A5009093556- Cancer Research and Treatments
- Virus-based gene therapy research
- Colorectal Cancer Treatments and Studies
- Angiogenesis and VEGF in Cancer
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Bacteriophages and microbial interactions
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Nanoparticle-Based Drug Delivery
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
- Colorectal Cancer Surgical Treatments
- Extracellular vesicles in disease
- Lung Cancer Treatments and Mutations
- Metastasis and carcinoma case studies
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Cancer Treatment and Pharmacology
- RNA Interference and Gene Delivery
Zhejiang Chinese Medical University
2024-2025
Zhejiang University
2015-2024
Hangzhou First People's Hospital
2024
Westlake University
2024
Jinhua Central Hospital
2024
Jinhua Academy of Agricultural Sciences
2020-2024
Hangzhou Medical College
2023
University of Colombo
2021
Shaoxing People's Hospital
2015-2020
Taizhou People's Hospital
2019
As a third-generation platinum drug, oxaliplatin (OX) is widely used as the first-line chemotherapeutic agent in treatment of colorectal cancer (CRC). CRC cells acquire resistance to chemotherapy and develop resistance, which major challenge for advanced CRC. Recent studies have suggested that therapeutic tumors affected by tumor microenvironment (TME). critical role among TME, tumor-associated macrophages (TAMs) play an important role. However, their regulatory mechanism underlying drug...
Luteolin is a flavonoid, which has been extensively investigated due to its antitumor effects; however, the underlying mechanisms of action remain largely unknown. The present study aimed investigate role luteolin in breast cancer (BC), and explored how suppresses growth induces apoptosis BC cells. MTS assay was used determine anticancer activity luteolin. Colony formation Transwell assays were performed evaluate effects on cell invasion. Cell cycle progression analyzed by flow cytometry. In...
Chemotherapy drugs are cytotoxic to tumor cells, but their lack of specificity leads a range side effects. The off-target effects such can be improved through the use nanoparticles (NPs). Administered NPs show enhanced accumulation in tissue near blood vessels, enhancing both anticancer drug permeability and retention. Several nanocarriers now approved for clinical cancer therapies, many novel formulations later stages trials. Here, we describe advances this area review NP developed over...
Acquired tamoxifen (TAM) resistance limits the therapeutic benefit of TAM in patients with hormone‐dependent breast cancer. The switch from estrogen‐dependent to growth factor‐dependent is a critical step this process. However, molecular mechanisms underlying remain poorly understood. In study, we established resistant cell sub line (MCF‐7/TAM) estrogen receptor‐α (ER‐α66) positive cancer MCF‐7 cells by culturing ER‐α66‐positive medium plus 1 μM over 6 months. MCF‐7/TAM were then found...
Cancer is a complex process in which protein-coding and non-coding genes play essential roles. Long noncoding RNAs (lncRNAs), as subclass of genes, are implicated various cancer processes including growth, proliferation, metastasis, angiogenesis. Due to presence body fluids such blood urine, lncRNAs have become novel biomarkers detection, diagnosis, progression, therapy response. Remarkably, increasing evidence has verified that roles chemoresistance by targeting different signalling...
Abstract Alpha-fetoprotein producing gastric carcinoma (AFPGC) is a rare and aggressive subtype of cancer. However, little known about the genomic features this disease. We perform whole-exome sequencing analysis AFPGC, identify 34 significantly mutated genes. Somatic copy number alterations reveals several significant focal amplifications (e.g. 19q12, 17q12) deletions 1p36.11, 9p21.3), some these negatively affect patient prognosis. Comparative analyses reveal that AFPGC has distinct from...
The pharmacological approach to treating gastrointestinal diseases is suffering from various challenges. Among such diseases, ulcerative colitis manifests inflammation at the colon site specifically. Patients notably exhibit thin mucus layers that offer increased permeability for attacking pathogens. In majority of patients, conventional treatment options fail in controlling symptoms disease leading distressing effects on quality life. Such a scenario due failure therapies target loaded...
Breast cancer (BCa) is known as a complex and prevalent disease requiring the development of novel anticancer therapeutic approaches. Bispecific antibodies (BsAbs) have emerged favorable strategy for BCa treatment due to their unique ability target two different antigens simultaneously. By targeting tumor-associated (TAAs) on cells, engaging immune effector or blocking critical signaling pathways, BsAbs offer enhanced tumor specificity system involvement, improving anti-cancer activity....