A5101622571- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Lipoproteins and Cardiovascular Health
- Head and Neck Cancer Studies
- Immune cells in cancer
- Inflammatory Biomarkers in Disease Prognosis
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Selenium in Biological Systems
- Adipose Tissue and Metabolism
- Nanofabrication and Lithography Techniques
- Acute Myocardial Infarction Research
- NF-κB Signaling Pathways
- Bone Tumor Diagnosis and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- COVID-19 and healthcare impacts
- Phagocytosis and Immune Regulation
- Biochemical and Structural Characterization
- RNA modifications and cancer
- Extracellular vesicles in disease
- Blood Coagulation and Thrombosis Mechanisms
- Traditional Chinese Medicine Analysis
Zhejiang University
2020-2024
National Clinical Research Center for Digestive Diseases
2024
Army Medical University
2024
Daping Hospital
2024
Shanghai Ninth People's Hospital
2024
Shanghai Jiao Tong University
2024
Shanghai Stomatological Hospital
2024
Macquarie University
2024
XinHua Hospital
2014-2021
Anhui Agricultural University
2018-2020
A simple, highly sensitive method to detect leukemia cells has been developed based on aptamer-modified fluorescent silica nanoparticles (FSNPs). In this strategy, the amine-labeled Sgc8 aptamer was conjugated carboxyl-modified FSNPs via amide coupling between amino and carboxyl groups. Sensitivity specificity of Sgc8-FSNPs were assessed using flow cytometry fluorescence microscopy. These results showed that detected with high sensitivity specificity. Aptamer-modified hold promise for...
The aim of the present study was to investigate immunoregulatory effects <em>Astragalus</em> polysaccharide (APS) on RAW264.7 cells. production cytokines by cells analyzed using ELISA, while cell viability and optimal concentration APS were assessed Cell Counting Kit‑8 assay. In addition, mRNA levels IL‑6, inducible nitric oxide synthase (iNOS) TNF‑α determined reverse transcription‑quantitative PCR analysis. co‑stimulatory molecules cell cycle distribution flow...
The current study is to develop a gentle and efficient method for purification of fibroblast-activation protein positive (FAP+) cancer-associated fibroblasts (CAFs) from tumor tissues. Fresh tissues were isolated BALB/c-Nude mice bearing human liver cancer cell line (HepG2), fully minced separated into three parts, digested with trypsin digestion then treated collagenase type IV once, twice, or thrice, respectively. Finally, the cells purified by using FAP magnetic beads. CAFs grown in...
Background: To evaluate derived neutrophil to lymphocyte ratio (dNLR) in predicting the prognosis of patients with locally advanced oral squamous cell carcinoma (LAOSCC), and survival benefits from docetaxel, cisplatin, 5-FU (TPF) induction chemotherapy (IC); Methods: Patients a phase III trial involving TPF IC stage III/IVA OSCC (NCT01542931) were enrolled. Receiver operating characteristic curves built area under curve was computed determine dNLR cutoff points. Kaplan-Meier estimates Cox...
Radiation therapy can be an effective way to kill cancer cells using ionizing radiation, but some tumors are resistant radiation and the underlying mechanism still remains elusive. It is therefore necessary establish appropriate working model study monitor radiation-mediated therapy. In response cellular stress, metabolome integrated profiling of changes in all metabolites cells, which used investigate tolerance mechanisms identify targets for sensibilization. this study, 1H nuclear magnetic...
Abstract To explore dendritic cells/tumor-derived endothelial cells (DC/EC) fusion are potent stimulators of T to impact tumor progression. ECs were isolated from mice hepatoma cell line (H22) Xenograft, and bone marrow BALB/c mice, then the cultured detected surface expression CD105 by flow cytometry. The characteristics tube formation assay Dil-Ac-LDL uptake assay. After with polyethylene glycol (PEG), we used DCs, ECs, DCs mixed as control groups, DC/EC experimental group, Secretion IFN-α...
Infantile hemangioma (IH), which threatens the physical and mental health of patients, is most common benign tumor in infants. Previously, we found that 15,16-dihydrotanshinone I (DHTS) was significantly more effective at inhibiting proliferation vitro vivo than first-line treatment propranolol. To investigate underlying mechanism DHTS, used EOMA cells as a model to study effect DHTS. We compared transcriptomes control DHTS-treated cells. In total, 2462 differentially expressed genes were...
Pancreatic cancer is a lethal solid malignancy with limited therapeutic options. The development of novel drugs requires adequate new cell line models. A pancreatic line, designated PDXPC1, was established from one ductal adenocarcinoma (PDAC) patient‑derived xenograft. PDXPC1 cells were stably cultured for >2 years and had stable short tandem repeat profile. retained the key mutations primary tumor, along epithelial origin other important protein expression. induced rapid in vivo tumor...
Some patients with COVID-19 rapidly develop respiratory failure or mortality, underscoring the necessity for early identification of those prone to severe illness. Numerous studies focus on clinical and lab traits, but only few attend chest computed tomography. The current study seeks numerically quantify pulmonary lesions using early-phase CT scans calculated through artificial intelligence algorithms in conjunction laboratory helps clinicians identify development illness death a group patients.
ObjectivePrevious studies have shown that apolipoprotein E (ApoE) gene polymorphisms an impact on coronary artery disease(CAD). However, many small sample sizes and different conclusions. The purpose was to retrospectively study the influence of ApoE CAD.MethodsThis assessed genotypes heart disease in patients who received angiography used multivariate logistic regression assess CAD.ResultsPatients with had no obvious differences incidence hypertension, diabetes or obesity(P > 0.05)....
This study aimed to evaluate the derived neutrophil lymphocyte ratio (dNLR) in predicting prognosis of patients with locally advanced oral squamous cell carcinoma (LAOSCC) and assess survival benefits from docetaxel, cisplatin, 5-fluorouracil (5-FU) (TPF) induction chemotherapy (IC).
Gastric cancer (GC) is one of the most malignant cancers worldwide. Metabolism disorder a critical characteristic tumors related to tumor progression and metastasis. However, expression molecular mechanism malic enzyme 3 (ME3) in GC are rarely reported. In this study, we aim investigate ME3 development explore its potential value as prognostic therapeutic target GC.
Abstract Background: Elevated lipoprotein(a) (Lp[a]) is a risk factor for first atherosclerotic thrombosis events, but the role of elevated Lp(a) in secondary prevention controversial. This study aimed to retrospectively investigate influence levels on prognosis patients with coronary artery disease. Methods: The team collected and compared clinical information hospitalized during percutaneous intervention (PCI). used multivariate logistic regression model evaluate relationships between...