A5100622011- Estrogen and related hormone effects
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Viral-associated cancers and disorders
- Thyroid Cancer Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Lymphoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Liver physiology and pathology
- Synthesis and biological activity
- Genetic factors in colorectal cancer
- Neurogenesis and neuroplasticity mechanisms
- Melanoma and MAPK Pathways
- Ubiquitin and proteasome pathways
- Cancer, Stress, Anesthesia, and Immune Response
- Meningioma and schwannoma management
- Cancer-related gene regulation
- Genetic Syndromes and Imprinting
- Ovarian cancer diagnosis and treatment
- Effects of Environmental Stressors on Livestock
- Prostate Cancer Treatment and Research
- Amyotrophic Lateral Sclerosis Research
Nanchang University
2025
First Affiliated Hospital Zhejiang University
2013-2022
Shaanxi Normal University
2022
Zhejiang University
2011-2021
Beckman Research Institute
2014
City of Hope
2014
Northeast Institute of Geography and Agroecology
2013
Chinese Academy of Sciences
2013
Southern Medical University
2002
Nanfang Hospital
2002
Aberrated activation of cMet in gastric cancer contributes to tumor growth, angiogenesis and metastasis. cMet-overexpressing has a poor prognosis because high metastasis limited therapeutic options. Luteolin is common dietary flavonoid with antitumor properties. However, the effect luteolin on remain unclear. Two patient-derived human xenograft (PDTX) models were established, treated or vehicle evaluate effects luteolin. Tumor specimens subjected H&E staining immunohistochemistry. MKN45...
<h3>Objective</h3> Raf kinase inhibitor protein (RKIP) appears to control cancer cell metastasis and its expression in colonic tissue is related development. We sought identify the roles of RKIP maintaining homeostasis GI tract. <h3>Design</h3> The was determined by immunohistochemistry western blot analysis. knockout wild-type mice were administered dextran sulfate sodium (DSS) or 2,4,6-trinitrobenzenesulfonic acid (TNBS) induce experimental colitis, assessed based on colitis symptoms...
Acquired tamoxifen (TAM) resistance limits the therapeutic benefit of TAM in patients with hormone‐dependent breast cancer. The switch from estrogen‐dependent to growth factor‐dependent is a critical step this process. However, molecular mechanisms underlying remain poorly understood. In study, we established resistant cell sub line (MCF‐7/TAM) estrogen receptor‐α (ER‐α66) positive cancer MCF‐7 cells by culturing ER‐α66‐positive medium plus 1 μM over 6 months. MCF‐7/TAM were then found...
Aim: The purpose of this work is to determine if tumor-tropic neural stem cells (NSCs) can improve the tumor-selective distribution and retention nanoparticles (NPs) within invasive brain tumors. Materials & methods: Streptavidin-conjugated, polystyrene NPs are surface-coupled biotinylated human NSCs. These large (798 nm), yet when conjugated tropic cells, they too passively diffuse through tissue or cross blood–tumor barrier. NP was quantified 4 days after injections located either adjacent...
Increasing evidence has shown that the transcription factor SOX4 is closely associated with development and progression of many malignant tumors. However, effect on breast cancer unclear. In this study, we purposed to investigate role in growth metastasis underlying mechanism. Moreover, cell resistance chemotherapeutic agents was also evaluated vitro vivo.We used lentivirus technique ectopically express MDA-MB-231 SUM149 cells or knockdown BT474 cells, examined these changes various cellular...
Abstract Alpha-fetoprotein producing gastric carcinoma (AFPGC) is a rare and aggressive subtype of cancer. However, little known about the genomic features this disease. We perform whole-exome sequencing analysis AFPGC, identify 34 significantly mutated genes. Somatic copy number alterations reveals several significant focal amplifications (e.g. 19q12, 17q12) deletions 1p36.11, 9p21.3), some these negatively affect patient prognosis. Comparative analyses reveal that AFPGC has distinct from...
Gastric cancer (GC) is one of the leading causes deaths with high heterogeneity. There currently a paucity clinically applicable molecular classification system to guide precise medicine.A total 70 Chinese patients GC were included in this study and whole-exome sequencing was performed. Unsupervised clustering undertaken identify genomic subgroups, based on mutational signature, copy number variation, neoantigen, clonality, essential alterations. Subgroups characterized by...
Abstract Aims Cerebral ischemia can lead to anxiety and cognitive impairment due the loss of hippocampal neurons. Facilitation endogenous neurogenesis in hippocampus is a potential therapeutic strategy for alleviating ischemia‐induced impairment. Progranulin (PGRN), secretory glycoprotein, has been reported have mitogentic effect on many cell types. However, it not clear whether PGRN enhances promotes functional recovery. Methods Adult male C57BL/6 mice were subjected permanent middle...
The prognostic value of geriatric nutritional risk index (GNRI) for diffuse large B-cell lymphoma (DLBCL) treated in the rituximab era was not clear.To investigate impact GNRI patients with DLBCL our hospital.DLBCL were recruited and classified into two groups without malnutrition based on GNRI. Clinical features, concentration T-helper cell type (Th1/Th2/Th17) cytokine profiles overall survival compared between these groups.One hundred five (39%) out 267 group. Patients had lower levels...
Aberrant activation of the signal transducer and activator transcription 3 (STAT3) is frequently seen in patients with gastric cancer (GC), generally associated worse prognosis. HJC0152, a novel STAT3 inhibitor, has shown significant anti-tumor effects several cancers, although its role GC remains to be clarified.The effect HJC0152 on signaling pathway biological behaviors cells were evaluated through vitro and/or vivo experiments. Meanwhile, RNA sequence analysis was used further explore...
Extranodal follicular dendritic cell (FDC) sarcomas are not a common phenomenon. Due to the scarcity of identified cases reported in literature, FDC is probably under-recognized and commonly misdiagnosed. The diagnosis based on node-based spindle lesions, expression CD21, CD35 clusterin. most involved extranodal sites include oral cavity, tonsil, gastrointestinal tract liver. With aid immunohistochemical analysis two reliable markers, CD21 CD35, diagnostic accuracy has improved. When sarcoma...
Acquired tamoxifen resistance is one of the major barriers to successful treatment breast cancer. Recently, overexpression ERα36 was demonstrated be a potential mechanism for generation acquired resistance. This study aims evaluate possibility being therapeutic target tamoxifen-resistant cancer.A cell subline (MCF-7/TAM) established by culturing MCF-7 cells in medium plus 1 μM over 6 months. Colony-forming assay used determine sensitivity MCF-7/TAM tamoxifen. Stable transfection knockdown...
This study aimed to evaluate the prognostic value of preoperative plasma intermedin levels in breast cancer patients. Plasma 252 women and 100 healthy were determined using radioimmunoassay kit. Adverse event was defined as first local recurrence, distant metastasis, second primary another organ, or death from any cause during 5-year follow-up. Disease-free survival time between surgery date adverse whichever appeared first. Overall for cause. The relationships clinical outcomes patients...
BP‑1‑102, a novel inhibitor of signal transducer and activator transcription 3 (STAT3), exhibits significant antitumor effects in several malignancies vitro vivo. However, its role gastric cancer (GC) remains to be elucidated. In the present study, effect potential molecular mechanisms BP‑102 human GC cell lines were investigated. The results showed that BP‑1‑02 dose‑dependently inhibited proliferation AGS cells, whereas it had little on HGC‑27 cells. Flow cytometric analysis indicated...
A 62‑year‑old female with neurofibromatosis type 1 (NF1; also von Recklinghausen's disease) was diagnosed a giant, thick‑walled tubular mass, mainly located in the right abdominal area on computed tomography, following an examination for intermittent pain and increasing distension. According to clinical manifestations imaging features, giant mass considered most likely be dilated fallopian tube associated infection, while possibility of obstructed bowel loops excluded. However, subsequent...
Previous studies have demonstrated that 99mTc-sestamibi (99mTc-MIBI) Single-Photon Emission Computed Tomography/ Tomography (SPECT/CT) imaging is an effective isotopic technique for locating the parathyroid in secondary hyperparathyroidism (SHPT). This study aimed to explore further correlation between 99mTc-MIBI SPECT/CT and SHPT demonstrate value of evaluating degree pathological hyperplasia gland (PG).The demographics, surgical records, follow-up information 91 patients were recorded...
Abstract Purpose Increasing evidence has shown that the transcription factor SOX4 is closely associated with development and progression of many malignant tumors. However, effect on breast cancer unclear. In this study, we purposed to investigate role in growth metastasis underlying mechanism. Moreover, cell resistance chemotherapeutic agents was also evaluated vitro vivo . Methods We used lentivirus technique ectopically express MDA-MB-231 SUM149 cells or knockdown BT474 cells, examined...
Carcinosarcoma is a rare malignant neoplasm comprising both epithelial and mesenchymal components. Hepatoid adenocarcinoma (HAC) another type of cancer. To date, there are only four reported cases concurrent carcinosarcomas with HAC across all tumor types, which were observed in uterine tumors. Here, we report an unusual case gastric carcinosarcoma associated alpha-fetoprotein (AFP)-producing 76-year-old woman. Upon admission, the patient had elevated serum AFP concentration (448 µg/L),...