A5101715870- Circular RNAs in diseases
- Natural product bioactivities and synthesis
- MicroRNA in disease regulation
- Ginseng Biological Effects and Applications
- Ophthalmology and Eye Disorders
- Connexins and lens biology
- Air Quality and Health Impacts
- Neurological disorders and treatments
- Biomarkers in Disease Mechanisms
- Cardiac Ischemia and Reperfusion
- Phytochemistry and Biological Activities
- Genetic Neurodegenerative Diseases
- Cancer-related molecular mechanisms research
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Advanced Glycation End Products research
- Neonatal Respiratory Health Research
- Multiple Sclerosis Research Studies
- Retinal Diseases and Treatments
- Peripheral Neuropathies and Disorders
- Ubiquitin and proteasome pathways
- Sphingolipid Metabolism and Signaling
- Pediatric health and respiratory diseases
- Clusterin in disease pathology
- Kawasaki Disease and Coronary Complications
Affiliated Hospital of Guangdong Medical College Hospital
2022-2025
Guangdong Medical College
2022-2025
City University of Hong Kong, Shenzhen Research Institute
2025
University of Hong Kong
2025
Guangxi Medical University
2008-2021
First Affiliated Hospital of GuangXi Medical University
2008-2021
First Affiliated Hospital Zhejiang University
2020
Children's Hospital of Chongqing Medical University
2010-2020
Chongqing Medical University
2010-2020
Chinese PLA General Hospital
2020
Abstract The hearts of subjects with diabetes are vulnerable to ischemia–reperfusion injury (IRI). In contrast, experimentally rodent have been shown be more resistant IRI at the very early stages induction than heart non-diabetic control mice, and mechanism is largely unclear. Ferroptosis has recently play an important role in myocardial including that diabetes, while specific mechanisms still Non-diabetic (NC) streptozotocin-induced diabetic (DM) mice were treated antioxidant...
Background/Aims: Bone marrow (BM)-derived endothelial progenitor cells (EPCs) play a critical role in angiogenesis and vascular repair. Some environmental insults, like fine particulate matter (PM) exposure, significantly impair cardiovascular functions. However, the mechanisms for PM-induced adverse effects on system remain largely unknown. The present research was to study detrimental of PM EPCs explore potential mechanisms. Methods: intranasal-distilled into male C57BL/6 mice one month....
Graves' ophthalmopathy is an inflammatory autoimmune disease of the orbit, characterized by inflammation and proliferation orbital tissue caused CD4+T cells fibroblasts. Despite recent substantial findings regarding its cellular molecular foundations, pathogenesis remains unclear. Accumulating data suggest that microRNAs play important roles in pathophysiology autoimmunity proliferation. Specifically, microRNA-155 (miR-155) can promote enhancing T cell development. In contrast to miR-155,...
Pancreatic cancer has the poorest prognosis among all types, due to its late diagnosis and lack of effective therapies. Therefore, identification novel gene targets, which are differentially expressed in pancreatic functionally involved malignant phenotype, is critical achieve early develop therapeutic strategies. microRNAs (miRNAs) small non-coding RNAs, negatively regulate expression their targets. Due various miRNAs play a key role number physiological processes oncogenesis. investigating...
As a de-ubiquitin enzyme, ubiquitin C-terminal hydrolase (UCH)-L1 has been shown to be overexpressed in several human cancers. However, the function of UCH-L1 invasion breast cancers is still unclear. Here we report that expression significantly higher cancer cells with invasive ability. While ectopic failed alter cell proliferation MCF-7 cells, it caused significant upregulation cellular invasion. Furthermore, siRNA mediated knockdown led suppression overexpressing cells. In order identify...
ABSTRACT Myocardial ischemia–reperfusion injury (MIRI) significantly affects the prognosis of cardiac surgery patients. The anesthetic dexmedetomidine (Dex) has shown protective effects against in cardiomyocytes; however, its exact mechanism remains unclear. In this study, hypoxia/reoxygenation (H/R) and ischemia/reperfusion (I/R) models were used to investigate Dex on H9c2 cells MIRI mice. roles Sirtuin 1/Forkhead box O3a (Sirt1/FoxO3a) pathway explored using Sirt1 inhibitor EX527 FoxO3a...
Aims Some environmental insults, such as fine particulate matter (PM) exposure, significantly impair the function of stem cells. However, it is unknown if PM exposure could affect population bone marrow cells (BMSCs). The present study was to investigate effects on BMSCs and related mechanism(s). Main Metheods intranasally distilled into male C57BL/6 mice for one month. Flow cytometry with antibodies BMSCs, Annexin V BrdU ware used determine number levels their apoptosis proliferation in...
Background The thalamus is a key node of deep gray matter and previous studies have demonstrated that it involved in the modulation cognition. Purpose To investigate volume changes its subregions altered functional connectivity patterns Parkinson's disease (PD) patients with without mild cognitive impairment (MCI). Study Type Prospective. Population Thirty‐three MCI ( PD‐MCI ), 36 PD having no PD‐NCI 21 healthy controls HCs ). Sequence 3.0T MRI scanner; 3D T 1 ‐weighted fast spoiled gradient...
This study focused on the mechanism underlying therapeutic effect of curcumin against tongue cancer (TC).Target genes TC and were identified, respectively. Three datasets from Gene Expression Omnibus included, then differentially expressed collected. After combing data The Cancer Genome Atlas, bioinformatics analyses performed to investigate hub in terms functions correlations. proliferation migration cells evaluated with CCK-8 assay scratch wound healing assay, Cell apoptosis was by TUNEL...
Abstract Our previous study demonstrated that gypenosides (Gp) exert protective effects on retinal nerve fibers and axons in a mouse model of experimental autoimmune optic neuritis. However, the therapeutic mechanisms remain unclear. Thus, this study, oxidative damage ganglion cells (RGCs) was established to investigate effect Gp, its possible influence stress RGCs. Treatment with H 2 O induced RGC injury owing generation intracellular reactive oxygen species (ROS). In addition, activities...
To determine whether gypenosides have protective effects in experimental autoimmune optic neuritis (EAON).Mice were randomly divided into seven groups: control group, model three different density monotherapy, methylprednisolone combination of and group. The group was subcutaneously injected with oil emulsion adjuvant all other groups immunized an emulsified mixture myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide to induce EAON. Mice the administered injections daily concentrations...
Quantitative measurement of the orbital soft tissue volume plays a very important role in study diseases. The purpose this is to establish computed tomography- (CT-) based three-dimensional (3D) reconstruction model and measure Chinese adults. We collected data from 103 adults (52 males 51 females) who underwent CT. CT images these were used reconstruct 3D bony cavity, fat, extraocular muscle, intraorbital optic nerve using Mimics software, their respective volumes measured. mean (±SD)...
Thyroid-associated ophthalmopathy is the commonest orbital disease in adults. However, shortcomings still exist treatments. The aim of this study was to identify efficacy and potential mechanism gypenosides treatment thyroid-associated ophthalmopathy. Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform screened for active compounds gypenosides, targets were predicted using Swiss Target Prediction. obtained from Online Mendelian Inheritance Man, Comparative...
BACKGROUND Primary RPE cells could be a reliable model for representing in vivo status of compared with cell lines. We present protocol vitro isolation and culture primary from C57BL mice. MATERIAL AND METHODS used mice ages 7 days to 4 months. The layer was separated the neural retina by digestion 2% Dispase 45 min scraped off choroid after 25-min incubation 37°C. Collected sheets were gently pipetted up into smaller sheets. transferred well plates cultured 2 weeks. To inhibit...
To investigate the positive rate and types of cells that express Epstein-Barr virus-encoded small RNAs (EBERs) to determine distribution EBER-expressing in idiopathic orbital inflammatory pseudotumor (IOIP) tissues.We retrospectively examined 40 archived paraffin specimens from two teaching hospitals Southern China between January 2007 2015 were pathologically determined exhibit IOIP. Eleven concurrent thyroid-associated ophthalmopathy (TAO) composed control group. In situ hybridization was...