A5101618956- Estrogen and related hormone effects
- Multiple Myeloma Research and Treatments
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Cancer Research and Treatments
- Glycosylation and Glycoproteins Research
- Drug Transport and Resistance Mechanisms
- Angiogenesis and VEGF in Cancer
- Liver physiology and pathology
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Molecular Biology Techniques and Applications
- Cell death mechanisms and regulation
- Protein Degradation and Inhibitors
- Blood Coagulation and Thrombosis Mechanisms
- Signaling Pathways in Disease
- RNA and protein synthesis mechanisms
Second Affiliated Hospital of Zhejiang University
2011-2024
First Hospital of Qinhuangdao
2024
Qingdao Center of Resource Chemistry and New Materials
2024
Zhejiang University
2008-2023
Xuzhou Medical College
2022
Nanjing Medical University
2022
First People’s Hospital of Zunyi
2022
PLA Academy of Military Science
2022
Zunyi Medical University
2022
Ningxia Medical University
2021-2022
Abstract The lg VH region sequence in 48 patients with multiple myeloma (MM) was analyzed to characterize the malignant cell of origin. sequences were obtained after amplification bone marrow cDNA by using family-specific and CH primers, then compared either directly sequenced patient germ-line or published gen assay for somatic mutation. Because hypermutation gene occurs late B development, its presence has been helpful determining origin other malignancies. Overall, a median 8.2%...
Neuroinflammation following spinal cord injury (SCI) results in prolonged neurological damage and locomotor dysfunction. Polarization of microglia is vital to regulation neuroinflammation, although the underlying mechanisms have not yet been elucidated. Endocannabinoid receptor subtype 2 (CB2R) reported ameliorate neurodegeneration via immunomodulation activities. However, machinery context SCI remains unclear.A lipopolysaccharide-induced inflammation model a mouse were employed investigate...
Acquired tamoxifen (TAM) resistance limits the therapeutic benefit of TAM in patients with hormone‐dependent breast cancer. The switch from estrogen‐dependent to growth factor‐dependent is a critical step this process. However, molecular mechanisms underlying remain poorly understood. In study, we established resistant cell sub line (MCF‐7/TAM) estrogen receptor‐α (ER‐α66) positive cancer MCF‐7 cells by culturing ER‐α66‐positive medium plus 1 μM over 6 months. MCF‐7/TAM were then found...
Recent technological advancements have shown tremendous mechanistic accomplishments in our understanding of the mechanism messenger RNA translation eukaryotic cells. Eukaryotic is very complex process that includes four phases (initiation, elongation, termination, and ribosome recycling) diverse mechanisms involving protein non-protein molecules. Translation regulation principally achieved during initiation step translation, which organized by multiple factors. factor proteins help...
Tamoxifen(TAM) is one of the most effective endocrine treatment for estrogen receptor(ER)-positive breast cancer, however drug resistance greatly limits benefit it. Our purpose to uncover role Beclin 1 in tamoxifen and prognosis ER positive cancer. We established a resistant ER-positive cancer cell subline MCF-7R presenting with higher human epidermal growth factor receptor 2(HER2) levels than MCF-7. Silencing decreased HER2 significantly promoted TAM sensitivity MCF-7 vitro. Overexpression...
Human leucine zipper transcription factor-like 1 (LZTFL1) is a novel gene with unknown biological functions. It located in the chromosome region 3p21.3, hotspot for tumor suppressor genes. To understand functions of LZTFL1, we surveyed expression level LZTFL1 and normal samples tissue microarrays clinical archive 84 gastric cancer specimens using immunohistochemistry. We found that expressed highly epithelial cells tissues significantly downregulated corresponding samples. The correlated...