A5086467986- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Platelet Disorders and Treatments
- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Blood Coagulation and Thrombosis Mechanisms
- Protease and Inhibitor Mechanisms
- Lipid Membrane Structure and Behavior
- Lymphatic System and Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Periodontal Regeneration and Treatments
- Animal Virus Infections Studies
- Mesenchymal stem cell research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer Cells and Metastasis
- Bone health and treatments
- RNA Research and Splicing
- Angiogenesis and VEGF in Cancer
- Dendrimers and Hyperbranched Polymers
- Immune Response and Inflammation
- Advanced Nanomaterials in Catalysis
- Photonic and Optical Devices
- Phagocytosis and Immune Regulation
University of Pennsylvania
2024-2025
California University of Pennsylvania
2025
National Center for Nanoscience and Technology
2018-2024
Osaka University
2024
University of Chinese Academy of Sciences
2018-2023
Chinese Academy of Sciences
2023
First Affiliated Hospital of Bengbu Medical College
2021
Photodynamic therapy (PDT) is a promising anticancer treatment and clinically approved for different types of tumors. However, current PDT suffers several obstacles, including its neutralization by excess glutathione (GSH) in the tumor tissue strongly proangiogenic response. In this work, biomimic, multifunctional nanoparticle-based agent, combining tumor-targeted photosensitizer with GSH scavenging antiangiogenesis therapy, developed. A porphyrinic Zr-metal-organic framework nanoparticle...
Natural, extracellular membrane vesicles secreted by Gram-negative bacteria, outer (OMVs), contain numerous pathogen-associated molecular patterns which can activate systemic immune responses. Previous studies have shown that OMVs induce strong IFN-γ- and T cell-mediated anti-tumor effects in mice. However, IFN-γ is known to upregulate immunosuppressive factors the tumor microenvironment, especially checkpoint programmed death 1 ligand (PD-L1), may hamper cell function limit...
Biomimetic camouflage, i.e., using natural cell membranes for drug delivery, has demonstrated advantages over synthetic materials in both pharmacokinetics and biocompatibility, so represents a promising solution the development of safe nanomedicine. However, only limited efforts have been dedicated to engineering such camouflage endow it with optimized or additional properties, particular properties critical "smart" delivery system, as stimuli-responsive release. A pH-responsive biomimetic...
Rapid cut-off of blood supply in diseases involving thrombosis is a major cause morbidity and mortality worldwide. However, the current thrombolysis strategies offer limited results due to therapeutics' short half-lives, low targeting ability, unexpected bleeding complications. Inspired by innate roles platelets hemostasis pathological thrombus, platelet membrane-camouflaged polymeric nanoparticles (nanoplatelets) are developed for delivery thrombolytic drug, recombinant tissue plasminogen...
Excess iron deposition in the brain often causes oxidative stress-related damage and necrosis of dopaminergic neurons substantia nigra has been reported to be one major vulnerability factors Parkinson's disease (PD). Iron chelation therapy using deferoxamine (DFO) may inhibit this nigrostriatal degeneration prevent progress PD. However, DFO shows very short half-life vivo hardly penetrates blood barrier (BBB). Hence, it is great interest develop formulations for safe efficient intracerebral...
Compared with traditional chemotherapeutics, vascular disruption agents (VDAs) have the advantages of rapidly blocking supply nutrients and starving tumors to death. Although VDAs are effective under certain scenarios, this treatment triggers angiogenesis in later stage therapy that frequently leads tumor recurrence failure. Additionally, nonspecific targeting considerable side effects also impede clinical applications VDAs. Here we develop a customized strategy combines VDA an...
Microbiota-based therapeutics offer innovative strategies to treat inflammatory bowel diseases (IBDs). However, the poor clinical outcome so far and limited flexibility of bacterial approach call for improvement. Inspired by health benefits probiotics in alleviating symptoms diseases, bioartificial are designed restore intestinal microenvironment colitis regulating redox balance, immune responses, gut microbiome. The probiotic comprises two components: an E. coli Nissle 1917-derived membrane...
Abstract Lipid nanoparticles for delivering mRNA therapeutics hold immense promise the treatment of a wide range lung-associated diseases. However, lack effective methodologies capable identifying pulmonary delivery profile chemically distinct lipid libraries poses significant obstacle to advancement therapeutics. Here we report implementation barcoded high-throughput screening system as means identify lung-targeting efficacy cationic, degradable lipid-like materials. We combinatorially...
Abstract The ionizable lipidoid is a key component of lipid nanoparticles (LNPs). Degradable lipidoids containing extended alkyl branches have received tremendous attention, yet their optimization and investigation are underappreciated. Here, we devise an in situ construction method for the combinatorial synthesis degradable branched (DB) lipidoids. We find that appending branch tails to inefficacious via linkers boosts mRNA delivery efficiency up three orders magnitude. Combinatorial...
RNA-based therapeutics have gained traction for the prevention and treatment of a variety diseases. However, their fragility immunogenicity necessitate drug carrier. Lipid nanoparticles (LNPs) emerged as predominant delivery vehicle RNA therapeutics. An important component LNPs is ionizable lipid (IL), which protonated in acidic environment endosome, prompting cargo release into cytosol. Currently, there growing evidence that structure IL tails significantly impacts efficacy LNP-mediated...
Lipid nanoparticles (LNPs) have emerged as pivotal vehicles for messenger RNA (mRNA) delivery to hepatocytes upon systemic administration and antigen-presenting cells following intramuscular injection. However, achieving mRNA non-hepatocytes remains challenging without the incorporation of targeting ligands such antibodies, peptides, or small molecules. Inspired by comb-like polymeric architecture, here we utilized a multiarm-assisted design construct library 270 dendron-like degradable...
Metastasis remains the major cause of death in cancer patients. Thus, there is a need to sensitively detect tumor metastasis, especially ultrasmall for early diagnosis and precise treatment cancer. Herein, an ultrasensitive T1 -weighted magnetic resonance imaging (MRI) contrast agent, UMFNP-CREKA reported. By conjugating manganese ferrite nanoparticles (UMFNPs) with tumor-targeting penta-peptide CREKA (Cys-Arg-Glu-Lys-Ala), breast metastases are accurately detected. With behavior similar...
Periodontitis is a chronic inflammatory disease caused by the interaction of oral microorganisms with host immune response. Porphyromonas gingivalis (P.g.) acts as key mediator in subverting homeostasis local system. On one hand, P.g. inhibits phagocytosis and killing capacity cells. other increases selective cytokine release, which beneficial to its further proliferation. Here, we prepared penetrating macrophage-based nanoformulation (MZ@PNM)-encapsulating hydrogel (MZ@PNM@GCP) that...
Macrophages are integral components of the innate immune system, playing a dual role in host defense during infection and pathophysiological states. contribute to responses aid combatting various infections, yet their production abundant proinflammatory cytokines can lead uncontrolled inflammation worsened tissue damage. Therefore, reducing macrophage-derived cytokine release represents promising approach for treating acute chronic inflammatory disorders. However, limited macrophage-specific...
The inadequate tumor accumulation of anti-cancer agents is a major shortcoming current therapeutic drugs and remains an even more significant concern in the clinical prospects for nanomedicines. Various strategies aiming at regulating intratumoral permeability have been explored preclinical studies, with primary focus on vascular regulation stromal reduction. However, these methods may trigger or facilitate metastasis as tradeoff. Therefore, there urgent need innovative that boost drug...
During long-term antiplatelet agents (APAs) administration, patients with thrombotic diseases take a fairly high risk of life-threatening bleeding, especially when in need urgent surgery. Rapid functional reversal APAs remains an issue yet to be efficiently resolved by far due the lack any specific agent clinic, which greatly restricts use APAs.Flow cytometry analysis was first applied assess dose-dependent activity platelet-mimicking perfluorocarbon-based nanosponges (PLT-PFCs) toward...