A5101882910- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Barrier Structure and Function Studies
- Traditional Chinese Medicine Analysis
- Intracerebral and Subarachnoid Hemorrhage Research
- Metabolomics and Mass Spectrometry Studies
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Pharmacological Effects of Natural Compounds
- Flavonoids in Medical Research
- Vagus Nerve Stimulation Research
- Traditional Chinese Medicine Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Neurological Disorders and Treatments
- Ginger and Zingiberaceae research
- Electric Vehicles and Infrastructure
- Alzheimer's disease research and treatments
- Axon Guidance and Neuronal Signaling
- Transportation and Mobility Innovations
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cerebrospinal fluid and hydrocephalus
- Phytochemistry and Biological Activities
- Immune Response and Inflammation
- Underground infrastructure and sustainability
Tianjin University of Traditional Chinese Medicine
2015-2025
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024-2025
Fuzhou University
2024
Tianjin haihe hospital
2023
Tianjin Economic-Technological Development Area
2017
Background Small molecules have been shown to modulate the neurogenesis processes. In search for new therapeutic drugs, herbs used in traditional medicines are promising candidates. Methodology and Principal Findings We selected a total of 45 natural compounds from Traditional Chinese herbal which extensively China treat stroke clinically, tested their proliferation-inducing activities on neural stem/progenitor cells (NSPCs). The screening results showed that salvianolic acid B (Sal B)...
Summary Background Recent studies revealed that baicalin, a flavonoid compound derived from the root of S cutellaria baicalensis G eorgi , could promote neuron differentiation NSPC s after commencing process in vitro . However, this may not be most efficacious strategy to determinate cell fate. Here, we have investigated whether baicalin can influence early events generation and stimulate adult neurogenesis. Results Transient exposure during proliferation activate M ash1 alter differential...
Recently, increasing attention has been paid to diabetic encephalopathy, which is a frequent complication and affects nearly 30% of diabetics. Because cognitive dysfunction from encephalopathy might develop into irreversible dementia, early diagnosis detection this disease great significance for its prevention treatment. This study investigate the specific metabolites biomarkers in urine prior onset (DCD) by using metabolomics technology. An ultra-high performance...
Stroke is a common central nervous system disease in clinical practice. patients often have infectious complications, such as pneumonia and infections of the urinary tract gastrointestinal tract. Although it has been shown that translocation host gut microbiota to lungs immune dysfunction plays vital role development infection after ischemic stroke, occurrence mechanism pulmonary at different time points hemorrhagic cerebral remain unclear. In this study, changes intestinal barrier function...
This study aims to explore the synergistic effects of main components in salvianolic acids for Injection(SAFI) on key pathological events cerebral ischemia, elucidating pharmacological characteristics SAFI neuroprotection. Two major gene modules related endothelial injury and neuroinflammation ischemia were mined from single-cell data. According topological distance calculated network medicine, potential component combinations screened out. The results showed that combination caffeic acid B...
Blood-brain barrier (BBB) disruption following ischemic stroke (IS) contributes to hemorrhagic transformation, brain edema, increased neural dysfunction, secondary injury, and mortality. The prevailing view attributes the destruction of tight junction proteins (TJs) resulting BBB damage IS. However, recent studies define a stepwise impairment transcellular followed by paracellular which accounts for leakage in endothelial transcytosis that has been proven be caveolae-mediated, preceding...
Right ventricular (RV) remodeling coupled with extensive apoptosis in response to unrestrained biomechanical stress may lead RV failure (RVF), which is the immediate cause of death majority patients pulmonary arterial hypertension (PAH). Overexpression β2‑adrenergic receptor (β2‑AR) signaling has been reported induce myocardiotoxicity left heart failure. However, role β2‑AR pathophysiology PAH development remained elusive. To address this issue, present study investigated changes...