A5107807701- Lipid metabolism and biosynthesis
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Photosynthetic Processes and Mechanisms
- Receptor Mechanisms and Signaling
- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Traumatic Brain Injury and Neurovascular Disturbances
- Plant biochemistry and biosynthesis
- Neuropeptides and Animal Physiology
- Chemical Synthesis and Analysis
- Neuroscience and Neuropharmacology Research
- Algal biology and biofuel production
- Bone Metabolism and Diseases
- Sleep and Wakefulness Research
- Medical and Biological Ozone Research
- Hormonal Regulation and Hypertension
- Adenosine and Purinergic Signaling
- Sleep and related disorders
- Spine and Intervertebral Disc Pathology
- Anesthesia and Sedative Agents
- Bone health and treatments
- Adipose Tissue and Metabolism
- Nausea and vomiting management
- Microbial Metabolic Engineering and Bioproduction
University of Pittsburgh
2016-2025
Taronga Conservation Society Australia
2025
National Institute on Aging
2010-2024
National Institutes of Health
2015-2024
University of Nottingham
2012-2024
Royal Derby Hospital
2008-2024
Neurocrine Biosciences (United States)
2007-2023
Aviation General Hospital
2013-2023
University of Chinese Academy of Sciences
2022-2023
Pittsburg State University
2018-2022
We investigated how myofibrillar protein synthesis (MPS) and muscle anabolic signalling were affected by resistance exercise at 20-90% of 1 repetition maximum (1 RM) in two groups (25 each) post-absorptive, healthy, young (24 +/- 6 years) old (70 5 men with identical body mass indices 2 kg m(-2)). hypothesized that, response to exercise, molecule phosphorylation MPS would be modified a dose-dependant fashion, but lesser extent older men. Vastus lateralis was sampled before, immediately...
Transgenic Brassica napus plants overexpressing AtNHX1, a vacuolar Na + /H antiport from Arabidopsis thaliana, were able to grow, flower, and produce seeds in the presence of 200 mM sodium chloride. Although transgenic grown high salinity accumulated up 6% their dry weight, growth these was only marginally affected by salt concentration. Moreover, seed yields oil quality not soil. Our results demonstrate potential use for agricultural saline soils. findings, showing that modification single...
Opioids are a group of analgesic agents commonly used in clinical practice. There three classical opioid receptors (DOP, KOP and MOP), while the novel NOP receptor is considered to be non-opioid branch family. can act at these as agonists, antagonists or partial agonists. Opioid agonists bind G-protein coupled cause cellular hyperpolarisation. Most clinically relevant analgesics MOP central peripheral nervous system an agonist manner elicit analgesia. may also classified according their mode...
Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood
The retention of weight gained during pregnancy may contribute to obesity. Lactation should promote loss, but loss is highly variable among lactating women. risks associated with the restriction energy intake lactation have not been adequately evaluated. purpose this study was determine whether by women affects growth their infants.
Light harvesting complex II (LHCII) was purified from cold-hardened (RH) and nonhardened winter rye (RNH) (Secale cereale L. cv Puma) employing a modified procedure of JJ Burke, CL Ditto, CJ Arntzen (Arch Biochem Biophys 187: 252-263). Triton X-100 solubilization thylakoid membranes followed by three successive precipitations with 100 mm KCl 10 MgCl2 resulted in yields up to 25% on chlorophyll (Chl) basis purity 90 95%, based polypeptide analysis within 4 hours. Polypeptide pigment analyses,...
<h3>Background and Objectives</h3> Continuous perineural femoral analgesia has been reported to reduce numeric rating pain scores (NRS, scale 0-10) after anterior cruciate ligament reconstruction (ACLR). In the current study, we determined rebound in autograft ACLR outpatients nerve block resolved. <h3>Methods</h3> After standardized spinal anesthesia perioperative multimodal analgesia, patients received a catheter 50 hours of saline or levobupivacaine. All levobupivacaine (30 mL 0.25% as...
Summary Purpose Posttraumatic epilepsy ( PTE ) occurs in a proportion of traumatic brain injury TBI cases, significantly compounding the disability, and risk death for sufferers. To date, predictive biomarkers have not been identified. This study used lateral fluid percussion LFPI rat model to investigate whether structural, functional, behavioral changes post‐ relate later development . Methods Adult male W istar rats underwent or sham injury. Serial magnetic resonance MR positron emission...
Opioids are a group of analgesic agents commonly used in clinical practice. The three classical opioid receptors MOP, DOP and KOP. NOP (N/OFQ) receptor is considered to be non-opioid branch the family. Opioid G-protein-coupled which cause cellular hyperpolarisation when bound agonists. may classified according their mode synthesis into alkaloids, semi-synthetic synthetic compounds. use disorder (OUD) an emerging issue important lessons can learnt from United States where epidemic was...
While regular physical activity is a cornerstone of health, wellness, and vitality, the impact endurance exercise training on molecular signaling within across tissues remains to be delineated. The Molecular Transducers Physical Activity Consortium (MoTrPAC) was established characterize networks underlying adaptive response exercise. Here, we describe studies undertaken by Preclinical Animal Sites Studies component MoTrPAC, in which sought develop implement standardized protocol large cohort...
Background The performance of anesthetic procedures before operating room entry (e.g., with either general or regional anesthesia [RA] induction rooms) should decrease anesthesia-controlled time in the room. authors retrospectively studied associations between techniques and time, evaluating one surgeon performing a single procedure over 3-yr period. hypothesized that, using care team model, RA would be associated reduced compared (GA) alone combined general-regional (GA-RA). Methods queried...
Anterior cruciate ligament reconstruction is a complex outpatient surgical procedure often associated with pain. Traditionally, the performed under general anesthesia and requires use of PACU. Refractory pain and/or nausea/vomiting occasionally leads to an unplanned hospital admission. In this study, authors examine associations nerve block analgesia for these patients its reductions in PACU use, admission, costs.This was observational, nonrandomized study which existing data regarding...
A simple, versatile, and general approach to the solution phase, parallel synthesis of chemical libraries conducted on a generalized or universal template, which allows preparation multi-milligram quantities each individual member, is described. In step sequence, reactants, unreacted starting material, reagents their byproducts are removed by simple liquid/liquid liquid/solid extractions providing desired intermediates final compounds in high purities (95% average) irrespective reaction...
Background Single-injection femoral nerve block analgesia and spinal anesthesia have been associated with fewer postoperative nursing interventions successful same-day discharge after anterior cruciate ligament reconstruction. In the current study, authors prospectively determined effect of continuous on a numeric rating scale (NRS) pain intensity movement for 7 days. Methods Patients undergoing this surgery no history previous invasive same knee were recruited study. After standardized...
Mood disturbances, including depression and anxiety disorders, are common disabling long-term sequelae of traumatic brain injury (TBI). These psychiatric conditions have generally been considered psychosocial consequences the trauma, but neurobiological alterations causes also implicated. Using a rat model TBI (lateral fluid-percussion injury), this longitudinal study seeks to assess depression-like behaviors following experimental TBI. Male Wistar rats (n = 20) received severe...
Temporal hypometabolism on fluorodeoxyglucose positron emission tomography (FDG-PET) is a common finding in patients with drug-resistant temporal lobe epilepsy (TLE). The pathophysiology underlying the hypometabolism, including whether it reflects primary epileptogenic process, or occurs later as result of limbic atrophy chronic seizures, remains unknown. This study aimed to investigate ontologic relationship among atrophy, histological changes, and rats.Serial vivo imaging FDG-PET...
Aim Performance in the operating room is affected by a combination of individual, patient and environmental factors amongst others. Stress has potential negative impact on performance with quality surgical practice safety being as result. In order to appreciate level stress encountered during procedures both objective subjective methods can be used. This study reports use combined (physiological) (psychological) method for evaluating experienced surgeon. Method Six consultant colorectal...
Abstract A technique is presented for the removal of water and water‐soluble non‐lipid contaminants from lipid extracts. The process quicker simpler than existing techniques recoveries greater 97% have been obtained.
Ambient aerosol fine particulate matter (PM2.5) is associated with male reproductive toxicity in experiments and may have adverse effects the female. However, studies evaluating protective precise mechanisms of aspirin, Vitamin C, E, or ozone against toxic PM2.5are sparse. This study was conducted to investigate possible on fertility female mice treated PM2.5.Eighty-four ICR were divided into six groups: control group, PM2.5group, PM2.5 + aspirin C E group. PM2.5was given by intratracheal...