A5084587045- Aluminum Alloy Microstructure Properties
- Aluminum Alloys Composites Properties
- Microstructure and mechanical properties
- Metallurgy and Material Forming
- Microstructure and Mechanical Properties of Steels
- Ion channel regulation and function
- Histone Deacetylase Inhibitors Research
- Hydrogen embrittlement and corrosion behaviors in metals
- Metal and Thin Film Mechanics
- Neuroscience and Neuropharmacology Research
- Advanced Thermoelectric Materials and Devices
- Metal Alloys Wear and Properties
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Cardiac electrophysiology and arrhythmias
- Cellular transport and secretion
- Drilling and Well Engineering
- Industrial Technology and Control Systems
- Advanced Nanomaterials in Catalysis
- Advanced ceramic materials synthesis
- Pharmaceutical and Antibiotic Environmental Impacts
- Lipid metabolism and biosynthesis
- Receptor Mechanisms and Signaling
- Metallurgical Processes and Thermodynamics
- Probabilistic and Robust Engineering Design
Shanghai Jiao Tong University
2025
Central South University
2018-2024
Tianjin University
2019-2023
North China Electric Power University
2022-2023
Hubei University
2023
Yunnan University
2022
Masteel (China)
2019-2022
University of Science and Technology Beijing
2022
Chiba University
2016-2021
Hefei University of Technology
2021
High strength aluminum alloys are widely used but their is reduced as nano-precipitates coarsen rapidly in medium and high temperatures, which greatly limits application. Single solute segregation layers at precipitate/matrix interfaces not satisfactory stabilizing precipitates. Here we obtain multiple interface structures an Al-Cu-Mg-Ag-Si-Sc alloy including Sc layers, C L phases well a newly discovered χ-AgMg phase, partially cover the θ' By atomic resolution characterizations ab initio...
In voltage-dependent potassium channels, the molecular determinants of ion selectivity are found in P (pore) region, a stretch 21 contiguous residues. Cysteine was introduced at each region position Shaker channel. Residues projecting side chains into pore were identified by means channel inhibition sulfhydryl-reactive analog, silver ion. The pattern reactivity contradicts beta barrel architecture pores.
B′ is a common type of metastable precipitate in over-aged Al-Mg-Si alloys, which long regarded as variation the Q Al-Mg-Si-Cu alloys due to similarity between their lattice parameters. Atomic-resolution high angle annular dark field scanning transmission electron microscopy and energy dispersive X-ray elemental mapping at low beam damage conditions, well first-principles calculations were used explore atomistic structure B′. It has hexagonal unit cell with space group P6¯ parameters a=...
Fibroblast growth factor receptors (FGFRs) are established oncogenic drivers in various solid tumors. However, the approved FGFR inhibitors face challenges with acquired resistance and dose-limiting adverse effects associated FGFR1/4 inhibition, limiting therapeutic efficacy. Herein, we systematically explored linker electrophile moieties based on pyrrolopyrazine carboxamide core identified aniline α-fluoroacrylamide as an effective covalent warhead. Compound 10 potently inhibited FGFR2...
Previously, we developed a strategy to develop novel class of histone deacetylase (HDAC) inhibitors by tethering short-chain fatty acids with Zn2+-chelating motifs, which led N-hydroxy-4-(4-phenylbutyryl-amino)benzamide (HTPB), hydroxamate-tethered phenylbutyrate derivative sub-micromolar potency in inhibiting HDAC activity and cancer cell proliferation. In this study, carried out structure-based optimization HTPB using the framework generated structure deacetylase-like protein...
Histone deacetylase (HDAC) inhibitors have shown promise in treating various forms of cancer. However, many HDAC from diverse structural classes been associated with QT prolongation humans. Inhibition the human ether a-go-go related gene (hERG) channel has and fatal arrhythmias. To determine if observed cardiac effects humans is due to hERG blockade, a highly potent inhibitor devoid activity was required. Starting dacinostat (LAQ824), inhibitor, we explored SAR pharmacophores required for...
Significance DHPS is one of the most abundant organosulfonates on this planet. The mechanisms for degradation in anaerobic biosphere are not well understood. Here, we report bioinformatics-aided discovery, biochemical, and structural characterizations two O 2 -sensitive glycyl radical enzymes that use distinct radical-mediated bacteria from diverse terrestrial marine sources as human gut. These play an important role biogeochemical sulfur cycle link dietary sulfonates to microbial production...
Liver fibrosis is a reversible pathological process caused by chronic liver damage and major risk factor for hepatocellular carcinoma (HCC). Hepatic stellate cell (HSC) activation considered the main target therapy. However, efficiency of this strategy limited due to complex microenvironment fibrosis, including excessive extracellular matrix (ECM) deposition hypoxia-induced imbalanced ECM metabolism. Herein, nilotinib (NIL)-loaded hyaluronic acid (HA)-coated Ag@Pt nanotriangular nanozymes...
Among various classes of histone deacetylase (HDAC) inhibitors, short-chain fatty acids exhibit the least potency, with IC(50) in millimolar range. We rationalized that this weak potency was, part, attributable to their inability access zinc cation HDAC active-site pocket, which is pivotal deacetylation catalysis. thus explored structural optimization valproate, butyrate, phenylacetate, and phenylbutyrate by coupling them Zn(2+)-chelating motifs (hydroxamic acid o-phenylenediamine) through...
Rational design and preparation for improving surface chemical properties electron structure of transition metal oxides to enhance their energy storage capacity are highly desired. Herein, a brand-new organic–inorganic hybrid (NH2-MIL-125/ZnMn2O4) consisting metal–organic framework polynary oxide was synthesized successfully further modified by Ag decoration engineering. In detail, the can provide abundant dual reactive sites (Zn Mn), based on decorating, presents an advantageous state,...
The η isozyme of diacylglycerol kinase (DGK) is highly expressed in the hippocampus and Purkinje cells central nervous system. Recently, several genome-wide association studies have implicated DGKη etiology bipolar disorder (BPD). However, it still unknown whether indeed related to BPD. In this study, we generated DGKη-knockout (KO) mice performed behavioral tests such as open field test, elevated plus maze test tail suspension using KO investigate effects deficits on psychomotor behavior....
The effects of Ce content on the microstructure and phase composition Al-5Ti-1B refiner refining effect Al-5Ti-1B-xCe (x = 0, 1, 5, 10 wt.%) grain size, microstructure, mechanical properties Al-5Mg-3Zn-1Cu alloys were studied. results show that addition 1.0 wt.% in changes TiAl3 from block to strip, massive Ti2Al20Ce is formed. When increases 5.0 wt.%, plate-like surrounded by phase, reticulate Al4Ce With further increasing 10.0 a lot network distribution volume Mg32(AlCuZn)49 as-cast...
In this study, we describe the pharmacological characterization of novel aryl-ether, biaryl, and fluorene aspartic acid diaminopropionic analogs as potent inhibitors EAAT2, predominant glutamate transporter in forebrain regions. The rank order potency determined for inhibition human EAAT2 was <i>N</i><sup>4</sup>-[4-(2-bromo-4,5-difluorophenoxy)phenyl]-l-asparagine (WAY-213613) (IC<sub>50</sub> = 85 ± 5 nM) > <i>N</i><sup>4</sup>-(2′-methyl-1,1′-biphenyl-4-yl)-l-asparagine (WAY-213394)...