A5053459416- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Neurobiology of Language and Bilingualism
- Advanced Neuroimaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- Neuroscience and Neuropharmacology Research
- Medical Imaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Lanthanide and Transition Metal Complexes
- Pharmacological Effects and Toxicity Studies
- Pregnancy and preeclampsia studies
- Peripheral Neuropathies and Disorders
- Drug Transport and Resistance Mechanisms
- Glioma Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Autoimmune Neurological Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Memory and Neural Mechanisms
- Face Recognition and Perception
- Neurological disorders and treatments
- Cancer, Hypoxia, and Metabolism
- Memory Processes and Influences
- Spinal Fractures and Fixation Techniques
Washington University in St. Louis
2001-2025
University of California, San Francisco
2008-2009
Neurological Surgery
2000
University of Pennsylvania
1997-1998
To determine the feasibility of using functional magnetic resonance imaging (fMRI) to detect asymmetries in lateralization memory activation patients with temporal lobe epilepsy (TLE).Assessment mesial function is a critical aspect preoperative evaluation for surgery, both predicting postoperative deficits and seizure lateralization. fMRI offers several potential advantages over current gold standard, intracarotid amobarbital testing (IAT). has already been successfully applied language...
Previous studies have demonstrated that cerebral blood flow (CBF) can be assessed noninvasively by MRI using magnetic labeling of arterial water as a diffusible tracer. The purpose this study was to assess the quality CBF images obtained from patients with cerebrovascular disease method, and begin evaluate potential clinical role for technique. We recruited 14 who presented stroke, TIA, or severe carotid stenosis were likely altered based on assessment. In many these patients, imaging...
Summary Purpose Posttraumatic epilepsy ( PTE ) occurs in a proportion of traumatic brain injury TBI cases, significantly compounding the disability, and risk death for sufferers. To date, predictive biomarkers have not been identified. This study used lateral fluid percussion LFPI rat model to investigate whether structural, functional, behavioral changes post‐ relate later development . Methods Adult male W istar rats underwent or sham injury. Serial magnetic resonance MR positron emission...
How epilepsy affects brain functional networks remains poorly understood. Here we investigated resting state connectivity of the temporal region in lobe epilepsy. Thirty-two patients with unilateral underwent blood-oxygenation level dependent magnetic resonance imaging. We defined regions interest a priori focusing on structures involved, either structurally or metabolically, These were identified each patient based their individual anatomy. Our principal findings are decreased local and...
Abstract Stimulus repetition associates with neural activity reductions during tasks that elicit behavioral priming. Here we present direct evidence for a quantitative relation between and Fifty-four subjects performed word classification task while being scanned functional MRI. Activity were found in multiple high-level cortical regions including those within the prefrontal cortex. Importantly, several of these regions, cortex, correlated behavior such greater associated faster performance....
Eighteen participants were imaged using fMRI to explore whether brain regions predicting successful verbal memory encoding during semantic decisions would continue predict structural (non-semantic) decisions. Consistent with prior studies, left inferior frontal and fusiform more active than decisions, activity was greater for remembered forgotten words Critically, yielded significantly in these providing evidence that a common frontal-temporal network supports irrespective of orienting task....
Velocity-driven adiabatic inversion is an attractive method for labeling arterial blood spins quantitative perfusion imaging. To quantify and to optimize experimental parameters, accurate estimate of efficiency required. We present theoretical numerical methods calculate the over a wide range physiologic parameters. The results are compared measurements in vivo. Inversion was found be higher than previously assumed relatively insensitive flow velocity amplitude RF irradiation used inversion....
Abstract Objective Localization of focal epilepsy is critical for surgical treatment refractory seizures. There remains a great need noninvasive techniques to localize seizures decision‐making. We investigate the use deep learning using resting state functional magnetic resonance imaging (RS‐fMRI) identify hemisphere seizure onset in temporal lobe (TLE) patients. Methods A total 2132 healthy controls and 32 preoperative TLE patients were studied. All participants underwent structural MRI...
BACKGROUND Despite rapid adoption among many epilepsy centers across the United States, stereotactic magnetic resonance imaging (MRI) thermometry–guided laser interstitial thermal therapy (LITT) is not universally available to treat medically refractory in appropriately selected patients. OBSERVATIONS The authors present two cases which patients with mesial temporal lobe (MTLE)—one stereoelectroencephalography-proven left MTLE and one right sclerosis—were advised undergo LITT by a...
Summary Objective Hippocampal atrophy in temporal lobe epilepsy ( TLE ) can indicate mesial sclerosis and predict surgical success. Yet many patients with do not have significant (magnetic resonance imaging MRI negative), which presents a diagnostic challenge. We used new variant of high‐dimensional large‐deformation mapping to assess whether apparently normal hippocampi local shape changes that mirror those hippocampal atrophy. Methods Forty‐seven unilateral 32 controls underwent structural...
Frontal recruitment was characterized using functional magnetic resonance imaging (fMRI) during memory encoding in temporal lobe epilepsy (TLE) patients before and after unilateral medial lobectomy. Twenty-four TLE 12 healthy controls underwent a preoperative fMRI session consisting of verbal nonverbal incidental memory-encoding tasks that typically lead to robust, lateralized frontal activity controls. A similar postoperative performed subset patients. Preoperatively, the task resulted...
Specific changes in the functional connectivity of brain networks occur patients with epilepsy. Yet whether such reflect a stable disease effect or one that is function active seizure burden remains unclear. Here, we longitudinally assessed canonical cognitive intractable temporal lobe epilepsy (TLE), both before and after underwent surgery achieved freedom.Seventeen TLE who Engel class I outcome 17 matched healthy controls took part study. The set derived from typical tasks was patients,...
Preclinical and clinical studies have demonstrated the significance of inflammation autoantibodies in epilepsy, use immunotherapies certain situations has become an established practice. Temporal lobe epilepsy can follow paraneoplastic or nonparaneoplastic limbic encephalitis associated with antibodies directed against brain antigens. Here, we focus on a patient worsening confusion temporal seizures despite treatment antiepileptic medications. Serial MRIs did not conclusively reveal...
ABSTRACT BACKGROUND AND PURPOSE To demonstrate the accuracy across different acquisition and analysis methods, we evaluated variability in hippocampal volumetric surface displacement measurements resulting from two MRI (magnetic resonance imaging) protocols. METHODS Nine epilepsy patients underwent independent T1‐weighted magnetization prepared spoiled gradient sequences during a single 3T session. Using high‐dimension mapping‐large deformation (HDM‐LD) segmentation, calculated estimates...
Objective: We undertook the design and implementation of a proactive telecommunication tool, EpxEpilepsy, to more accurately frequently track seizures, thereby improving care epilepsy patients. Additionally, we present cost-benefit analysis that demonstrates its capability enable new revenue generation for providers under recent fee-for-service codes. Background: To fill in gaps between often long periods clinic visits, management revolves around self-recorded seizure diaries, which can be...