A5101753413- Mitochondrial Function and Pathology
- Cholesterol and Lipid Metabolism
- Lipid Membrane Structure and Behavior
- MicroRNA in disease regulation
- Sphingolipid Metabolism and Signaling
- TGF-β signaling in diseases
- RNA modifications and cancer
- Developmental Biology and Gene Regulation
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Supramolecular Self-Assembly in Materials
- Connexins and lens biology
- Metabolism and Genetic Disorders
- Epigenetics and DNA Methylation
- ATP Synthase and ATPases Research
- Cancer-related gene regulation
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- Heavy metals in environment
- Inflammatory mediators and NSAID effects
- Metabolomics and Mass Spectrometry Studies
- Circular RNAs in diseases
- Galectins and Cancer Biology
- Plant Growth Enhancement Techniques
- Biomarkers in Disease Mechanisms
Nanjing Agricultural University
2025
Guiyang Medical University
2021-2024
Affiliated Hospital of Guizhou Medical University
2024
Qilu Hospital of Shandong University
2019-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Children's Hospital of Zhejiang University
2018-2021
Zhejiang University
2016-2021
Women's Hospital, School of Medicine, Zhejiang University
2021
First Affiliated Hospital of University of South China
2012-2018
University of South China
2009-2018
Multidrug resistance is a serious barrier to successful treatment of many human diseases, including cancer, wherein chemotherapeutics are exported from target cells by membrane-embedded pumps. The most prevalent these pumps, the ATP-Binding Cassette transporter P-glycoprotein (P-gp), consists two homologous halves each comprising one nucleotide-binding domain and six transmembrane helices. region encapsulates hydrophobic cavity, accessed portals in membrane, that binds cytotoxic compounds as...
Cardiovascular calcification is one of the most severe outcomes associated with cardiovascular disease and often results in significant morbidity mortality. Previous reports indicated that epigenomic regulation microRNAs (miRNAs) might play important roles vascular smooth muscle cell (VSMC) calcification. Here, we identified potential key miRNAs involved vivo investigated role miR-32-5p (miR-32). According to microarray analysis, observed increased expression miR-125b, miR-30a, miR-32...
Urban waterfront areas, which are essential natural resources and highly perceived public areas in cities, play a crucial role enhancing urban environment. This study integrates deep learning with human perception data sourced from street view images to the relationship between visual landscape features of employing linear regression random forest models predict along coastal roads. Based on aesthetic distinctiveness perception, roads Xiamen were classified into four types different emphasis...
Mtu1(Trmu) is a highly conserved tRNA modifying enzyme responsible for the biosynthesis of τm5s2U at wobble position tRNAGln, tRNAGlu and tRNALys. Our previous investigations showed that MTU1 mutation modulated phenotypic manifestation deafness-associated mitochondrial 12S rRNA mutation. However, pathophysiology deficiency remains poorly understood. Using mtu1 knock-out zebrafish generated by CRISPR/Cas9 system, we demonstrated abolished 2-thiouridine modification U34 tRNALys, tRNAGln in...
S100A13 and high mobility group A (HMGA1) are known to play essential roles in the carcinogenesis progression of cancer. However, correlation between HMGA1 during cancer is not yet well understood. In this study, we determined effects on expression thyroid cells examined role progression. Stable ectopic TT cellular proliferation was evaluated by nude mice xenografts assays. The effect lentivirus-mediated knockdown oncogenic properties were MTT, colony formation assays transwell TPC1 SW579...
A challenging requirement for structural studies of integral membrane proteins (IMPs) is the use amphiphiles that replicate hydrophobic environment membranes. Progress has been impeded by limited number useful detergents and need a deeper understanding their structure−activity relationships. To this end, we designed family containing short, branched alkyl chains at interface between polar head apolar tail. This design mimics second aliphatic chain lipid molecules reduces water penetration,...
Deficient maturations of mitochondrial transcripts are linked to clinical abnormalities but their pathophysiology remains elusive. Previous investigations showed that pathogenic variants in MTO1 for the biosynthesis τm5U tRNAGlu, tRNAGln, tRNALys, tRNATrp and tRNALeu(UUR) were associated with hypertrophic cardiomyopathy (HCM). Using mto1 knock-out(KO) zebrafish generated by CRISPR/Cas9 system, we demonstrated pleiotropic effects Mto1 deficiency on RNA maturations. The perturbed structure...
The high detected frequencies of hexaconazole (Hex) and arsenic (As) increased the probabilities their co-existence in agricultural products. However, combined toxicity effect mechanism action for these two pollutants were still unclear. In this study, an untargeted metabolomics method with ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was developed to monitor changes endogenous metabolites metabolism pathways mice liver. Our study revealed that significant...
Transforming growth factor-β1 (TGF-β1) signaling and high mobility group A (HMGA1) are known to play essential roles in the progression of breast cancer by inducing epithelial-mesenchymal transition. However, correlation between TGF-β1 HMGA1 cell is not yet well understood. In this study, we determined effects on expression cells examined role progression. Our results demonstrated that induced both MCF-7 MDA-MB-231 cells, as shown RT-qPCR immunofluorescence staining; however, TGF-β1-induced...
Abstract In this report, we investigated the molecular mechanism underlying a deafness-associated m.7516delA mutation affecting 5′ end processing sites of mitochondrial tRNAAsp and tRNASer(UCN). An in vitro experiment demonstrated that caused aberrant tRNASer(UCN) precursors, catalyzed by RNase P. Using cytoplasmic hybrids (cybrids) derived from one hearing-impaired Chinese family bearing control, asymmetrical effects on tRNAs heavy (H)-strand light (L)-strand polycistronic transcripts....