A5024124001- Supramolecular Self-Assembly in Materials
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Animal Virus Infections Studies
- Nanoplatforms for cancer theranostics
- Virus-based gene therapy research
- Advanced Photocatalysis Techniques
- Parvovirus B19 Infection Studies
- Oral Health Pathology and Treatment
- Viral gastroenteritis research and epidemiology
- Photodynamic Therapy Research Studies
- Gas Sensing Nanomaterials and Sensors
- Bacteriophages and microbial interactions
- Oral microbiology and periodontitis research
- Hydrogels: synthesis, properties, applications
- Cancer therapeutics and mechanisms
- Proteoglycans and glycosaminoglycans research
- Dental Health and Care Utilization
- HIV/AIDS drug development and treatment
- Advanced Nanomaterials in Catalysis
- Soil and Water Nutrient Dynamics
- Polydiacetylene-based materials and applications
Sichuan University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
State Key Laboratory of Oral Diseases
2013-2024
General Hospital of Shenyang Military Region
2024
Xi'an Honghui Hospital
2024
Xi'an Jiaotong University
2024
Shandong University
2023
Taiyuan Iron and Steel Group (China)
2023
Soil and Fertilizer Institute of Hunan Province
2022
Hunan Agricultural University
2021-2022
Hydrogels with high mechanical strength and injectability have attracted extensive attention in biomedical tissue engineering. However, endowing a hydrogel both properties is challenging because they are generally inversely related. In this work, by constructing multi-hydrogen-bonding system, high-strength injectable supramolecular successfully fabricated. It constructed the self-assembly of monomeric nucleoside molecular gelator (2-amino-2'-fluoro-2'-deoxyadenosine (2-FA)) distilled...
Abstract Supramolecular hydrogels derived from nucleosides have been gaining significant attention in the biomedical field due to their unique properties and excellent biocompatibility. However, a major challenge this is that there no model for predicting whether nucleoside derivative will form hydrogel. Here, we successfully develop machine learning predict hydrogel-forming ability of derivatives. The optimal with 71% (95% Confidence Interval, 0.69−0.73) accuracy established based on...
Mink enteritis virus (MEV) causes mink viral enteritis, an acute and highly contagious disease whose symptoms include violent diarrhea, which is characterized by high morbidity mortality. Nanoparticle-assisted polymerase chain reaction (nanoPCR) a recently developed technique for the rapid detection of bacterial DNA. Here we describe novel nanoPCR assay clinical epidemiological characterization MEV. This based upon primers specific conserved region MEV NS1 gene, encodes nonstructural protein...
Treatment with KOH increased the number of surface functional groups and tetracycline adsorption at 300 °C, whereas it decreased that 500 700 °C.
Canine parvovirus (CPV) is highly contagious and a major cause of haemorrhagic enteritis myocarditis in dogs. We investigated the genetic variation emerging CPV strains by sequencing 64 VP2 genes from 216 clinical samples dogs Heilongjiang, Jilin, Liaoning, Shandong Hebei 2014. Genetic analysis revealed that CPV-2b was predominant CPV-2a other four provinces. In addition, CPV-2c strain has emerged province. All had Ser-Ala substitution at residue 297 an Ile-Arg 324. Interestingly, five...
Conventional oligonucleotide based drug delivery systems suffer from lengthy synthetic protocols, high cost, and poor chemical or enzymatic stability under certain circumstances. Canonical free individual nucleosides cannot form stable nanostructures in aqueous solution as vehicles. Here, we report the development of a monomeric self-assembled nucleoside nanoparticle (SNNP) into an efficient system which has currently no parallel such field. This was achieved using l-configurational...
Supramolecular hydrogels prepared using low-molecular-weight gelators have attracted considerable attention for biomedical applications. However, in situ supramolecular are limited terms of their prolonged gelation time and/or unstable nature at high temperatures. In this study, we constructed a stable Ag-isoG hydrogel through super-rapid formation, wherein hydrogelation process occurred instantaneously upon mixing isoG and Ag+ within 1 s under ambient conditions. Interestingly, unlike most...
Abstract Aim To evaluate the association between periodontitis, all‐cause and cause‐specific mortality, its prognostic utility among adults with diabetes. Materials Methods Periodontal health records were retrieved from NHANES database for 4297 participants diabetes aged >30 years at baseline during 1988–1994, 1999–2004 2009–2014. Multivariable Cox proportional hazards regression model was applied to calculate hazard ratios (HRs) 95% confidence intervals (CIs) moderate/severe...
A series of novel mesoporous silica materials with ultra-large pores (20 to 40 nm in size), interconnected channel structure, thick walls (15 20 nm), high hydrothermal stability and selective protein adsorption were synthesized via a new synthetic strategy. We used Brij-56 Brij-97 as templates ethyl acetate (EA) dimethyl o-phthalate (DOP) additives neutral pH system afford three spherical (denoted B56-E-20, B56-D-33 B97-D-40) having controllable, mesoscale channels diameters 20, 33 nm,...
Supramolecular self-assembly is not only one of the chemical roots biological structure but also drawing attention in different industrial fields. Here we study mechanism formation a complex flower-shaped supramolecular pyrimido[4,5-d]pyrimidine nucleosides by dynamic light scattering, scanning electron microscopy, differential calorimetry, nuclear magnetic resonance and X-ray analysis. Upon removing hydroxyl group sugars, superstructures can be produced. These works demonstrate that indeed...
Drug-resistant bacterial infections and lack of available antibacterial agents in clinical practice are becoming serious risks to public health. We synthesized a new class haloemodins by modifying traditional Chinese medicine component, emodin. The novel haloemodin exerts strong inhibitory activity on topoisomerase I DNA gyrase, not the topoisomerases human origin. In principle, it shows remarkable activities against laboratory clinically isolated Gram-positive bacteria, including...
The clinical outcome of oral squamous cell carcinoma (OSCC) has not improved in recent years, mainly due to the limited effective targeted therapy that been applied. Recently, a transcriptional coactivator, YAP, shown have key regulatory role malignant progression multiple cancers, including OSCC. But pharmacologically targeting YAP or Hippo pathway, which is main signaling pathway regulating proven be challenging. Therefore, uncovering upstream regulators cancer would identify novel...
COVID-19 pandemic caused by SARS-CoV-2 has become a public health crisis worldwide. In this study, we aimed at demonstrating the neutralizing potential of IgY produced after immunizing chicken with recombinant spike protein S1 subunit.E. coli BL21 carrying plasmid pET28a-S1 was induced IPTG for expression protein. The His-tagged purified and verified SDS-PAGE, Western blot biolayer interferometry (BLI) assay. Then emulsified Freund's adjuvant used to immunize layer chickens. Specific against...