A5042357515- Advanced biosensing and bioanalysis techniques
- Electrochemical sensors and biosensors
- Immunotherapy and Immune Responses
- Biosensors and Analytical Detection
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- SARS-CoV-2 detection and testing
- T-cell and B-cell Immunology
- Graphene and Nanomaterials Applications
- Pharmacological Effects and Assays
- Electrochemical Analysis and Applications
- Hepatitis B Virus Studies
- Xenotransplantation and immune response
- RNA Interference and Gene Delivery
- Receptor Mechanisms and Signaling
- Chemokine receptors and signaling
- Supramolecular Self-Assembly in Materials
- vaccines and immunoinformatics approaches
- Nanocluster Synthesis and Applications
- Immune Cell Function and Interaction
Hangzhou Medical College
2022-2024
Zhejiang Provincial People's Hospital
2018-2024
Hangzhou First People's Hospital
2018
Guangxi Medical University
2016-2017
Conventional clinical monotherapies for advanced hepatocellular carcinoma (HCC) have numerous limitations. Integrated oncology approaches can improve cancer treatment efficacy, and photothermal-chemotherapy drug delivery nanosystems (DDS) based on nanotechnology biotechnology piqued the interest of researchers. This study developed an aptamer-modified graphene quantum dots (GQDs)/magnetic chitosan DDS HCC. The HCC aptamer EPR effect nanoparticles, in particular, enable active passive...
A simple, highly sensitive method to detect leukemia cells has been developed based on aptamer-modified fluorescent silica nanoparticles (FSNPs). In this strategy, the amine-labeled Sgc8 aptamer was conjugated carboxyl-modified FSNPs via amide coupling between amino and carboxyl groups. Sensitivity specificity of Sgc8-FSNPs were assessed using flow cytometry fluorescence microscopy. These results showed that detected with high sensitivity specificity. Aptamer-modified hold promise for...
Abstract A cholesterol biosensor was constructed by bimetallic (Au and Pt) poly(amidoamine)-zeolite imidazole framework (PAMAM–ZIF-67). First, PAMAM–ZIF-67 nanomaterial immobilized onto the electrode, then Au Pt were modified on electrode electro-deposition method. Subsequently, oxidase (ChOx) esterase (ChEt) fixed electrode. The stepwise modification procedures recorded impedance spectroscopy voltammetry. current response presented a linear relation to logarithm of content when ranged...
This study aimed to construct a biosensor using Au nanoparticles (Au NPs) and reduced graphene-polyamide-amine-ferrocene (rGO-PAMAM-Fc) nanomaterials designed for rapid sensitive detection of cholesterol.In this study, highly based on NPs/ rGO-PAMAM-Fc was manufactured cholesterol. The NPs were modified the surface electrode then coated with cholesterol oxidase (ChOx) esterase (ChEt) develop ChOx&ChEt/Au NPs/rGO-PAMAM-Fc biosensor.The capability in fabricating more efficient validated...
Stimulus-responsive nanocarrier systems are promising in cancer treatment. They improve drug stability and facilitate controlled release. However, single-responsive nanocarriers still face insufficient tumor targeting low efficacy.In this study, we synthesized folate-modified DSPE-PEOz nanomicelles with PEG chains loaded them magnetic iron particles doxorubicin (DOX). Folic acid (FA) was employed as a ligand to target cells actively. The biocompatible acid-sensitive carriers. Magnetic...
In the present work, a sensitive electrochemical aptasensor was designed for detection of adenosine triphosphate (ATP) with hemin/graphene oxide nanosheets (HGNs). Firstly, ATP aptamer self-assembled on gold electrode surface, and then HGNs were captured to modified by π-π stacking. The could catalyze disproportionation reaction H2O2, produced detectable signal chronoamperometry. competitively bound which led release from surface after adding ATP. decrease signal, calculated difference...
Introduction: Detection of antigen-specific cytotoxic T lymphocytes (CTLs) is the foundation for understanding hepatocellular carcinoma immune pathology and immunotherapy. However, classical method labeling CTLs, major histocompatibility complex (MHC)–peptide tetramer, has drawbacks needs further improvement. Materials methods: Here, as a new detection probe, graphene-based MHC–peptide multimer was developed sensitively selectively identifying carcinoma-specific T-cells. To assess its...
Abstract A highly sensitive electrochemical biosensor was manufactured with triple synergistic catalysis to detect hydrogen peroxide (H 2 O ). In this study, a based on Prussian blue‐chitosan/graphene‐hemin nanomaterial/platinum and palladium nanoparticles (PB‐CS/HGNs/Pt&Pd biosensor) fabricated for the detection of H . The materials described above were modified electrode surface applied catalyze breakdown peroxide. current response presented linear relationship concentration from 6 ×...
Conventional treatments for hepatocellular carcinoma (HCC) lack efficacy and targeting abilities. Photodynamic therapy (PDT) has emerged as a promising alternative targeted minimally invasive tumor treatments. However, many biomaterials used in PDT pose biosafety concerns insufficient enzyme activity often leads to limited reactive oxygen species (ROS) production, resulting poor efficacy. Single-atom nanoenzymes have attracted much research attention novel type of high-performance nanoenzymes.
Detection of human leukocyte antigens-A2-restricted p-hepatitis B virus (HBV) core antigen‑specific cytotoxic T lymphocytes (CTLs) is important in the study HBV immunopathogenesis and vaccine design. Currently, major histocompatibility complex (MHC) class I/peptide‑(p) MHCI tetramers are considered optimal tools to detect CTLs. However, MHC‑tetramer technique also has certain drawbacks under continuous development. The quantum dot (QD) bioconjugates nanotechnology with its unique...