A5024702393- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Air Quality and Health Impacts
- Gastric Cancer Management and Outcomes
- Cytokine Signaling Pathways and Interactions
- Breast Cancer Treatment Studies
- Esophageal Cancer Research and Treatment
- Cancer Treatment and Pharmacology
- Breast Lesions and Carcinomas
- Diabetes and associated disorders
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
Second Affiliated Hospital of Xi'an Jiaotong University
2016-2025
Xijing Hospital
2025
Tianjin Medical University Cancer Institute and Hospital
2013-2025
Air Force Medical University
2025
Chengdu Third People's Hospital
2025
Zhejiang University
2012-2024
First Affiliated Hospital Zhejiang University
2013-2024
Brigham and Women's Hospital
2024
Harvard University
2024
University College London
2024
Abstract Background Statistical data on the incidence, mortality, and burden of breast cancer relevant risk factors are valuable for policy-making. We aimed to estimate deaths, disability-adjusted life years (DALYs) by country, gender, age group, social-demographic status between 1990 2017. Methods extracted from 2017 Global Burden Disease (GBD) study through in 195 countries territories. Data about number incident cases, DALYs, age-standardized rates were collected. also estimated...
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to proliferative tumor cells, serves as a conduit for migration. Targeting oncogenes involved in angiogenesis needed treat organ-confined locally advanced ESCC. Although phospholipase C epsilon-1 (PLCE1) gene was originally identified susceptibility ESCC, how PLCE1 ESCC unclear. Matrix-assisted laser desorption ionization time-of-flight mass...
Chronic kidney disease (CKD) is a public health problem largely caused by diabetes. The epidemiology of diabetes mellitus-related CKD (CKD-DM) could provide specific support to lessen global, regional, and national burden.Data were derived from the GBD 2019 study, including four measures age-standardized rates (ASRs). Estimated annual percentage changes 95% CIs calculated evaluate variation trend ASRs.Diabetes majority new cases patients with in all regions. All ASRs for type 2...
Abstract Background Investigations of disease incidence, mortality, and disability-adjusted life years (DALYs) are valuable for facilitating preventive measures health resource planning. We examined the tracheal, bronchus, lung (TBL) cancer burdens worldwide according to sex, age, social development index (SDI) at global, regional, national levels. Methods assessed TBL burden using data from Global Burden Disease (GBD) database, including 21 regions, 195 countries, territories in diagnostic...
Cervical cancer (CC) is a leading cause of cancer-related death in women. Limited studies have investigated whether immune-related genes (IRGs) or tumor immune microenvironment (TIME) could be indicators for CC prognoses. The aim this study was to develop an improved prognostic signature based on IRGs TIME predict survival and response checkpoint inhibitors (ICIs). A constructed using bioinformatics method its predictive capability validated. mechanisms underlying the signature's were...
Abstract Background Hodgkin lymphoma (HL) is an uncommon B cell lymphoma. We assessed the global, regional, and national burden of HL from 1990 to 2017, by gender, age, social-demographic index (SDI). Methods Data on HL, including incidence, mortality, disability adjusted life-years (DALY), 2017 were obtained Global Burden Disease study. Estimated annual percentage changes (EAPCs) calculated assess incidence rate, DALY trends. Results incidences increased 38.66%, 72,937 in 101,133 while...
Abstract Background The epidemiology of esophageal cancer (EC) can elucidate its causes and risk factors help develop prevention strategies. We aimed to provide an overview the burden, trends, EC in China from 1990 2017. also investigated differences between China, Japan, South Korea discussed possible disparities. Methods used Global Burden Disease Study 2017 obtain data on incident cases, deaths, disability-adjusted life-year (DALY) age-standardized incidence rate (ASIR), death (ASDR),...
Larynx cancer is one of the most common cancers in head and neck. This study aimed to investigate health burden larynx at global, regional, national levels. We collected data between 1990 2017 from Global Burden Disease study, including incidence, mortality, disability adjusted life-years (DALYs). Estimated annual percentage changes (EAPCs) were calculated assess age-standardized rate (ASR) cancer. From 2017, LC incident cases increased by 58.67%; however, incidence (ASIR) decreased, with an...
Background The patterns of the incidence and mortality prostate cancer (PC) have been changing over years. In addition, unclear etiology PC necessitates further studies into geographic distribution age composition patients with PC. This study was aimed at examining epidemiology to help policymakers allocate limited resources health care system accordingly. Methods Annual case data age‐standardized rates (ASRs) were obtained for incidence, mortality, disability‐adjusted life‐years (DALYs)...
The concept of spatially fractionated radiation therapy (SFRT) was conceived over 100 years ago, first in the form GRID, which has been applied to clinical practice since its early inception and continued present even with markedly improved instrumentation therapy. LATTICE (LRT) introduced 2010 as a conceptual 3D extension GRID several uniquely different features. Since 2014, when patient treated, 150 patients bulky tumors worldwide have received LRT. Through brief review basic principles...
Cancer is the leading cause of death among children.We report on latest estimates burden cancer children at global, regional, and national levels from 1990 to 2019.Based Global Burden Disease Study 2019, children's data were analyzed by sex, age, year, location. Age-standardized rates used compare burdens regions nations. Joinpoint analysis was applied assess temporal trend global childhood burden.In 291,319 (95% uncertainty interval [UI], 254,239 331,993) new cases 98,834 (86,124 113,581)...
<h3>Importance</h3> It is difficult for policy makers and clinicians to formulate targeted management strategies mesothelioma because data on current epidemiological patterns worldwide are lacking. <h3>Objective</h3> To evaluate the burden across world describe its distribution over time by sociodemographic index (SDI) level, geographic location, sex, age. <h3>Design, Setting, Participants</h3> Annual case age-standardized rates of incidence, death, disability-adjusted life-years associated...
Introduction This study aimed to describe the latest epidemiology of female breast cancer globally, analyze change pattern incidence rates and disease’s association with age, period, birth cohort, subsequently present a forecast incidence. Methods Data for analysis were obtained from Global Burden Disease (GBD) Study 2019 World Population Prospects revision by United Nations (UN). We described age-standardized (ASIRs) 1990 then calculated relative risks period cohort using an...
Colorectal cancer (CRC) arises from complex interactions between host and environment, which include the gut tissue microbiome. It is hypothesized that epigenetic regulation by microbiota a fundamental interface commensal microbes dynamically influence intestinal biology. The aim of this study to explore interplay DNA methylation in CRC.
Cardiovascular calcification is one of the most severe outcomes associated with cardiovascular disease and often results in significant morbidity mortality. Previous reports indicated that epigenomic regulation microRNAs (miRNAs) might play important roles vascular smooth muscle cell (VSMC) calcification. Here, we identified potential key miRNAs involved vivo investigated role miR-32-5p (miR-32). According to microarray analysis, observed increased expression miR-125b, miR-30a, miR-32...
Abstract Introduction It remains unclear whether marital status could affect the breast cancer‐caused special survival (BCSS) of patients with cancer. Therefore, we sought to explore influence demographic and pathological factors on prognosis Materials methods We selected meeting eligibility criteria from Surveillance, Epidemiology, End Results (SEER) cancer registry program. assessed effect overall (OS) BCSS using Kaplan‐Meier curve multivariate Cox proportional hazards regression. Compared...
Immune checkpoint inhibitors (ICIs) have been successfully used for treating melanoma and non-small cell lung cancer. However, many patients with breast cancer (BC) show low response to ICIs due the paucity of infiltrating immune cells. Pseudogenes, as a particular kind long-chain non-coding RNA, play vital roles in tumorigenesis, but their potential tumor immunology remain unclear. In this study that data from online databases, novel pseudogene HLA-DPB2 its parental gene HLA-DPB1 were...
<h3>Importance</h3> Occupational exposure to carcinogens has been shown pose a serious disease burden at the global, regional, and national levels. Based on epidemiologic studies clinical observations, working environment appears have important effects occurrence of human malignant tumors; however, date, no systematic articles published that specifically investigated cancer due occupational in an individual collective manner. <h3>Objective</h3> To estimate degree evaluate attributable (OCs)...
Background: Colorectal cancer remains a public health problem worldwide. Dietary risk factors play key role in the carcinogenesis and progression of colorectal cancer. This study aimed to explore geographical temporal trends various dietary factor-related cancers. Methods: Data were extracted from Global Burden Disease (GBD) 2019 study, including deaths, disability-adjusted life-years (DALYs), age-standardized rate (ASR), summary exposure value (SEV) among 4 world regions, 11 age groups, 21...
The aim of the study was to investigate efficacy and safety St John's wort extract selective serotonin reuptake inhibitors (SSRIs) in treatment depression.Databases were searched for studies comparing and/or with SSRIs depression from 1966 April 2015. Stata software used statistical analysis.Twenty-seven met entry criteria. A total 3,126 patients included. did not differ clinical response, remission, mean reduction Hamilton Rating Scale Depression score. had a significantly lower rate...