid Cancer Diagnosis and Treatment
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Diabetes and associated disorders
- Thyroid Disorders and Treatments
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Inflammasome and immune disorders
- Alcohol Consumption and Health Effects
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Chronic Kidney Disease and Diabetes
- Peroxisome Proliferator-Activated Receptors
- MicroRNA in disease regulation
- Hormonal Regulation and Hypertension
- Diabetic Foot Ulcer Assessment and Management
- Blood Pressure and Hypertension Studies
- Circular RNAs in diseases
Qingdao University
2016-2025
Affiliated Hospital of Qingdao University
2016-2025
Xijing Hospital
2017-2024
Air Force Medical University
2017-2024
Jiaozuo University
2018-2024
Tianjin Medical University
2022-2024
Dalian Medical University
2022
Chongqing Medical University
2022
Second Affiliated Hospital of Chongqing Medical University
2022
Johns Hopkins University
2007-2018
Promoter mutations chr5:1,295,228C>T and chr5:1,295,250C>T (termed C228T C250T, respectively) in the gene for telomerase reverse transcriptase (TERT) have been reported various cancers need to be further investigated thyroid cancer.The aim of study was explore TERT promoter tumors examine their relationship with BRAF V600E mutation, iodine intake, clinicopathological behaviors cancer.TERT were identified by sequencing genomic DNA primary from normal- high-iodine regions China, correlation...
Individualized management, incorporating papillary thyroid cancer (PTC) variant-specific risk, is conceivably a useful treatment strategy for PTC, which awaits comprehensive data demonstrating differential risks of PTC variants to support.This study sought establish the clinicopathological risk major variants: conventional (CPTC), follicular-variant (FVPTC), and tall-cell (TCPTC).This was retrospective outcomes 6282 patients (4799 females 1483 males) from 26 centers The Cancer Genome Atlas...
Epidemiological studies have indicated that high iodine intake might be a risk factor for papillary thyroid cancer (PTC), which commonly harbors the oncogenic T1799A BRAF mutation.The objective of study was to investigate relationship between mutation in PTC and patients.We analyzed compared prevalences classical 1032 patients from five regions China uniquely harbor different contents natural drinking water, ranging normal (10-21 microg/liter) (104-287 microg/liter). The identified by direct...
Type 1 diabetes mellitus (T1DM) is an autoimmune disorder resulted from T cell-mediated destruction of pancreatic β-cells, how to regenerate β-cells and prevent the remnant neogenetic a tough problem. Immunomodulatory propertity mesenchymal stem cell make it illuminated overcome it. We assessed long-term effects implantation Wharton's jelly-derived cells (WJ-MSCs) umbilical cord for Newly-onset T1DM. Twenty-nine patients with newly onset T1DM were randomly divided into two groups, in group I...
Genetic alterations in the phosphatidylinositol-3-kinase (PI3K)/Akt pathway and their role thyroid tumor pathogenesis Chinese people remain undefined.The objective of study was to examine major genetic relationship PI3K/Akt differentiated tumors a cohort.We used real-time quantitative PCR for analysis PIK3CA copy gain direct DNA sequencing detection PIK3CA, RAS, PTEN mutations on genomic isolated from 234 tumors, including 31 follicular cancer (FTC), 141 papillary (PTC), 62 adenoma (FTA).We...
To investigate the effects of long-term effective control serum uric acid on renal function in patients with type 2 diabetes and asymptomatic hyperuricemia.Application randomized open parallel-controlled methods, a total 176 hyperuricemia were selected, was randomly divided into two groups for allopurinol or conventional treatments, respectively. Changes urinary albumin excretion rate (UAER), levels creatinine glomerular filtration (GFR) incidence new-onset diabetic nephropathy (DN)...
Multifocality is often treated as a risk factor for papillary thyroid cancer (PTC), prompting aggressive treatments, but its prognostic value remains unestablished. To investigate the role of tumor multifocality in clinical outcomes PTC. Multicenter study relationship between and PTC 2638 patients (623 men 2015 women) with median [interquartile range (IQR)] age 46 (35 to 58) years (IQR) follow-up time 58 (26 107) months at 11 medical centers six countries. Surveillance, Epidemiology End...
Cellular therapies offer novel opportunities for the treatment of type 2 diabetes mellitus (T2DM). The present study evaluated long-term efficacy and safety infusion Wharton's jelly-derived mesenchymal stem cells (WJ-MSC) on T2DM. A total 61 patients with T2DM were randomly divided into two groups basis basal therapy; in group I administered WJ-MSC intravenous twice, a four-week interval, II treated normal saline as control. During 36-month follow-up period, occurrence any adverse effects...
Objective The aim of this study was to investigate the long-term effective control serum uric acid by allopurinol on carotid intima-media thickness (IMT) in patients with type 2 diabetes (T2DM) and asymptomatic hyperuricemia (HUA). Methods This a randomized open parallel-controlled study. In study, 176 T2DM HUA were randomly allocated conventional or treatment groups basis computer-generated random number table. Changes IMT, biochemical indexes, high sensitive C-reactive protein (hs-CRP)...
The aim of this study was to determine the direct role liraglutide (LG) in adipogenesis and lipid metabolism.Lipid accumulation evaluated by oil red O staining, quantitative real-time PCR (qPCR) performed glucagon-like peptide 1 receptor (GLP-1R), fatty acid synthase (FASN) adipose triglyceride lipase (ATGL) expression 3T3-L1 preadipocytes, differentiated adipocytes tissues from mice. effects LG on metabolism were analyzed with qPCR, Western Blotting, immunohistochemistry (IHC)...