A5037325395- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Photodynamic Therapy Research Studies
- Advanced Photocatalysis Techniques
- Nanocluster Synthesis and Applications
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Phagocytosis and Immune Regulation
- Heavy metals in environment
- Nanoparticles: synthesis and applications
- Cancer Immunotherapy and Biomarkers
- Inflammatory Bowel Disease
- Molecular Sensors and Ion Detection
- Salivary Gland Disorders and Functions
- Biosensors and Analytical Detection
- Radiopharmaceutical Chemistry and Applications
- Cancer Research and Treatments
- Luminescence and Fluorescent Materials
- Heavy Metal Exposure and Toxicity
- Heavy Metals in Plants
- Mesenchymal stem cell research
South China University of Technology
2021-2025
Dalian University
2024-2025
Dalian University of Technology
2024-2025
University of Macau
2022-2025
Sichuan University
2015-2024
Quality Research
2023-2024
Suzhou Institute of Biomedical Engineering and Technology
2019-2023
Chinese Academy of Sciences
2017-2023
South China Botanical Garden
2022-2023
University of Chinese Academy of Sciences
2022-2023
Abstract Photodynamic therapy (PDT) is clinically promising in destructing primary tumors but ineffective against distant metastases. This study reports the use of immunogenic nanoparticles mediated combination PDT and magnetic hyperthermia to synergistically augment anti‐metastatic efficacy immunotherapy. Janus nanobullets integrating chlorine e6 (Ce6) loaded, disulfide‐bridged mesoporous organosilica bodies with heads (M‐MONs@Ce6) are tailored for redox/pH‐triggered photosensitizer release...
Chemotherapy causes off-target toxicity and is often ineffective against solid tumors. Targeted on-demand release of chemotherapeutics remains a challenge. Here, cancer-cell-membrane-coated mesoporous organosilica nanoparticles (MONs) containing X-ray- reactive oxygen species (ROS)-responsive diselenide bonds for controlled doxorubicin (DOX) at tumor sites are developed. DOX-loaded MONs coated with 4T1 breast cancer cell membranes (CM@MON@DOX) show greater accumulation prolonged blood...
A therapeutic strategy that targets multiple proinflammatory factors in inflammatory bowel disease (IBD) with minimal systemic side effects would be attractive. Here, we develop a drug-free, biodegradable nanomedicine acts against IBD by scavenging cell-free DNA (cfDNA) and reactive oxygen species (ROS). Polyethylenimine (PEI) was conjugated to antioxidative diselenide-bridged mesoporous organosilica nanoparticles (MONs) formulate (MON-PEI) exhibited high cfDNA binding affinity...
Microbiota-based therapeutics offer innovative strategies to treat inflammatory bowel diseases (IBDs). However, the poor clinical outcome so far and limited flexibility of bacterial approach call for improvement. Inspired by health benefits probiotics in alleviating symptoms diseases, bioartificial are designed restore intestinal microenvironment colitis regulating redox balance, immune responses, gut microbiome. The probiotic comprises two components: an E. coli Nissle 1917-derived membrane...
Enabling macrophages to phagocytose tumor cells holds great potential for cancer therapy but suffers from tremendous challenges because the upregulate antiphagocytosis molecules (such as CD47) on their surface. The blockade of CD47 alone is insufficient stimulate cell phagocytosis in solid tumors due lack "eat me" signals. Herein, a degradable mesoporous silica nanoparticle (MSN) reported simultaneously deliver anti-CD47 antibodies (aCD47) and doxorubicin (DOX) chemo-immunotherapy....
Combining radiotherapy with immune checkpoint blockade therapy offers a promising approach to treat glioblastoma multiforme (GBM), yet challenges such as limited effectiveness and immune-related adverse events (irAEs) persist. These issues are largely due the failure in targeting immunomodulators directly tumor microenvironment. To address this, biomimetic nanoplatform that combines genetically modified mesenchymal stem cell (MSC) membrane bioactive nanoparticle core for chemokine-directed...
Radiation dosage constraints and hypoxia-associated resistance lead to the failure of radiotherapy (RT), especially in hypoxic liver cancer. Therefore, intricate use combined strategies for potentiating complementing RT is important. In this work, we fabricated multifunctional Janus-structured gold triangle-mesoporous silica nanoparticles (NPs) as platforms deliver hypoxia-activated prodrug tirapazamine (TPZ) extrinsic radiosensitization, local photothermal therapy, hypoxia-specific...
Abstract Amplifying the chemotherapy‐driven immunogenic cell death (ICD) for efficient and safe cancer chemoimmunotherapy remains a challenge. Here, potential ICD nanoamplifier containing diselenide‐bridged mesoporous organosilica nanoparticles (MONs) chemotherapeutic ruthenium compound (KP1339) to achieve is tailored. KP1339‐loaded MONs show controlled drug release profiles via glutathione (GSH)‐responsive competitive coordination matrix degradation. High concentration of selectively evoked...
Designing a transformable nanosystem with improved tumor accumulation and penetration by tuning multiple physicochemical properties remains challenge. Here, near-infrared (NIR) light-driven size charge dual-transformation for deep is developed. Methods: The core-shell nanotransformer realized integrating diselenide-bridged mesoporous organosilica nanoparticles as reactive oxygen species (ROS)-responsive core an indocyanine green (ICG)-hybrid N-isopropyl acrylamide layer thermosensitive...
Senescent cancer cells are endowed with high immunogenic potential that has been leveraged to elicit antitumor immunity and potentially complement anticancer therapies. However, the efficacy of live senescent cell-based vaccination is limited by interference from immunosuppressive senescence-associated secretory phenotype pro-tumorigenic capacity cells. Here, a nanovaccine strong immunogenicity favorable for immunotherapy reported. The biomimetic integrating cell membrane-coated nanoadjuvant...
Fighting against intracellular bacteria that can evade antibiotics is a long-standing challenge. Inspired by the abundant production of hydrogen peroxide (H2O2) within phagosomes during phagocytosis bacteria, we have devised myeloperoxidase-like nanozyme capable facilitating phagosomal reactive oxygen species (ROS) environment, while simultaneously enabling delivery antibiotics. These novel nanozymes, denoted as GEN-NPs, has been fabricated through conjugation gentamicin (GEN) onto...
Abstract Exploration of medicines for efficient and safe management metabolic‐associated fatty liver disease (MAFLD) remains a challenge. Obeticholic acid (OCA), selective farnesoid X receptor agonist, has been reported to ameliorate injury inflammation in various diseases. However, its clinical application is mainly limited by poor solubility, low bioavailability, potential side effects. Herein hepatic‐targeted nanodrugs composed OCA cholesterol‐lowering atorvastatin (AHT) with an ideal...
Abstract Despite the promise of activatable chemotherapy, development a spatiotemporally controllable strategy for prodrug activation in deep tissues remains challenging. Herein, proof‐of‐concept is proposed gold nanocluster‐based that utilizes X‐ray irradiation to trigger liberation platinum (Pt)‐based conjugates, thus enabling radiotherapy‐directed chemotherapy. Mechanistically, irradiated prodrugs achieved through direct photoelectron transfer from excited‐state nanoclusters Pt(IV)...
Abstract Spinal cord injury (SCI) involves excessive inflammatory responses, which are characterized by the existence of high levels proinflammatory M1 macrophages rather than prohealing M2 macrophages, and oxidative stress. Interferon regulatory factor 5 (IRF5) is a promising therapeutic target in regulation macrophage reprogramming from to phenotype. However, knockdown IRF5 expression mediated small interfering RNA (siRNA) limited instability poor cellular uptake. In present study,...
Abstract The establishment of effective antitumor immune responses vaccines is mainly limited by insufficient priming tumor infiltration T cells and immunosuppressive microenvironment (TME). Targeting β‐adrenergic receptor (β‐AR) signaling exerts promising benefits on reversing the suppressive effects directly cells, but it appears to have considerably performance when combined with vaccine‐based immunotherapies. Herein, a membrane‐coated nanoplatform for codelivery adjuvant CpG propranolol...
Conventional oligonucleotide based drug delivery systems suffer from lengthy synthetic protocols, high cost, and poor chemical or enzymatic stability under certain circumstances. Canonical free individual nucleosides cannot form stable nanostructures in aqueous solution as vehicles. Here, we report the development of a monomeric self-assembled nucleoside nanoparticle (SNNP) into an efficient system which has currently no parallel such field. This was achieved using l-configurational...
Metal/silica nanoparticles (NPs) have long been used as antibacterial substitutes; however, fabrication of a degradable carrier for achieving sustained release profile, high bactericidal efficacy, and good biocompatibility is still challenge. Herein, we fabricated nanosilver-decorated biodegradable mesoporous organosilica (MONs) using biocompatible natural polyphenol, tannic acid (TA), not only nonsurfactant template to form MONs but also reducible agent generate nanosilvers. Such...
A near-infrared light-responsive hybrid hydrogel was injected in the tumor site. IR820 could not only produce local heat for photothermal therapy, but also generate singlet oxygen to induce degradation of MSNs controllable drug release.
Abstract Photothermal therapy (PTT) has been regarded as a promising strategy considering its advantages of high inherent specificity and lower invasive burden. Since the photothermal killing cells/bacteria showed different patterns death depending on varying temperature in PTT, change PTT is vital to cell/tissue response scientific research clinical application. On one hand, mild received substantial attention treatment cancer soft/hard tissue repair. other induced by capable antibacterial...