A5054956175- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Fish Ecology and Management Studies
- Nanoparticle-Based Drug Delivery
- Immune Cell Function and Interaction
- Aquatic Ecosystems and Phytoplankton Dynamics
- Cancer Immunotherapy and Biomarkers
- Solar Radiation and Photovoltaics
- Freshwater macroinvertebrate diversity and ecology
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Aquatic Invertebrate Ecology and Behavior
- Marine and coastal ecosystems
- Intraperitoneal and Appendiceal Malignancies
- Visual Attention and Saliency Detection
- Integrated Energy Systems Optimization
- Renal function and acid-base balance
- Potassium and Related Disorders
- Synthesis and Characterization of Heterocyclic Compounds
- Extracellular vesicles in disease
- Digital Radiography and Breast Imaging
- Endometrial and Cervical Cancer Treatments
- Advanced Steganography and Watermarking Techniques
- Advanced Nanomaterials in Catalysis
- Energy Load and Power Forecasting
Hohai University
2022-2024
Commonwealth Scientific and Industrial Research Organisation
2023-2024
Dalian University of Technology
2022
Shandong University
2021
Qilu Hospital of Shandong University
2021
Soochow University
2016-2018
Guangxi Medical University
2016
Southeast University
2015
Sichuan University
2015
Conventional oligonucleotide based drug delivery systems suffer from lengthy synthetic protocols, high cost, and poor chemical or enzymatic stability under certain circumstances. Canonical free individual nucleosides cannot form stable nanostructures in aqueous solution as vehicles. Here, we report the development of a monomeric self-assembled nucleoside nanoparticle (SNNP) into an efficient system which has currently no parallel such field. This was achieved using l-configurational...
Transforming growth factor (TGF)‑β1 is a key cytokine affecting the pathogenesis and progression of cervical cancer. Tumor‑derived exosomes contain microRNAs (miRNAs/miRs) that interact with cancer stromal cells, thereby contributing to tissue remodeling in tumor microenvironment (TME). The present study was designed clarify how TGF‑β1 affects biological functions through released by cells. Deep RNA sequencing found stimulated cells secrete more miR‑663b‑containing exosomes, which could be...
Abstract Background Immune checkpoint blockades (ICBs) therapy showed limited efficacy in ovarian cancer management. Increasing evidence indicated that conventional and targeted therapies could affect tumor-associated immune responses increase the effectiveness of immunotherapy. However, effects Niraparib, one poly (ADP) ribose polymerase (PARP) inhibitors, on response remains unclear. Delineating crosstalk between cytotoxic anticancer agents cancer-associated immunity may lead to more...
Background: Adoptive immunotherapy with cytotoxic T lymphocytes (CTLs) has great potential for the treatment of some malignant cancers.Therefore, augmenting responses tumor-specific CTLs is significant adoptive melanoma.This study aimed to investigate anti-tumor response a combination therapy employing folate-modified chitosan nanoparticles containing IP-10 (interferon-γ-inducible protein-10) plus melanoma TRP2-specific CD8 + CD28 cells.Methods: We prepared mouse gene (FA-CS-mIP-10), and...
With rapid economic and social development, human activities, such as the construction of reservoirs, have satisfied many needs. However, these activities also caused changes in hydrological ecosystem basin, impacting river biodiversity. The establishment Shanxi Reservoir within Feiyun River Basin has inevitably altered system, which was previously shaped primarily by precipitation. This study comprehensively evaluates impact on alteration basin. Two ecological flow indicators, ecosurplus...
Anti-CD105 mAb-conjugated immunoliposomes, loaded with secreted mouse endostatin gene, were developed for targeted tumor imaging and antiangiogenic gene therapy. The liposomes investigated size, zeta-potential, lipid content, antibody binding ability, pcDNA loading capacity. ability of immunoliposomes to target tumor-derived endothelial cells perform transfer in vitro was measured their basic biocompatibility evaluated. A nude mouse/breast cancer xenograft model used examine the...
To investigate the pollution characteristics of surface sediments river–reservoir system in Feiyun River basin, a sediment heavy metal survey was conducted for first time basin. Surface from 21 sampling sites basin were collected, and concentrations spatial distribution 15 metals (Cr, Ni, Cu, Zn, As, Cd, Pb, Mn, V, Co, Mo, Sb, W, Fe, Se) analyzed. Three ecological risk assessment methods used to evaluate potential risks sediments, sources major traced by correlation analysis principal...
It is a major clinical challenge for clinicians how to early find out minimal residual diseases (MRD) of leukemia. Here, we developed smart detection system MRD involving magnetic aptamer sgc8 probe (M-sgc8 probe) capture CEM cells and rolling cycle amplification (RCA-sgc8 initiate RCA, producing single-stranded tandem repeated copy the circular template. The DNA products were hybridized with molecular beacon generate amplified fluorescence signal. An in vitro model mimic was established...
In the present work, a sensitive electrochemical aptasensor was designed for detection of adenosine triphosphate (ATP) with hemin/graphene oxide nanosheets (HGNs). Firstly, ATP aptamer self-assembled on gold electrode surface, and then HGNs were captured to modified by π-π stacking. The could catalyze disproportionation reaction H2O2, produced detectable signal chronoamperometry. competitively bound which led release from surface after adding ATP. decrease signal, calculated difference...
To investigate the structural characteristics and driving factors of metazooplankton community in cascade reservoirs Feiyun River Basin, monitoring surveys were conducted at 18 sampling sites across different seasons: September 2021 (autumn), January 2022 (winter), May (spring), July (summer). These identified 51 species, with highest species abundance observed summer lowest winter. Notably, densities biomasses peaked spring, averaging 13.57 ind./l (where stands for individuals per liter)...
Abstract Background: The high incidence and mortality rates of cervical cancer pose a serious threat to women's health. Traditional chemotherapy has inevitable drawbacks nonspecific tumor targeting, toxicity, poor therapeutic efficiency. In order overcome these shortcomings, novel multifunctional magnetic nanoparticles drug delivery system with targeting resonance imaging was developed achieve precise diagnosis targeted killing effects. Methods: Transmission electron microscopy, dynamic...