A5102191382- Antimicrobial Peptides and Activities
- Wound Healing and Treatments
- Nanoparticle-Based Drug Delivery
- Glycosylation and Glycoproteins Research
- Pharmacological Effects of Natural Compounds
- Bacteriophages and microbial interactions
- Polydiacetylene-based materials and applications
- Supramolecular Self-Assembly in Materials
- Electrospun Nanofibers in Biomedical Applications
- Diabetic Foot Ulcer Assessment and Management
- Nanoplatforms for cancer theranostics
- Venomous Animal Envenomation and Studies
- RNA Interference and Gene Delivery
- Antimicrobial agents and applications
- Antibiotic Resistance in Bacteria
- Bone health and osteoporosis research
- Bone health and treatments
- Medical and Biological Ozone Research
- Enzyme Structure and Function
- Graphene and Nanomaterials Applications
- Boron Compounds in Chemistry
- Rabies epidemiology and control
- Sphingolipid Metabolism and Signaling
- Yersinia bacterium, plague, ectoparasites research
- Cell death mechanisms and regulation
Weifang Medical University
2014-2023
Shandong Academy of Pharmaceutical Sciences
2020
Weifang University
2020
Bioscience (China)
2018
Bioengineering Center
2018
Tianjin University of Science and Technology
2014
Tianjin University of Technology
2009
Background: Nonscar wound healing is a desirable treatment for cutaneous wounds worldwide. Peptide OH-CATH30 (OH30) from king cobra can selectively regulate the innate immunity and create an anti-inflammatory micro-environment which might benefit nonscar healing. Purpose: To overcome enzymatic digestion control release of OH30, OH30 encapsulated in carboxymethyl chitosan nanoparticles (CMCS-OH30 NP) were prepared their effects on evaluated. Methods: CMCS-OH30 NP by mild ionic gelation method...
We performed inverse synthesis to create 1152 structural analogs of polymyxin B with modified hydrophilicity and charge properties using OBOC technology. This led the identification two promising candidates that provided insights into structure-activity relationships. These compounds maintained high antibacterial activity while expanding safety window 4-16 times.
The tumor targetability and stimulus responsivity of drug delivery systems are crucial in cancer diagnosis treatment. In this study, hepatoma-targeting mixed micelles composed a hyaluronic acid–glycyrrhetinic acid conjugate acid-l-histidine (HA–GA/HA–His) were prepared through ultrasonic dispersion. formation characterization the confirmed via 1H-NMR, particle size, ζ potential measurements. vitro cellular uptake was evaluated using human liver carcinoma (HepG2) cells. antitumor effect...
In situ self-assembly in vivo can be used the enhanced diagnosis and therapy of major diseases such as cancer bacterial infections on basis an assembly/aggregation-induced-retention (AIR) effect. However, aggregation degree (αagg) is a significant parameter for determining delivery efficiency to lesions complex physiological environment real-time quantitative calculation still great challenge. Here, we developed magnetic resonance imaging (MRI) method sensitive αagg with detection limit 10-4...
Green tea polyphenol (GTP) is one of the most promising chemopreventive agent for cancer; it can inhibit cancer cell proliferation and induce apoptosis through p53-dependent signaling pathways. Unfortunately, many tumor cells lack functional p53, little known about effect GTP on p53-deficient/mutant cells. To understand p53-independent mechanisms in GTP-treated p53-dificient/mutant cells, we have now examined GTP-induced cytotoxicity human hepatoma Hep3B (p53-deficient). The results showed...
Hepatocellular carcinoma (HCC), a common malignancy in China and globally, is primarily treated through surgical resection liver transplantation, with chemotherapy as significant synergistic option. Adenine (Ade), nucleobase, exhibits antitumor effects by blocking human hepatic cells S phase inhibiting tumor cell proliferation. However, its use limited owing to low solubility, poor targeting ability, nephrotoxicity. Therefore, liver-targeting drug delivery systems have attracted considerable...
The extensive spread of multidrug resistance to Gram-negative bacteria has become a huge threat human health, where peptide-based antibacterial agents have emerged as powerful star weapon. Here we report lipopeptide (LP-20) constructed nanomicelle with different mechanism membrane curvature modulation, which induced dynamic fission resulting in acceleration and enhancement activity clinically isolated ESKAPE strains, including multidrug-resistant (MDR) pathogens. minimum inhibitory...
Background: The treatment of Staphylococcus aureus ( S. )-infected wounds is difficult. It causes extreme pain to tens thousands patients and increases the cost medical care. antimicrobial peptide OH-CATH30 (OH30) has a good killing activity against can play role in accelerating wound healing immune regulation. Therefore, it shows great potential for healing. Purpose: aim this study was overcome short half-life easy enzymolysis OH30 by using graphene oxide conjugated with polyethylene glycol...
Aerobic vaginitis (AV) is a gynecological disease associated with vaginal flora imbalance. The nonselective bactericidal nature of antibiotics and low customization rate probiotic supplementation in existing treatments lead to AV recurrence. Here, drug delivery strategy proposed that works the changing dynamics bacterial flora. In particular, core-shell nanogel (CSNG) designed encapsulate prebiotic inulin antimicrobial peptide Cath 30. allows for sequential release both drugs using...
Liver cancer is one of the most common malignancies worldwide and poses a serious threat to human health. The important treatment method, liver chemotherapy, limited due its high toxicity poor specificity. Targeted drug delivery systems have emerged as novel therapeutic strategies that deliver precise, substantial doses target sites via targeting vectors enhance efficacy. In present study, glycyrrhetinic acid‑modified hyaluronic acid (GA‑HA) was used carrier for model docetaxel (DTX) prepare...
Tumor-associated antigen mucin 1 (MUC1) is highly expressed in colorectal cancer and positively correlated with advanced stage at diagnosis poor patient outcomes. The combination of irinotecan capecitabine standard chemotherapy for metastatic known as XELIRI or CAPIRI, which significantly prolongs the progression-free survival overall patients compared to a single drug alone. We previously reported that peanut agglutinin (PNA)-conjugated liposomes showed enhanced delivery efficiency...
Diabetic foot ulcers (DFU) are severe complications of diabetes, posing significant health and societal challenges. Elevated levels reactive oxygen species (ROS) at the ulcer site hinder wound healing in most patients, while individuals with diabetes also more susceptible to bacterial infections. This study aims synthesize a comprehensive therapeutic material using polysaccharides from Pycnoporus sanguineus promote DFU healing, reduce ROS levels, minimize infections.Polysaccharides...