A5028481015- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Pharmacological Effects of Natural Compounds
- Curcumin's Biomedical Applications
- Glycosylation and Glycoproteins Research
- Natural product bioactivities and synthesis
- Berberine and alkaloids research
- Hepatocellular Carcinoma Treatment and Prognosis
- Proteoglycans and glycosaminoglycans research
- Phagocytosis and Immune Regulation
- Cancer Research and Treatments
- Macrophage Migration Inhibitory Factor
- Cancer Cells and Metastasis
- Liver physiology and pathology
- Supramolecular Self-Assembly in Materials
- Advanced Drug Delivery Systems
- Ginseng Biological Effects and Applications
- Aquaculture Nutrition and Growth
- Cellular and Composite Structures
- Health and Wellbeing Research
- Synthesis and Characterization of Heterocyclic Compounds
- Lung Cancer Research Studies
- Dendrimers and Hyperbranched Polymers
- Sphingolipid Metabolism and Signaling
Weifang University of Science and Technology
2022-2025
Second Hospital of Shandong University
2025
Weifang Medical University
2016-2023
Bioscience (China)
2019-2023
Weifang University
2021
Shandong University
2016
Ocean University of China
2012
Recent research studies have shown that the low survival rate of liver cancer is due to drug resistance and metastasis. In tumor microenvironment (TME), activated hepatic stellate cells (aHSCs) been proven favor development cancer. Hence, combination therapy dual-targeting aHSCs might be an effective strategy for treatment this study, novel multifunctional liposomes (CAPS-CUR/GA&Gal-Lip) were prepared co-delivery curcumin (CUR) capsaicin (CAPS), in which glycyrrhetinic acid (GA) galactose...
Background: Tumor microenvironment (TME) plays a vital role in the development of hepatocellular carcinoma (HCC). Mounting evidence indicates that peripheral nerves could induce shift from quiescent hepatic stellate cells (HSCs) to cancer-associated fibroblasts (CAFs) by secreting substance P (SP). The anti-tumor strategy targeting "SP-HSCs-HCC" axis might be an effective therapy inhibit tumor growth and metastasis. Objective: In this study, we prepared novel liposomes (CUR-APR/HA&GA-LPs)...
Recent efforts have been focused on combining two or more therapeutic approaches with different mechanisms to enhance antitumor therapy. Moreover, nanosize drug-delivery systems for codelivering drugs proapoptotic and antiangiogenic activities exhibited great potential in efficient treatment of cancers.Glycyrrhetinic acid (GA)-modified liposomes (GA LPs) liver-targeted codelivery curcumin (Cur) combretastatin A4 phosphate (CA4P) were prepared characterized. In vitro cellular uptake,...
Combination therapy based on nano-sized drug delivery system has been developed as a promising strategy by combining two or more anti-tumor mechanisms. Here we prepared liver-targeted nanoparticles (GH-DPP) composed of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-polyetherimide (DSPE-PEG-PEI) with Glycyrrhetinic acid-modified hyaluronic acid (GA-HA) for co-delivery doxorubicin (DOX) and Bcl-2 siRNA. Particles size, zeta potential morphology were determined the...
Cancer-associated fibroblasts (CAFs) are a major component of the tumor microenvironment (TME). In hepatocellular carcinoma (HCC), quiescent hepatic stellate cells (HSCs) could be activated to become CAFs, which play critical role in progression and drug resistance. Therefore, recent efforts have been focused on combining anti-HSC pro-apoptotic activities improve anti-tumor efficacy drugs. this study, glycyrrhetinic acid hyaluronic acid–modified liposomes (GA-HA-Lip) were prepared for...
To investigate the mediating effect of social isolation on relationship between stigma and work ability in young middle-aged stroke patients. From May 2022 to 2024, a survey was conducted patients visiting neurology department tertiary hospital Weifang. The utilized General Information Questionnaire, Rankin Scale, Isolation Stigma Scale for Stroke Patients, Work Ability Scale. scores ability, isolation, among were 44.23 ± 12.72, 46.27 5.17, 43.37 4.48, respectively. There positive...
In recent years, the primary treatments for cancer have included chemotherapy, radiotherapy, and surgery. However, challenges such as poor prognosis, high recurrence rates, low survival diminished quality of life persist in management. Recently, immunotherapy has emerged a potent therapeutic approach treating tumors. To this end, we developed antibodies mucin 1 (MUC1) programmed cell death ligand (PD-L1) to functionalize liposomes incorporate doxorubicin (DOX) (DOX-aMUC1/aPDL1-Lip). This...
The tumor targetability and stimulus responsivity of drug delivery systems are crucial in cancer diagnosis treatment. In this study, hepatoma-targeting mixed micelles composed a hyaluronic acid–glycyrrhetinic acid conjugate acid-l-histidine (HA–GA/HA–His) were prepared through ultrasonic dispersion. formation characterization the confirmed via 1H-NMR, particle size, ζ potential measurements. vitro cellular uptake was evaluated using human liver carcinoma (HepG2) cells. antitumor effect...
Hepatocellular carcinoma (HCC), a common malignancy in China and globally, is primarily treated through surgical resection liver transplantation, with chemotherapy as significant synergistic option. Adenine (Ade), nucleobase, exhibits antitumor effects by blocking human hepatic cells S phase inhibiting tumor cell proliferation. However, its use limited owing to low solubility, poor targeting ability, nephrotoxicity. Therefore, liver-targeting drug delivery systems have attracted considerable...
Abstract: Small molecule-based nanodrugs with nanoparticles (NPs) that are mainly composed of small molecules, have been considered as a promising candidate for next-generation nanodrug, owing to their unique properties. Vorinostat (SAHA) is canonical US Food and Drug Administration-approved histone deacetylase (HDAC) inhibitor the treatment cutaneous T-cell lymphoma. However, lack efficacy against solid tumors hinders its progress in clinical use. Herein, novel nanodrug SAHA was developed...
The tumor-targeting ability and pH-sensitive properties of intelligent drug delivery systems are crucial for effective anti-tumor therapy.In this study, sHA-DOX/HA-GA mixed micelles were designed with the following properties: sulfated hyaluronic acid (sHA) was synthesized to block cell migration by inhibiting HAase; sHA-DOX conjugates via hydrazone bond realize DOX-sensitive release. introduction HA-GA conjugate could improve active-targeting cellular uptake.The results showed that...
The geometry of nanoparticles plays an important role in the process drug encapsulation and release. In this study, acid-responsive amphiphilic polypeptide consisting lysine leucine was prepared. neutral media, peptide L6K4 self-assembled to form spherical encapsulated fat-soluble antitumor drugs. intratumoral accumulation drug-loaded improved HeLa cells compared with normal cells. Compared a environment, increasingly acidic solutions changed secondary structure peptide. addition, expanded...
Activated platelets (PLT) could adhere to tumor cells promote progression and metastasis. Therefore, inhibiting platelet activation blocking the interaction between are an effective approach inhibit distal In this study, chondroitin sulfate (CS)–glycyrrhetinic acid (GA) dual ligand-modified liposomes (CS–GA–LIP) were prepared for codelivery of aspirin (ASP) curcumin (CUR). order simulate microenvironment, we established "HuH-7 + PLT" in vitro coculture cell model "H22 NIH/3T3" coinjected...
A novel GHH copolymer was synthesized using hyaluronic acid modified with glycyrrhetinic and L‑histidine (His), doxorubicin‑loaded nanoparticles (DOX/GHH) were prepared for liver‑targeted drug delivery pH‑responsive release. In the present study, characterized, their behaviors evaluated at different pH levels. The antitumor effect of DOX/GHH investigated in vitro vivo. Results showed that spherical, particle sizes ranged from 238.1 to 156.7 nm an increase degree substitution His. obviously...
Tumor angiogenesis plays a crucial role in tumor development, and recent efforts have been focused on combining proapoptotic antiangiogenic activities to enhance antitumor therapy.In this study, galactose-modified liposomes (Gal-LPs) were prepared for co-delivery of doxorubicin (DOX) combretastatin A4 phosphate (CA4P). The co-cultured system composed BEL-7402 human umbilical vein endothelial cells (HUVEC) was established effectively evaluate vitro anti-tumor activity through cell viability...
Abstract Recent efforts have focused on preparing drug‐loaded hydrogel for wound healing. In order to obtain an ideal dressing skin repair, a carboxymethyl chitosan‐gelatin was prepared co‐delivery of SP (substance P) and DMOG (dimethyloxallyl glycine) by chemical cross‐linking method using genipin as the agent. The synthesized hydrogels good biocompatibility physicochemical properties due low toxicity material. three‐dimensional network structure supports cell migration proliferation,...
IRI&398-s-LPs was destroyed in the TME, leading to rapid release of drugs, thus killing tumor cells and CAFs simultaneously. The combinational strategy by eliminating both “seeds” “soil” is beneficial for enhancing antitumor effect.
Background: Tumor angiogenesis has been proven to potentiate tumor growth and metastasis; therefore, the strategies targeting tumor-related have great potentials in antitumor therapy. Methods: Here, GA&Gal dual-ligand-modified liposomes co-loaded with curcumin combretastatin A-4 phosphate (CUCA/GA&Gal-Lip) were prepared characterized. A novel “BEL-7402+HUVEC” co-cultured cell model was established mimic microenvironment. The cytotoxicity migration assays performed against model. Angiogenesis...