A5025951726- MicroRNA in disease regulation
- Thyroid Disorders and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Autophagy in Disease and Therapy
- Ocular Surface and Contact Lens
- Circular RNAs in diseases
- Corneal Surgery and Treatments
- Ionic liquids properties and applications
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cardiac Ischemia and Reperfusion
- Pregnancy and preeclampsia studies
- Retinal and Optic Conditions
- Advanced Glycation End Products research
- Cytomegalovirus and herpesvirus research
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Glaucoma and retinal disorders
- Technology and Security Systems
- Ocular Oncology and Treatments
- Hair Growth and Disorders
- Intraocular Surgery and Lenses
- Mitochondrial Function and Pathology
- Retinal Diseases and Treatments
- Genetic and rare skin diseases.
Yuhuangding Hospital
2015-2024
Qingdao University
2017-2024
Hunan Academy of Traditional Chinese Medicine
2015-2024
Tianjin Medical University
2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2023-2024
Shanghai Institute of Geological Survey
2024
Yunnan Metallurgical Group (China)
2024
Harbin Institute of Technology
2019-2023
Sichuan University
2023
West China Hospital of Sichuan University
2023
To examine the relationship between specific thyroid abnormalities (subclinical hypothyroidism, hypothyroxinaemia or elevated peroxidase antibody titres) in women during pregnancy and subsequent neuropsychological development of their offspring.Serum was collected from 1268 at 16-20 weeks gestation stimulating hormone (TSH), total thyroxine (tT(4)), free (fT(4)), Thyroid antibodies (TPOAb) levels were measured. function reference ranges for used to screen abnormalities. Patients with...
With the introduction of iodized salt worldwide, more and people are exposed to than adequate iodine intake levels with median urinary excretion (MUI 200-300 μg/l) or excessive >300 μg/l). The objective this study was explore associations between development thyroid diseases (e.g. dysfunction, autoimmunity, structure) in two Chinese populations.A population-based cross-sectional conducted areas which different (Rongxing, MUI 261 μg/l; Chengshan, 145 A total 3813 individuals were recruited by...
An ultrasonication-assisted synthesis of alcohol-based deep eutectic solvents (DESs) is described. Several DESs were synthesized simultaneously under the same conditions. The prepared used for extraction gingerols from ginger powder via extraction. Notably, some exhibited superior performance than those in traditional organic solvents. viscosity DESs, which was suggested to be typically lower 100 mPa*s had a critical effect on performance. However, higher gingerol contents extracts did not...
Doxorubicin (DOX) is an anthracycline drug with a wide spectrum of antineoplastic activities. However, it causes cardiac cytotoxicity, and this limits its clinical applications. MicroRNA-21 (miR-21) plays vital role in regulating cell proliferation apoptosis. While miR-21 preferentially expressed adult cardiomyocytes involved development heart disease, little known regarding biological functions responding to DOX-induced cytotoxicity. In study, the effects DOX on mouse function expression...
Abstract Our previous study demonstrated that angiogenesis increased during the recovery of heat-denatured endothelial cells. However, mechanism is still unclear. This aimed to investigate relation autophagy and A rat deep partial-thickness burn model human umbilical vein cells (HUVECs) (52 °C for 35 s) were used. Autophagy significantly in dermis HUVECs a time-dependent manner after heat denaturation 2–5 days. Rapamycin-mediated enhanced pro-angiogenic effect, evidenced by proliferation...
Selenium (Se) is required for thyroid hormone synthesis and metabolism. Se treatment reduces serum thyroidspecific antibody titers in patients with autoimmune thyroiditis (AIT), but the exact mechanism not clear. We investigated effects of on CD4+CD25+Foxp3+ regulatory T cells (Treg) a iodine-induced model. NOD.H-2h4 mice were randomly divided into control, AIT untreated, groups. Mice fed 0.005% sodium iodine (NaI) water 8 weeks to induce AIT. Se-treated received 0.3 mg/L selenite drinking...
MaPa, which was combined by strong interaction, used in the extraction of HT from olive leaves combination with ultrasound treatment. The MaPa extract had good biocompatibility and excellent antioxidant, bacteriostatic anti-inflammatory effects.
Vaspin (visceral adipose tissue-derived serine protease inhibitor) is a recently discovered adipokine that has been implicated in diabetes mellitus and other metabolic disorders. However, the effects of vaspin on pancreatic β cell function related mechanisms are not fully understood. Thus, present study was performed to investigate potential underlying mechanisms. Both vitro (rat insulinoma cells, INS-1) vivo (high fat diet fed rats) experiments were conducted. The results showed...
Tumor is one of the most serious forms abnormal growth that endangers human health today; its morbidity and mortality are both increasing every year. Most antitumor drugs used currently cannot be absorbed well by body because their poor solubility low bioavailability. Therefore, prevention treatment tumors still high significance. These challenges can addressed use ionic liquids (ILs). Half in market salts linked together ILs. Compared to solid form drug, salt liquid at room temperature or...
Geochemical maps play an important role in mineral resource exploration. There are three traditional methods for creating geochemical maps: the cumulative frequency method, logarithmic interval and Avg±k∗Std (where Avg Std abbreviations of average standard deviation, k is a multiple Std) method. However, with increasing scope study area data, limitations methods, which depend on amount exposed. A fixed-value method Sn geological mapping proposed to overcome methods. In concentrations divided...
Purpose: The purpose of this study was to investigate the involvement TLR4/NF-κB/NLRP3 signaling pathway and its underlying mechanism in diabetic dry eye. Methods: Two models eye were established high glucose-induced human corneal epithelial (HCE-T) cells streptozotocin (STZ)-induced C57BL/6 mice, TLR4 inhibitor fosfenopril (FOS) utilized suppress pathway. expression changes TLR4, NF-κB, NLRP3, IL-1β, other factors detected by Western blot RT‒qPCR, wound healing rate evaluated cell scratch...
Autophagy plays a protective role in endotoxemic mice. Heat shock factor 1 (HSF-1) also crucial mice by decreasing inflammatory cytokines. The purpose of this study was to determine whether HSF-1 is involved attenuating the release cytokines lipopolysaccharide (LPS)-stimulated and peritoneal macrophages (PMs) through regulating autophagy activity. Autophagosome formation HSF-1+/+ HSF-1-/- PMs stimulated LPS examined Western blotting immunofluorescence. Lipopolysaccharide-induced were treated...
Agarwood is the fragrant resinous material mainly formed from species of Aquilaria. 2-(2-phenylethyl)chromones, especially highly oxidized 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones, are main representative compounds agarwood. It important to determine whether agarwood in trade cultivated trees or natural Convention on International Trade Endangered Species (CITES). We characterized 2-(2-phenylethyl)chromones by ultra-performance liquid chromatography coupled with electrospray ionization...
ChCl/citric acid-based DESs are demonstrated to be effective green solvents for the ultrasound-assisted extraction of bioactive alkaloids from herbs.
Abstract Background Retinal degeneration is often accompanied by microglia-mediated neuroinflammation. Ferulic acid (FA), an active ingredient of traditional Chinese medicines (TCMs), has been reported to have anti-inflammatory effects. This study explores the impact FA on neuroinflammation and associated retinal in rd10 mice. Methods Rd10 mice received different concentrations every day from postnatal (P)4 P24. On P25, visual function was evaluated electroretinogram, retinae were collected...