A5101873972- Biomarkers in Disease Mechanisms
- Mesenchymal stem cell research
- Air Quality and Health Impacts
- Helicobacter pylori-related gastroenterology studies
- Galectins and Cancer Biology
- Angiogenesis and VEGF in Cancer
- Eosinophilic Esophagitis
- Cardiovascular Health and Disease Prevention
- Climate Change and Health Impacts
- Inflammasome and immune disorders
- Pharmacological Effects of Natural Compounds
- Immune cells in cancer
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cholesterol and Lipid Metabolism
- Nitric Oxide and Endothelin Effects
- Pediatric health and respiratory diseases
- Reproductive Biology and Fertility
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Disease and Adiposity
- Vitamin C and Antioxidants Research
- Immune Response and Inflammation
- Zebrafish Biomedical Research Applications
- Antioxidant Activity and Oxidative Stress
Soochow University
2024-2025
University of Missouri
2018-2024
First Affiliated Hospital of Soochow University
2024
University of Missouri Hospital
2020
The Ohio State University Wexner Medical Center
2006-2015
Lung Institute
2015
The Ohio State University
2006-2015
Kindai University
2008-2009
University of Southern California
2005-2007
Zhengzhou People's Hospital
2006
Background/Aims: Bone marrow (BM)-derived endothelial progenitor cells (EPCs) play a critical role in angiogenesis and vascular repair. Some environmental insults, like fine particulate matter (PM) exposure, significantly impair cardiovascular functions. However, the mechanisms for PM-induced adverse effects on system remain largely unknown. The present research was to study detrimental of PM EPCs explore potential mechanisms. Methods: intranasal-distilled into male C57BL/6 mice one month....
Background Epidemiological studies have suggested an association between Helicobacter pylori ( H ) infection and atherosclerosis through undefined mechanisms. Endothelial dysfunction is critical to the development of related cardiovascular diseases. The present study was designed test hypothesis that impaires endothelial function exosome‐mediated Methods Results Young male female patients (18‐35 years old) with without were recruited minimize chance potential risk factors for study....
Helicobacter pylori (H. pylori) infection increases the risk for atherosclerosis, and ROS are critical to endothelial dysfunction atherosclerosis. CagA is a major H. virulence factor associated with The present study aimed test hypothesis that CagA+H. effectively colonizes gastric mucosa, pylori, but not CagA-H. impairs function through exosomes-mediated formation.C57BL/6 were used determine colonization ability of pylori. production, thoracic aorta atherosclerosis measured in infected mice....
Atherosclerosis remains a leading cause of cardiovascular diseases. Although the mechanism for atherosclerosis is complex and has not been fully understood, inflammation oxidative stress play critical role in development progression atherosclerosis. N-acetylcysteine (NAC) used as mucolytic agent an antidote acetaminophen overdose with well-established safety profile. NAC antioxidant anti-inflammatory effects through multiple mechanisms, including increase intracellular glutathione level...
Acupoint Zusanli (ST36) has been shown to reduce blood pressure, but the underlying mechanism remains unknown. This study aimed characterize effects of manual acupuncture (MA) at ST36 on BP and its associated mechanisms in anesthetized rats. The cardiovascular response MA Sprague-Dawley rats was measured by electrocardiogram, hemodynamic methods, heart rate variability, echocardiography, laser speckle contrast imaging, Western blotting. RNA sequencing employed for mechanistic investigation,...
Abstract Cell therapy with bone marrow stem cells ( BMSC s) remains a viable option for tissue repair and regeneration. A major challenge cell is the limited survival after implantation. This study was to investigate effect of oxidized low‐density lipoprotein (ox‐ LDL , naturally present in human blood) on injury MG 53, protein, improvement survival. Rat multipotent adult progenitor MAPC were treated ox‐ which caused significant death as reflected by increased LDH release media. Exposure s...
Aims Some environmental insults, such as fine particulate matter (PM) exposure, significantly impair the function of stem cells. However, it is unknown if PM exposure could affect population bone marrow cells (BMSCs). The present study was to investigate effects on BMSCs and related mechanism(s). Main Metheods intranasally distilled into male C57BL/6 mice for one month. Flow cytometry with antibodies BMSCs, Annexin V BrdU ware used determine number levels their apoptosis proliferation in...
Background and Purpose: Early neurological deterioration (END) is associated with poor outcome for patients acute ischemic stroke (AIS). Patients hyperglycemia have increased risk stroke, tend to without diabetes after stroke. The present study aimed determine if blood glucose was END sex difference in development of AIS patients. Methods: 220 consecutive recanalization treatment between 2012 2015 were screened this retrospective study. After exclusion, 213 included analysis. Propensity...
Abstract Low-density lipoprotein (LDL) is non-atherogenic, while oxidized LDL (ox-LDL) critical to atherosclerosis. N-acetylcysteine (NAC) has anti-atherosclerotic effect with largely unknown mechanisms. The present study aimed determine if NAC could attenuate in vivo oxidation and inhibit A single dose of human native was injected intravenously into male C57BL/6 mice without treatment. Serum ox-LDL detected 30 min after injection, reached the peak 3 hours became undetectable 12 hours....
Formononetin (FMNT) is a major bioactive compound from Astragalus membranaceus (Fisch.) Bunge, and has been widely used to treat conditions related vascular insufficiency. However, the molecular mechanism for therapeutic effect not well defined. This study aimed investigate of FMNT on endothelial function. The potential targets signaling pathways in setting ischemia were predicted using network pharmacology analysis. Human umbilical vein cells (HUVECs) vitro studies C57BL/6 mice vivo...
Critical limb ischemia (CLI) is a severe complication of diabetes mellitus that occurs without effective therapy. Excessive reactive oxygen species (ROS) production and oxidative stress play critical roles in the development diabetic cardiovascular complications. N-acetylcysteine (NAC) reduces ischemia-induced ROS production. The present study aimed to investigate effect NAC on recovery ischemic an experimental model type-2 diabetes. TALLYHO/JngJ SWR/J non-diabetic mice were used for...
Background Substantial sex differences exist in atherosclerosis. Excessive reactive oxygen species (ROS) formation could lead to endothelial dysfunction which is critical atherosclerosis development and progression. Helicobacter pylori (H. pylori) infection has been shown attenuate function via exosomes-mediated ROS formation. We have demonstrated that H. selectively increases risk males with unknown mechanism(s). The present study was test the hypothesis impaired male mice through...
Background Therapy with mesenchymal stem cells remains a promising but challenging approach to critical limb ischemia in diabetes because of the dismal cell survival. Methods and Results Critical type 2 mouse model was used explore impact diabetic on survival bone marrow stromal (bMSCs). Inhibition intracellular reactive oxygen species achieved concomitant overexpression superoxide dismutase (SOD)-1 glutathione peroxidase-1 transplanted bMSCs, extracellular attenuated using SOD-3...
Males have a higher risk for cardiovascular diseases (CVDs) than females. Ambient fine particulate matter (PM) exposure increases CVD with increased reactive oxygen species (ROS) production and oxidative stress. Endothelial progenitor cells (EPCs) are important to vascular structure function can contribute the development of CVDs. The aims present study were determine if sex differences exist in effect PM on circulating EPCs mice and, so, whether stress plays role. Male female C57BL/6 (8–10...