A5100630319- Growth Hormone and Insulin-like Growth Factors
- Nutrition and Health in Aging
- Lipid metabolism and disorders
- Genetics and Neurodevelopmental Disorders
- Nanoplatforms for cancer theranostics
- Genetic Syndromes and Imprinting
- Nanoparticle-Based Drug Delivery
- Insect and Arachnid Ecology and Behavior
- Neurobiology and Insect Physiology Research
- Genetic factors in colorectal cancer
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Animal Nutrition and Physiology
- Genomics and Rare Diseases
- Body Composition Measurement Techniques
- Pharmacology and Obesity Treatment
- Diet and metabolism studies
- Aeolian processes and effects
- Drug Transport and Resistance Mechanisms
- Cryospheric studies and observations
- Metal-Organic Frameworks: Synthesis and Applications
- Acupuncture Treatment Research Studies
- Climate change and permafrost
- Congenital Diaphragmatic Hernia Studies
- Click Chemistry and Applications
Affiliated Hospital of Jining Medical University
2016-2025
Ningbo Institute of Industrial Technology
2019-2024
Chinese Academy of Sciences
2019-2024
Uppsala University
2023-2024
Science for Life Laboratory
2023-2024
University of Chinese Academy of Sciences
2019-2024
Weifang University of Science and Technology
2024
National Observatory
2024
Northwest A&F University
2022-2023
Sichuan Agricultural University
2020-2022
Abstract Background Since the triglyceride glucose (TyG) index can reflect insulin resistance, it has been proven to be an efficient predictor of glycolipid-metabolism-related diseases. Therefore, this study aimed investigate predictive value TyG for visceral obesity (VO) and body fat distribution in patients with type 2 diabetes mellitus (T2DM). Methods Abdominal adipose tissue characteristics T2DM, including area (VAA), subcutaneous (SAA), VAA-to-SAA ratio (VSR), density (VAD), (SAD), were...
GH4099 is a typical age-hardened nickel-based superalloy with excellent overall performance, widely used in aerospace and other fields. In this study, novel tight-coupled dual-gas nozzle designed, two-phase coupling breakup model for the atomization process established based on volume of fluid flow model. The behavior melt under high-speed gas investigated depth. generation droplets analyzed, nozzle, enters chamber first impacted by intermediate airflow to generate initial droplets, move...
Recently, magnetic particle imaging (MPI) has shown diverse biomedical applications such as cell tracking, lung perfusion, image-guided hyperthermia, and so forth. However, the currently reported MPI agents cannot achieve possible theoretical detection limit of (20 nM). A previous study that performance superparamagnetic iron oxide nanoparticles (SPIONs) can be enhanced by carbon supporting metal doping. In current study, a series mixed metal–organic framework-derived SPIONs were synthesized...
Significant differences have been observed in the efficacy of recombinant human growth hormone (rhGH) treatment for short children. The present study aimed to identify genetic etiology stature and assess role molecular diagnosis predicting responses rhGH treatment. A total 407 children were included study, 226 whom received Whole-exome sequencing (WES) was conducted on underlying etiology. Correlations between examined. Pathogenic or likely pathogenic mutations identified 86 patients...
Zeolitic Imidazole Frameworks (ZIFs) are widely applied in nanomedicine for their high drug loading, suitable pore size, pH-responsive release, and so on. However, fast release during circulation, unexpected toxicity to mice major organs, undesirable long-term accumulation the lung even death currently hinder vivo biomedical applications. Herein, we report an amorphous ZIF-8 (aZIF-8) with loading of 5-Fu through pressure-induced amorphization. This nano-system avoids early circulation...
The signaling pathway of C-type natriuretic peptide (CNP) and its receptor (natriuretic 2, NPR2) is implicated in the process endochondral ossification, which crucial for linear growth long bones. Loss-of-function mutations NPR2 gene cause short stature. This study aimed to identify characterize truncating among Chinese families with Whole-exome sequencing Sanger were conducted potential mutations. Bioinformatic analysis was utilized assess pathogenicity two effects candidate mutation on...
Low testosterone levels is associated with higher cardiovascular risk in men diabetes. However, there are few studies on and the factors affecting them patients young-onset diabetes (YOD). The objective of this study was to investigate correlation between waist-to-hip ratio (WHR) diagnosed YOD. This cross-sectional involved 547 male type 2 mellitus (T2DM) from Endocrinology Department Affiliated Hospital Jining Medical University. participants were divided into two groups: a (YOD) group...
BACKGROUND Myosteatosis, rather than low muscle mass, is the primary etiologic factor of sarcopenia in patients with type 2 diabetes mellitus (T2DM). Myosteatosis may lead to a series metabolic dysfunctions, such as insulin resistance, systematic inflammation, and oxidative stress, all these dysfunctions are closely associated acceleration T2DM atherosclerosis. AIM To investigate association between myosteatosis coronary artery calcification (CAC) T2DM. METHODS Patients T2DM, who had not...
Since the ratio of creatinine to cystatin C (Cre/CysC) can reflect muscle volume, it has been proven be a predictor sarcopenia in patients with or without diabetes. Here, we investigated predictive value Cre/CysC for skeletal composition and its correlations glucose disposal ability diabetic complications type 2 diabetes.The index (SMI) mean attenuation (MMA) values 193 diabetes were obtained through analyses CT images at lumbar 3 level.Serum was significantly correlated both SMI (r=0.375,...
Multidrug resistance (MDR) is one of the main reasons for inefficiency cancer chemotherapy. As a consequence MDR, expression level membrane proteins might be changed, which can thus used to develop novel strategy its treatment. Based on high overexpression Y1 receptor (Y1R) protein and P-glycoprotein (P-gp) in multidrug resistant breast cell line, selective Y1R ligand [Asn6, Pro34]-NPY (AP) was employed stabilize chemotherapeutic drug doxorubicin (DOX) P-gp inhibitor tariquidar (Tar)...
Abstract Mythimna separata is a notorious phytophagous pest which poses serious threats to cereal crops owing the gluttony of larvae. Because short neuropeptide F (sNPF) and its receptor sNPFR are involved in diversity physiological functions, especially functions related feeding insects, it molecular target for control. Herein, an sNPF 2 s were identified cloned from M. . Bioinformatics analysis revealed that receptors had highly conserved RLRFamide C‐terminus 7 transmembrane domains,...
KBG syndrome is a rare autosomal dominant condition characterized by multisystem developmental disorder, primarily caused loss-of-function variants in ankyrin repeat domain-containing protein 11 (ANKRD11). Approximately 80 % of ANKRD11 associated with syndrome, are frameshift and nonsense variants. Current insight into the pathogenesis resulting from truncating remains limited. Here, we presented two members non-consanguineous Chinese pedigree both exhibiting characteristics fitting...
Abstract In this study, we investigate the spatial transport characteristics of cold-front-type sandstorms with different intensities in Hexi Corridor based on hourly observation data from 13 ground-based meteorological stations Corridor, upper and lower layers Meteorological Information Comprehensive Analysis And Process System, three-dimensional aerosol Vertical Feature Mask product obtained Cloud-Aerosol Lidar Orthogonal Polarization United States. The results show that influence range...